R: Model function for the Phenobarb data

phenoModel {nlme} | R Documentation

## Model function for the Phenobarb data

### Description

A model function for a model used with the `Phenobarb` data. This function uses compiled C code to improve execution speed.

### Usage

    phenoModel(Subject, time, dose, lCl, lV)

### Arguments

`Subject` | an integer vector of subject identifiers. These should be sorted in increasing order.
`time` | numeric. A vector of the times at which the sample was drawn or the drug administered (hr).
`dose` | numeric. A vector of doses of drug administered (μg/kg).
`lCl` | numeric. A vector of values of the natural log of the clearance parameter according to `Subject` and `time`.
`lV` | numeric. A vector of values of the natural log of the effective volume of distribution according to `Subject` and `time`.

### Details

See the details section of `Phenobarb` for a description of the model function that `phenoModel` evaluates.

### Value

a numeric vector of predicted phenobarbital concentrations.

### Author(s)

Jose Pinheiro jose.pinheiro@pharma.novartis.com and Douglas Bates bates@stat.wisc.edu

### References

Pinheiro, J. C. and Bates, D. M. (2000) Mixed-effects Models in S and S-PLUS, Springer. (section 6.4)

[Package nlme version 3.1-89 Index]