go.id go.term Definition Ontology pvalue count.InDataset count.InGenome totaltermInDataset totaltermInGenome BH.adjusted.p.value GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. BP 2.48809271916868e-07 6 185 1874 1389949 0.00020178431952458 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. BP 1.82455353040021e-06 5 144 1874 1389949 0.000739856456577285 GO:0031497 chromatin assembly The assembly of DNA, histone proteins, other associated proteins, and sometimes RNA, into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus. BP 3.05679846359056e-06 5 160 1874 1389949 0.00074052651158065 GO:0034728 nucleosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes. BP 4.10859657470555e-06 5 170 1874 1389949 0.00074052651158065 GO:0045815 positive regulation of gene expression, epigenetic Any epigenetic process that activates or increases the rate of gene expression. BP 4.56551486794482e-06 4 79 1874 1389949 0.00074052651158065 GO:0006323 DNA packaging Any process in which DNA and associated proteins are formed into a compact, orderly structure. BP 8.60780094093925e-06 5 198 1874 1389949 0.00116348776051696 GO:0006335 DNA replication-dependent nucleosome assembly The formation of nucleosomes on newly replicated DNA, coupled to strand elongation. BP 1.17866297307787e-05 3 32 1874 1389949 0.00119486958895769 GO:0034723 DNA replication-dependent nucleosome organization The formation or destruction of chromatin structures on newly replicated DNA, coupled to strand elongation. BP 1.17866297307787e-05 3 32 1874 1389949 0.00119486958895769 GO:0065004 protein-DNA complex assembly The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex. BP 1.62675482684402e-05 5 226 1874 1389949 0.00146588684952278 GO:0000183 chromatin silencing at rDNA Repression of transcription of ribosomal DNA by altering the structure of chromatin. BP 2.15646553728481e-05 3 39 1874 1389949 0.00174889355073798 GO:0051290 protein heterotetramerization The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical. BP 2.70067908957716e-05 3 42 1874 1389949 0.00184954872220665 GO:0071824 protein-DNA complex subunit organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. BP 2.7366935470382e-05 5 252 1874 1389949 0.00184954872220665 GO:0071103 DNA conformation change A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule. BP 4.36037969870193e-05 5 278 1874 1389949 0.00272020610434405 GO:0006325 chromatin organization Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin. BP 8.17404668383365e-05 7 743 1874 1389949 0.00473510847184935 GO:0006303 double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear. BP 0.000105081121450222 3 66 1874 1389949 0.00568138596640867 GO:0000726 non-recombinational repair A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA. BP 0.00014182215287489 3 73 1874 1389949 0.00718861037384599 GO:0045653 negative regulation of megakaryocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation. BP 0.000274008940206789 2 18 1874 1389949 0.0130718382651592 GO:0034622 cellular macromolecular complex assembly The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level. BP 0.000387166330146696 7 961 1874 1389949 0.017443994097165 GO:0040029 regulation of gene expression, epigenetic Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. BP 0.000439570834719387 4 256 1874 1389949 0.0187627340503907 GO:0006342 chromatin silencing Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin. BP 0.000539758938108834 3 115 1874 1389949 0.0218872249403132 GO:0051291 protein heterooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. BP 0.000567531189630165 3 117 1874 1389949 0.0219175140376221 GO:0045652 regulation of megakaryocyte differentiation Any process that modulates the frequency, rate or extent of megakaryocyte differentiation. BP 0.000719976197227444 2 29 1874 1389949 0.0265409407250662 GO:0045814 negative regulation of gene expression, epigenetic Any epigenetic process that stops, prevents or reduces the rate of gene expression. BP 0.000787700493551251 3 131 1874 1389949 0.027775004359568 GO:0051262 protein tetramerization The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. BP 0.000859226545386168 3 135 1874 1389949 0.0290346970128409 GO:0032200 telomere organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins. BP 0.00105569367973976 3 145 1874 1389949 0.0331905349868832 GO:0060412 ventricular septum morphogenesis The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. BP 0.00117261668022699 2 37 1874 1389949 0.0331905349868832 GO:0031047 gene silencing by RNA Any process in which RNA molecules inactivate expression of target genes. BP 0.00132622139058814 3 157 1874 1389949 0.0331905349868832 GO:0006338 chromatin remodeling Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. BP 0.00135053964804827 3 158 1874 1389949 0.0331905349868832 GO:0034080 CENP-A containing nucleosome assembly The formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres. BP 0.00150918506893137 2 42 1874 1389949 0.0349699740258097 GO:0061641 CENP-A containing chromatin organization Any process that results in the specification, formation or maintenance of the physical structure of CENP-A containing chromatin. BP 0.00150918506893137 2 42 1874 1389949 0.0349699740258097 GO:1904837 beta-catenin-TCF complex assembly The aggregation, arrangement and bonding together of a set of components to form a beta-catenin-TCF complex. BP 0.00165521264835066 2 44 1874 1389949 0.0363582506131747 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. BP 0.00165876112538528 5 618 1874 1389949 0.0363582506131747 GO:0031055 chromatin remodeling at centromere Dynamic structural changes in centromeric DNA. BP 0.00180770057884564 2 46 1874 1389949 0.0385801360379951 GO:0016233 telomere capping A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins. BP 0.00204846727291062 2 49 1874 1389949 0.0415326739582628 GO:0030219 megakaryocyte differentiation The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. BP 0.00204846727291062 2 49 1874 1389949 0.0415326739582628 GO:0006336 DNA replication-independent nucleosome assembly The formation of nucleosomes outside the context of DNA replication. BP 0.00239176747754227 2 53 1874 1389949 0.0445997864663038 GO:0034724 DNA replication-independent nucleosome organization The formation or destruction of chromatin structures, occurring outside the context of DNA replication. BP 0.00239176747754227 2 53 1874 1389949 0.0445997864663038 GO:0034508 centromere complex assembly The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere. BP 0.00248154120031065 2 54 1874 1389949 0.0445997864663038 GO:0043486 histone exchange The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits. BP 0.0025728855725019 2 55 1874 1389949 0.0445997864663038 GO:0006302 double-strand break repair The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. BP 0.0026003959196695 3 199 1874 1389949 0.0445997864663038 GO:0006461 protein complex assembly The aggregation, arrangement and bonding together of a set of components to form a protein complex. BP 0.00311836816433613 7 1387 1874 1389949 0.0495881682603255 GO:0070271 protein complex biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a protein complex. Includes the synthesis of non-protein components, and those protein modifications that are involved in synthesis or assembly of the complex. BP 0.00311836816433613 7 1387 1874 1389949 0.0495881682603255 GO:0003281 ventricular septum development The progression of the ventricular septum over time from its formation to the mature structure. BP 0.00335965854972173 2 63 1874 1389949 0.0514091147891382 GO:0060411 cardiac septum morphogenesis The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart. BP 0.00335965854972173 2 63 1874 1389949 0.0514091147891382 GO:0016458 gene silencing Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression. BP 0.00480803664758361 3 248 1874 1389949 0.0644310901410925 GO:0043044 ATP-dependent chromatin remodeling Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. BP 0.00484623489347305 2 76 1874 1389949 0.0644310901410925 GO:0043933 macromolecular complex subunit organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a macromolecular complex. BP 0.00573077071404793 9 2380 1874 1389949 0.0726196101420761 GO:0045638 negative regulation of myeloid cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. BP 0.00602209498516246 2 85 1874 1389949 0.0751372158917962 GO:0071822 protein complex subunit organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex. BP 0.00701728973091357 7 1616 1874 1389949 0.0790419718301515 GO:0003279 cardiac septum development The progression of a cardiac septum over time, from its initial formation to the mature structure. BP 0.00761720252662253 2 96 1874 1389949 0.0846239897135736 GO:0065003 macromolecular complex assembly The aggregation, arrangement and bonding together of a set of macromolecules to form a complex. BP 0.00778885393269428 7 1649 1874 1389949 0.0853616289110143 GO:0034968 histone lysine methylation The modification of a histone by addition of one or more methyl groups to a lysine residue. BP 0.0085586838755053 2 102 1874 1389949 0.0913301660925631 GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. CC 1.14516668780501e-06 5 102 691 396679 0.00014130636276277 GO:0044815 DNA packaging complex A protein complex that plays a role in the process of DNA packaging. CC 1.51942325551366e-06 5 108 691 396679 0.00014130636276277 GO:0032993 protein-DNA complex A macromolecular complex containing both protein and DNA molecules. CC 1.51271413028553e-05 5 173 691 396679 0.000937882760777029 GO:0000785 chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. CC 0.000158663350842121 6 450 691 396679 0.00737784581415863 GO:0035327 transcriptionally active chromatin The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed. CC 0.000622473607884022 2 21 691 396679 0.0231560182132856 GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. CC 0.00119732279749841 7 906 691 396679 0.0371170067224507 GO:0000784 nuclear chromosome, telomeric region The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins. CC 0.00166857837167272 3 132 691 396679 0.0443365110187323 GO:0044454 nuclear chromosome part Any constituent part of a nuclear chromosome, a chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. CC 0.00192275246875122 5 496 691 396679 0.0447039948984659 GO:0000788 nuclear nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures. CC 0.00249104712808846 2 42 691 396679 0.0470016114651254 GO:0000228 nuclear chromosome A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. CC 0.00255635911843172 5 530 691 396679 0.0470016114651254 GO:0044427 chromosomal part Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. CC 0.00302050462589907 6 798 691 396679 0.0470016114651254 GO:0000781 chromosome, telomeric region The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins. CC 0.00303236203000809 3 163 691 396679 0.0470016114651254 GO:0070062 extracellular exosome A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. CC 0.0103261343560591 11 2765 691 396679 0.0830334389090192 GO:1903561 extracellular vesicle Any vesicle that is part of the extracellular region. CC 0.0106877927682959 11 2779 691 396679 0.0830334389090192 GO:0043230 extracellular organelle Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi. CC 0.0107139921172928 11 2780 691 396679 0.0830334389090192 GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues. CC 0.0138497701115738 4 523 691 396679 0.0920112362511551