CLUSTAL X (1.83) multiple sequence alignment Ag_TOLL10 ------------RQDVRLWAHARYGVRLVKDPIIVGGRKEPDSDRLYDCYLVHSVHDSDF Aa_TOLL10 ---------------------------------------------LYDSYVVYSIHDNEF Ag_TOLL11 ------------RQDVCLWAHSRYGVRLCKDPLTALERCE-DSEKLYDAYLLYSAADADL Aa_TOLL11 ---------------------------------------------LYDGYLVYSAADADM Dm_Toll-9 KRWHIHYYYSSLKSAALLSSASKESVNKFTNI-----SQR-DPSAVYDIFISYCQNDRTW Aa_TOLL9B ---------------------------------------------MYDVFVSYSEQDRQW Ag_TOLL9 ---HIKYFFKIMKNSAVLSFFNDEKLYLDKSG-----LLK-EADFHYDVFVSYSNADRSW Aa_TOLL9A ---------------------------------------------QYDVFVSYSDNDRAW Dm_Toll-2 ------------RESVRMWLFAHYGVRVCEPR------FE-DAGKLYDAIILHSEKDYEF Dm_Toll-7 ------------RESLRIWLFAHYGVRVFGPR------CE-ESEKLYDAVLLHSAKDSEF Ag_TOLL7 ------------REPLRFWLFSRYGVRVFGPR------CE-DSEKLYDAILLYSAKDAEL Aa_TOLL7 ---------------------------------------------LYDAIFIYSAKDAEY Dm_Toll-3 ------------RQPVLVWFYEHGVCLSLAAK-----REL-DKDKRFDAFLAFTHKDEAL Dm_Toll-4 ------------RQPIMIWFYEHEICLSLAAR-----REL-DEDKKYDAFLSFTHKDEDL Dm_Toll-8 ------------RQEMRVWCHSRFGV-RLFYNAQKDVDKN-EREKLFDAFVSYSSKDELF Ag_TOLL8 ------------RQEMRVWFHSKFGV-RLFYR-NADIDKN-ERDKLFDAFISYSSKDEAF Aa_TOLL8 ---------------------------------------------LFDAFVSYSSKDEAF Dm_Toll-6 ----------CYRHELKIWAHSTNCLMNFCYKSPRFVDQL-DKERPNDAYFAYSLQDEHF Ag_TOLL6 ------------RKELKVWVHS-----GLCYKSGTFVNEY-DKDRLYDAYITYSLQDEHF Aa_TOLL6 ---------------------------------------------LYDAYIINSLQDEHF Aa_TOLL4 ---------------------------------------------QYDAFISYSHRDENF Dm_Toll-5 ------------QQELKIWLYNNNLCLWWVSE-----EEL-DKDKTYDAFISYSHKDEEL Dm_Toll-1 ----------KFQTEIKIWLYAHNLLLWFVTE-----EDL-DKDKKFDAFISYSHKDQSF Aa_TOLL1B ---------FAYHNEIKIWLFKRNLLMCWVTE-----QEV-DKDKQFDAFISYSHHDEDF Aa_TOLL5B ---------------------------------------------LYDAFVSYCHQDEEF Ag_TOLL5A ----------KYSLEIKVWLFKHNLLQWLVTE-----EQI-DMDKRYDAFISYSHKDEEF Ag_TOLL1B ----------KYNLEIKVWLFKHNLLQWFATE-----EQI-DMNKRYDAFISYSHKDEEF Ag_TOLL5B ----------KFNLAIKVWLFRHNLLQWLVTE-----EHT-DMNKRYDAFISYSHKDEDF Aa_TOLL5A --------FFRYQTEVKVWLFTHNLFLSLITE-----EEL-DKDKLYDAFISYSHLDEEF Ag_TOLL1A --------YYTYKLELKVWLFKHGLCLWLVAE-----EEL-DRDKLYDAFVSYSHKDEAF Aa_TOLL1A ---------------------------------------------LYDAFISYSHKDEEF * . * Ag_TOLL10 VGRLLGAELQL--HGYSVCQHHRDVHPGA-FLADSLQSAADSARKLLLVVSMNFLQTEWS Aa_TOLL10 VGRLLGAELQH--YGYSICLHHRDVHSNT-FLSDSLQNAADASKKVILVVSMNFLQNEWS Ag_TOLL11 VTSQIGQELEH--HGYGMCLHYRDVHGGAGFLGDTVQSAADASRKLVLFVSVKFLQLEWS Aa_TOLL11 VTSQIAQELEH--NGYALCLHYRDIHSAA-FLADSLQGAADASRKLILFISVKFMQLEWS Dm_Toll-9 VLNELLPNVEE-TGDVSICLHERDFQIGV-TILDNIISCMDRSYSLMLIISSKFLLSHWC Aa_TOLL9B VLDELLPNLER-TEDIAVCLHERDFQVGV-SILENIIYCMDQSRTLLLVMSESFLLSHWC Ag_TOLL9 VLDHLLPNME-GVSQINLCLHERDFEVGY-GILENIISCMDRSRCLMLIVSESFLLSHWC Aa_TOLL9A VLDEMLPSLEQEDL-ISVCLHERDFEVGY-GILENIISCMDRSRCLMLIVSESFLLSRWC Dm_Toll-2 VCRNIAAELEHGRPPFRLCIQQRD-LPPQ-ASHLQLVEGARASRKIILVLTRNLLATEWN Dm_Toll-7 VCQHLAAQLETGRPPLRVCLQHRD-LAHD-ATHYQLLEATRVSRRVVILLTRNFLQTEWA Ag_TOLL7 VARSIAGELENGRPPLRLCLQHRD-LPED-ASHLQLLEASRASRRIVVLLSRNFLQTEWS Aa_TOLL7 VARNIAAELENGRPPLRLCLQHRD-LSED-ATHLQLLEASRASRRIVMLLSRNFLQTEWS Dm_Toll-3 L-EEFVDRLERGRPRFQLCFYLRDWLAGE-SIPDCIGQSIKDSRRIIVLMTENFMNSTWG Dm_Toll-4 I-EEFVDRLENGRHKFRLCFYLRDWLVGE-SIPDCINQSVKGSRRIIILMTKNFLKSTWG Dm_Toll-8 VNEELAPMLEMGEHRYKLCLHQRDFPVGG-YLPETIVQAIDSSRRTIMVVSENFIKSEWC Ag_TOLL8 VAEELAPMLENEDPSYKLCLHYRDFPVGA-YIADNILQAVESSRRTIMVLSENFIKSEWC Aa_TOLL8 VAEELAPMLENGDPSYKLCLHYRDFPVGA-YIADTIVQAVESSRRTIMVLSENFIKSEWC Dm_Toll-6 VNQILAQTLEN-DIGYRLCLHYRDVNINA-YITDALIEAAESAKQFVLVLSKNFLYNEWS Ag_TOLL6 VSQILTSTLEN-DIGFRLCLHYRDLNANA-YLADTIVEAVESSKRAILVLSKSFLYNEWT Aa_TOLL6 VNQILASTLEN-DIGFRLCLHYRDFNINT-YIADTIVEAVESSKRAILVLSKNFLYNEWT Aa_TOLL4 IAHELVPKLEAPPQKFRLCIHLRDFVPGM-LIETQILNAIATSRRTIVYVTQNFLRSEWT Dm_Toll-5 ISK-LLPKLESGPHPFRLCLHDRDWLVGD-CIPEQIVRTVDDSKRVIIVLSQHFIDSVWA Dm_Toll-1 IEDYLVPQLEHGPQKFQLCVHERDWLVGG-HIPENIMRSVADSRRTIIVLSQNFIKSEWA Aa_TOLL1B VANHLVPTLEQPPMNFRTCWHVRDWTPGE-LITEQMTRSISESRRTIVVLSKGFLESVWA Aa_TOLL5B VSSTLVPRLETAPMNLKVCWHMRDWNPGE-VITTQIVHSIENSRRTIVVLSRDFLESSWG Ag_TOLL5A VTGQMLPRLESEELNFKICWHVRDFMPGE-MIASQITKAVEDSRRTIIILSHNYLESVWG Ag_TOLL1B VTKELLPKLESEELNFKICWHVRDFMPGE-MIANEITKAVEESRRTIIILSLNYLESVWG Ag_TOLL5B VTKELLPRLESEELNFKICWHVRDFVPGE-MIANEIAKAVEESRRTIIILSLNYFESMWG Aa_TOLL5A IVDELIPKLENDPMNFKTCWHVRDFMPGE-MIMTQIVKSIDASRRTVIVLSKNFLESSWA Ag_TOLL1A ITEHLVPTLERDPMNFKLCWHVRDWTPGE-MISSQISSSVEQSRRTIIVLSSSFLESLWG Aa_TOLL1A ITEHLVPTLEKEPMNFKTCWHVRDWMPGE-LIPTQIAKSVEDSRRTIVVLSTNFLESVWG : : :: * ** : : :: :: : * Ag_TOLL10 QPQFRVALQSVIESIRPAHRRHKIVLVLT-APVEIVA-MDPIMHLLIRTCTV--ACWGER Aa_TOLL10 QPQFRVALQSVIENIRPAYRRHKIVVVLT-APVELVA-MDPIMNLLIRTCTV--ACWGER Ag_TOLL11 QPEFRAALQAALELIRPSRRKQRIVLITS-VPGSMLA-MDPIMDILARTCTV--IAWDDR Aa_TOLL11 QPEFRAGLQAVLELIRPSRRKQKLILITS-VPQSMLT-MDPIMDILTRTCTV--ISWDDR Dm_Toll-9 QFEMYLAQHRIFEV-----SKEHLILVFL-EDIPRRK-RPKTLQYLMDVKTY--IKWPTA Aa_TOLL9B QFEMHLAQHRLLET-----RREQLILVLL-EDIPKVK-RSKTLQYLMKTKTY--IIWPQQ Ag_TOLL9 QFEMHLAQHRLLET-----RRDELILVLL-EDIPRRK-CPKTLSYLLKTKTY--IKWPTK Aa_TOLL9A QFEMHLAQHRLLET-----RRDELILVLL-EDIPKRK-CPKTLSYLMKTKTY--IKWPRQ Dm_Toll-2 RIEFRNAFHESLRG-----LAQKLVIIEE-TSVSAEAEDVAELSPYLKSVPSNRLLTCDR Dm_Toll-7 RCELRRSVHDALRG-----RPQKLVIIEE-PEVAFEAESDIELLPYLKTSAVHRIRRSDR Ag_TOLL7 RCELRRAVHDALRG-----RPHKLVVVEEGGGVLLEAENDVELVPYLKTTTVTRVRRGDR Aa_TOLL7 RCELRRAIHDALRG-----RPHKLVVLEE-VGVILEAENDVELVPYLKTTTVNRIKRSDR Dm_Toll-3 RLEFRLALHATSRD-----RCKRLIVVLY-PNVKNFDSLDSELRTYMAFNTY--LERSHP Dm_Toll-4 RLEFRLALHATSRD-----RCKRLIVVLY-PDVEHFDDLDSELRAYMVLNTY--LDRNNP Dm_Toll-8 RFEFKSAHQSVLRD-----RRRRLIVIVL-GEVPQKE-LDPDLRLYLKTNTY--LQWGDK Ag_TOLL8 RFEFKSAHHQVLRD-----RRRRLIVILL-GEVPQKD-LDPDIRLYLKTNTY--LQWGDK Aa_TOLL8 RFEFKSAHHQVLRD-----RRRRLIVILL-GEVPQKD-LDPDIRLYLKTNTY--LQWGDK Dm_Toll-6 RFEYKSALHELVK------RRKRVVFILY-GDLPQRD-IDMDMRHYLRTSTC--IEWDDK Ag_TOLL6 RFEFKGAIHEVLK------RRRKLIIILY-GDLPQRD-LDADMRLYLRTNTC--IEWDDK Aa_TOLL6 RFEFKGAIHEVLK------RRRKLIIILY-GDLPQRD-LDADMRLYLRTNTC--IEWDDK Aa_TOLL4 RHEFRLAFEQSLRE-----NRTRLIVILA-TDVQRLDQLDPQLRVFFSTTTY--LRADDE Dm_Toll-5 RMEFRIAYQATLQD-----KRKRIIIILY-RELEHMNGIDSELRAYLKLNTY--LKWGDP Dm_Toll-1 RLEFRAAHRSALNE-----GRSRIIVIIY-SDIGDVEKLDEELKAYLKMNTY--LKWGDP Aa_TOLL1B RMEFRTAHLNSIAE-----RRSRVIVILY-EHFGDIEQLDADLKAYLRTNTY--IRWGDP Aa_TOLL5B QLEFRTAHVSSMAE-----KRVRVIIIIY-GDLGDEDRIDSEMKAYLKTNTY--IKWGDP Ag_TOLL5A QMEFNTAYLQSLED-----KRNRVIPIIY-QDIGDIDQLDPELQAYLKTNTY--VRWDDP Ag_TOLL1B QIEFSTAYLQSLAD-----KCNRVIPIIY-QDIGDIEQLDPQLQAYLKTNTY--VRWDDP Ag_TOLL5B QMEFSAAYLQSLVD-----KHNRVIPIIY-QDIGDIDQLDPQLRAYLKTNTY--VRWDDP Aa_TOLL5A KQEFRQAHVQSMED-----NRVRVIVVIY-EEIGDIDSLDGELKAYLKTNTY--VKWGDP Ag_TOLL1A QLEFRTAHLQSMAE-----RRNRLIIIIY-GDIGNIYDLEPELRAYLHTNTY--VRWGDP Aa_TOLL1A RMEFRTAHLTSMEE-----KRARVIVIIY-GDIGSIEDLDPELKAYLKMNTY--VKWGDQ : : . .:: : : . Ag_TOLL10 K------FWDKLRYALPDVPKDRVPAKLGDITRSPANLRYTPAPTS----- Aa_TOLL10 K------FWDKLRYALPDV-------------------------------- Ag_TOLL11 R------FWDKLRFAMPDLGRDGGSVNKASHRKNINIRYTPAPTNNLM--- Aa_TOLL11 R------FWDKLRFAMPDI-------------------------------- Dm_Toll-9 K-EDRKLFWKRLKRSLEVIGINSREISV----------------------- Aa_TOLL9B S--TRKLFWKRLRNAISES-------------------------------- Ag_TOLL9 SVHEQALFWKRLHKTLLTSKA------------------------------ Aa_TOLL9A QTRDRELFWKRLRKALMST-------------------------------- Dm_Toll-2 Y------FWEKLRYAIPIELS-PRGNNYTLD----HHERFKQPVSPG---- Dm_Toll-7 H------FWEKLRYALPVDYPTFRGNNYTLELDHHNHERVKQPASPGLLYR Ag_TOLL7 H------FWEKLRYALPVEAP-YRGNNYTID----HHERVKQTGGGG---- Aa_TOLL7 H------FWEKLRYALPVD-------------------------------- Dm_Toll-3 N------FWNKLIYSMPHTKLR----------------------------- Dm_Toll-4 N------FWNKLMYSMPHASHLKRSRSDAET----KV-------------- Dm_Toll-8 L------FWQKLRFALPDVSSSQRSNVAGQS----CHVPI----------- Ag_TOLL8 L------FWEKLRFALPDVPNNQR--------------------------- Aa_TOLL8 L------FWEKLRFALPDV-------------------------------- Dm_Toll-6 K------FWQKLRLALPLPNGRGNNNKRVVSGCLSGRTPSVNMYAT----- Ag_TOLL6 K------FWQKLRIALPHVKKSNCLNKRSAI----NIYAT----------- Aa_TOLL6 K------FWQKLRIALPHV-------------------------------- Aa_TOLL4 K------FWQKLVYAMPHR-------------------------------- Dm_Toll-5 L------FWSKLYYAMPHNRRVLKGQK------------------------ Dm_Toll-1 W------FWDKLRFALPHRRPVGNIGNGALI----KTALKGST-------- Aa_TOLL1B W------FWDRLQYAMPHAPRIRG--------------------------- Aa_TOLL5B W------FWQKLRYAMPHP-------------------------------- Ag_TOLL5A W------FWDKLHYAMPRKRCPKHDQATGNI----PMLS------------ Ag_TOLL1B W------FWEKLHYAMPHKRRLKGVQGTDNM----CMES------------ Ag_TOLL5B W------FWDKLHYAMPRKRRPKDVQTTDNM----RMAS------------ Aa_TOLL5A W------FWQKLRYAMPHPLKVKGIKSAVSE----IHLQQVTT-------- Ag_TOLL1A W------FWDKLRFAMPHPPKVRGASGTAST----VVKSGVSTAGGLFMKQ Aa_TOLL1A W------FWDKLRYAMPHP-------------------------------- **.:* ::