quinModel                package:nlme                R Documentation

Model function for the Quinidine data

Description:

     A model function for a model used with the 'Quinidine' data. This
     function calls compiled C code.

Usage:

     quinModel(Subject, time, conc, dose, interval, lV, lKa, lCl)

Arguments:

 Subject: a factor identifying the patient on whom the data were
          collected. 

    time: a numeric vector giving the time (hr) at which the drug was
          administered or the blood sample drawn.  This is measured
          from the time the patient entered the study. 

    conc: a numeric vector giving the serum quinidine concentration
          (mg/L). 

    dose: a numeric vector giving the dose of drug administered (mg).
          Although there were two different forms of quinidine
          administered, the doses were adjusted for differences in salt
          content by conversion to milligrams of quinidine base. 

interval: a numeric vector giving the when the drug has been given at
          regular intervals for a sufficiently long period of time to
          assume steady state behavior, the interval is recorded. 

      lV: numeric.  A vector of values of the natural log of the
          effective volume of distribution according to 'Subject' and
          'time'.

     lKa: numeric.  A vector of values of the natural log of the
          absorption rate constant according to 'Subject' and 'time'.

     lCl: numeric.  A vector of values of the natural log of the
          clearance parameter according to 'Subject' and 'time'.

Details:

     See the details section of 'Quinidine' for a description of the
     model function that 'quinModel' evaluates.

Value:

     a numeric vector of predicted quinidine concentrations.

Author(s):

     Jose Pinheiro jose.pinheiro@pharma.novartis.com and Douglas Bates
     bates@stat.wisc.edu

References:

     Pinheiro, J. C. and Bates, D. M. (2000) _Mixed-effects Models in S
     and S-PLUS_, Springer. (section 8.2)

