go.id go.term Definition Ontology pvalue count.InDataset count.InGenome totaltermInDataset totaltermInGenome BH.adjusted.p.value GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. BP 8.98843690727653e-07 5 144 1620 1389949 0.00043756024269882 GO:0031497 chromatin assembly The assembly of DNA, histone proteins, other associated proteins, and sometimes RNA, into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus. BP 1.50953871254892e-06 5 160 1620 1389949 0.00043756024269882 GO:0034728 nucleosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes. BP 2.03201351098523e-06 5 170 1620 1389949 0.00043756024269882 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. BP 3.07161590992323e-06 5 185 1620 1389949 0.000496065969452602 GO:0006323 DNA packaging Any process in which DNA and associated proteins are formed into a compact, orderly structure. BP 4.27522431003909e-06 5 198 1620 1389949 0.00055235898085705 GO:0006335 DNA replication-dependent nucleosome assembly The formation of nucleosomes on newly replicated DNA, coupled to strand elongation. BP 7.64260750738135e-06 3 32 1620 1389949 0.000655181550480789 GO:0034723 DNA replication-dependent nucleosome organization The formation or destruction of chromatin structures on newly replicated DNA, coupled to strand elongation. BP 7.64260750738135e-06 3 32 1620 1389949 0.000655181550480789 GO:0065004 protein-DNA complex assembly The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex. BP 8.1137034115268e-06 5 226 1620 1389949 0.000655181550480789 GO:0071824 protein-DNA complex subunit organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. BP 1.37031319212563e-05 5 252 1620 1389949 0.000904153833170171 GO:0000183 chromatin silencing at rDNA Repression of transcription of ribosomal DNA by altering the structure of chromatin. BP 1.39961893679593e-05 3 39 1620 1389949 0.000904153833170171 GO:0051290 protein heterotetramerization The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical. BP 1.75355007861268e-05 3 42 1620 1389949 0.00102981213707617 GO:0071103 DNA conformation change A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule. BP 2.19185470355474e-05 5 278 1620 1389949 0.00117994844874697 GO:0045815 positive regulation of gene expression, epigenetic Any epigenetic process that activates or increases the rate of gene expression. BP 0.000116965380715862 3 79 1620 1389949 0.00581227968788053 GO:0045653 negative regulation of megakaryocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation. BP 0.000205146992018169 2 18 1620 1389949 0.00946606834598123 GO:0006325 chromatin organization Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin. BP 0.00027455603523575 6 743 1620 1389949 0.0118242132508196 GO:0006342 chromatin silencing Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin. BP 0.000353958978926556 3 115 1620 1389949 0.0141463328143468 GO:0051291 protein heterooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. BP 0.000372271916167022 3 117 1620 1389949 0.0141463328143468 GO:0045814 negative regulation of gene expression, epigenetic Any epigenetic process that stops, prevents or reduces the rate of gene expression. BP 0.000517669933484762 3 131 1620 1389949 0.018248887997164 GO:0045652 regulation of megakaryocyte differentiation Any process that modulates the frequency, rate or extent of megakaryocyte differentiation. BP 0.000539757245088099 2 29 1620 1389949 0.018248887997164 GO:0051262 protein tetramerization The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. BP 0.000564981052543778 3 135 1620 1389949 0.018248887997164 GO:0032200 telomere organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins. BP 0.000695103553114893 3 145 1620 1389949 0.0213827093005819 GO:0031047 gene silencing by RNA Any process in which RNA molecules inactivate expression of target genes. BP 0.000874639434059392 3 157 1620 1389949 0.0246292285604168 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. BP 0.00087689203852877 5 618 1620 1389949 0.0246292285604168 GO:0034080 CENP-A containing nucleosome assembly The formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres. BP 0.00113319973612205 2 42 1620 1389949 0.0292818811813938 GO:0061641 CENP-A containing chromatin organization Any process that results in the specification, formation or maintenance of the physical structure of CENP-A containing chromatin. BP 0.00113319973612205 2 42 1620 1389949 0.0292818811813938 GO:1904837 beta-catenin-TCF complex assembly The aggregation, arrangement and bonding together of a set of components to form a beta-catenin-TCF complex. BP 0.0012431478019719 2 44 1620 1389949 0.0308874415413018 GO:0031055 chromatin remodeling at centromere Dynamic structural changes in centromeric DNA. BP 0.00135800205664941 2 46 1620 1389949 0.0324914566146488 GO:0016233 telomere capping A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins. BP 0.00153943131708704 2 49 1620 1389949 0.0342921596840768 GO:0030219 megakaryocyte differentiation The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. BP 0.00153943131708704 2 49 1620 1389949 0.0342921596840768 GO:0006336 DNA replication-independent nucleosome assembly The formation of nucleosomes outside the context of DNA replication. BP 0.00179829069004794 2 53 1620 1389949 0.0374740576055151 GO:0034724 DNA replication-independent nucleosome organization The formation or destruction of chromatin structures, occurring outside the context of DNA replication. BP 0.00179829069004794 2 53 1620 1389949 0.0374740576055151 GO:0034508 centromere complex assembly The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere. BP 0.0018660136435613 2 54 1620 1389949 0.0376701504293937 GO:0043486 histone exchange The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits. BP 0.00193493406372976 2 55 1620 1389949 0.0378778001566492 GO:0051259 protein oligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. BP 0.00212063072840667 4 454 1620 1389949 0.0402919838397267 GO:0006303 double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear. BP 0.002771271478563 2 66 1620 1389949 0.0511497535757628 GO:0016458 gene silencing Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression. BP 0.00320969008175692 3 248 1620 1389949 0.0575961053559714 GO:0000726 non-recombinational repair A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA. BP 0.00337700991920372 2 73 1620 1389949 0.0589607677785298 GO:0040029 regulation of gene expression, epigenetic Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. BP 0.00350755911483043 3 256 1620 1389949 0.0596285049521173 GO:0043044 ATP-dependent chromatin remodeling Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. BP 0.00365382223852434 2 76 1620 1389949 0.060522286309916 GO:0045638 negative regulation of myeloid cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. BP 0.0045452658295242 2 85 1620 1389949 0.0715814514285297 GO:0034622 cellular macromolecular complex assembly The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level. BP 0.00579634992697745 5 961 1620 1389949 0.082674750062681 GO:0044085 cellular component biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. BP 0.00609875974665842 9 2781 1620 1389949 0.082674750062681 GO:0007218 neuropeptide signaling pathway The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor. BP 0.00611002699426769 2 99 1620 1389949 0.082674750062681 GO:0006461 protein complex assembly The aggregation, arrangement and bonding together of a set of components to form a protein complex. BP 0.00627099497379469 6 1387 1620 1389949 0.082674750062681 GO:0070271 protein complex biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a protein complex. Includes the synthesis of non-protein components, and those protein modifications that are involved in synthesis or assembly of the complex. BP 0.00627099497379469 6 1387 1620 1389949 0.082674750062681 GO:0010629 negative regulation of gene expression Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. BP 0.00748935346869035 6 1441 1620 1389949 0.0967624468154793 GO:0045296 cadherin binding Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion. MF 2.62670112135163e-05 5 302 269 240069 0.00351977950261118 GO:0046982 protein heterodimerization activity Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer. MF 0.000175834728118426 5 453 269 240069 0.00793421173238072 GO:0050839 cell adhesion molecule binding Interacting selectively and non-covalently with a cell adhesion molecule. MF 0.000177631605948822 5 454 269 240069 0.00793421173238072 GO:0098641 cadherin binding involved in cell-cell adhesion Any cadherin binding that occurs as part of the process of cell-cell adhesion. MF 0.000328373351235208 4 286 269 240069 0.00888961507760864 GO:0098632 protein binding involved in cell-cell adhesion Any protein binding that is involved in cell-cell adhesion. MF 0.000373750588716363 4 296 269 240069 0.00888961507760864 GO:0098631 protein binding involved in cell adhesion Any protein binding that is involved in cell adhesion. MF 0.000398042466161581 4 301 269 240069 0.00888961507760864 GO:0042393 histone binding Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity. MF 0.00122332999233715 3 184 269 240069 0.0204907773716473 GO:0031490 chromatin DNA binding Interacting selectively and non-covalently with DNA that is assembled into chromatin. MF 0.00542946262553169 2 97 269 240069 0.0680971067951879 GO:0008528 G-protein coupled peptide receptor activity Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. MF 0.00926490338699152 2 128 269 240069 0.0713221717599779 GO:0001653 peptide receptor activity Combining with an extracellular or intracellular peptide to initiate a change in cell activity. MF 0.00940390926638492 2 129 269 240069 0.0713221717599779 GO:0046983 protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. MF 0.00946464426186912 5 1133 269 240069 0.0713221717599779 GO:0043566 structure-specific DNA binding Interacting selectively and non-covalently with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding. MF 0.0101128452495491 2 134 269 240069 0.0713221717599779 GO:0045295 gamma-catenin binding Interacting selectively and non-covalently with the gamma subunit of the catenin complex. MF 0.0122570535241663 1 11 269 240069 0.0821222586119142 GO:0003682 chromatin binding Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. MF 0.0166694365018349 3 474 269 240069 0.0992652419108055 GO:0015125 bile acid transmembrane transporter activity Enables the transfer of bile acid from one side of the membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. MF 0.0166769559782798 1 15 269 240069 0.0992652419108055 GO:0070300 phosphatidic acid binding Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. MF 0.0177788492974577 1 16 269 240069 0.0992652419108055 GO:0072349 modified amino acid transmembrane transporter activity Enables the transfer of modified amino acids from one side of a membrane to the other. MF 0.0177788492974577 1 16 269 240069 0.0992652419108055 GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. CC 9.63827490643547e-07 5 102 667 396679 0.000118326390058771 GO:0044815 DNA packaging complex A protein complex that plays a role in the process of DNA packaging. CC 1.27920421685158e-06 5 108 667 396679 0.000118326390058771 GO:0032993 protein-DNA complex A macromolecular complex containing both protein and DNA molecules. CC 1.27769624254441e-05 5 173 667 396679 0.000787912682902386 GO:0000785 chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. CC 0.00107772495837709 5 450 667 396679 0.044438594286182 GO:0000784 nuclear chromosome, telomeric region The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins. CC 0.00150917428823007 3 132 667 396679 0.044438594286182 GO:0044454 nuclear chromosome part Any constituent part of a nuclear chromosome, a chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. CC 0.00164997577791202 5 496 667 396679 0.044438594286182 GO:0000228 nuclear chromosome A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. CC 0.00219729384139933 5 530 667 396679 0.0446662521767196 GO:0000788 nuclear nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures. CC 0.00232462266667499 2 42 667 396679 0.0446662521767196 GO:0005913 cell-cell adherens junction An adherens junction which connects a cell to another cell. CC 0.00241439200955241 4 327 667 396679 0.0446662521767196 GO:0000781 chromosome, telomeric region The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins. CC 0.00274644049023957 3 163 667 396679 0.0461901355176655