>CqSRPN26 Cp:SRPN33 CPIJ011902 SERPIN1 protein supercont3.353 303384 304687 Cp_SRPN26 'SRPN' ----------------------------------------------MFTIKQALFITVSS FYLALLSDSQQL---------------------------------------LEKKKVTVD IDKSL-------------------------------------------TKYLVKFYKHR- -----LVEG----------QNNALAPLLD----------------LYALV------LLYK VS--DAS-------AKTDLHTLLGIP-EDAEDGTMDKFEANIRLYL-------------- -----------------------------------------ERFGGNSVFGTQLFVDSR- ---IKGVTRELQ-DKKFLTTS---------TVNFGQ----KIE-FQQKI----------- ------------------------------------------------------------ -----------------------------------NSWMSG------------------- ------------------------------------------------------------ ----------LAMSNNHH------------------------------------------ FVHSFN---FDD----N------------------TVSLILQVVAVR--WKLPLAL---S TP-SKAFLGD-------------QVKYLEGTLE-ASYA-KID-------K-LGIQVLEPI PS--------------------DSDVKLWLILPN-----SMVTFINKTV--GEETLDEIA KSLR--------NKQQFVKMSIPQVNIEFNSEENAFLQNNF----------------HVL SSMFSSPSIRLELD---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KEDKHPIKGFLMHCLFQFVEDNSARVPQQ----------------- --------------GTLAVNFDKPFTVMALTKDTNI-----PLLMASF---FSVKDKMLA MEDEEQSLAEQVAQEELANREDL--------------------------- >AaSRPN26 Aa:29 AAEL003182 ---------------------------------------------MCSTGFCLVFFLAQV VFQMNYSEQQTTV--------------------------------------VMENGAISE SEINVDIVM---------------------------------------KQYILKFYTKR- -----FVEG----------QNLVVAPLLT----------------FRVFM------SLYK AM--DAS-------AKFDLHSLLGIQQGTSVEKMS--EIEAFANKH----TL-------- -----------------------------------------PVDEKQISVETRLYYDK-- ---SIGNARSVLTAKSLKP----------IGTSFSD----KRA-FCEKV----------- ------------------------------------------------------------ -----------------------------------NSWIRN------------------- ------------------------------------------------------------ ----------APIKGTDN------------------------------------------ LVHDYD---LNN----E------------------TQAFVAGALSI--YWNTQLKSS--T DQ-KGFQGEN--------------VKFLEGSIS-AGYA-KLD-------N-LKVEVVELI SD-------------------KVDGVKLWLIMPD--RA-SSIKDFNDQL--SVESIRQIE NGLT--------AQKVDVSLALPMVTIEYNSQEDAYVTEVF----------------EVF SSLFTKPSVKLVDG---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KDDLYVIKNFLMKCILRFVESDASADSKAQSTGMLVK--------- --------------------FDRPFVMMMLSKEGNV-----PILLANY---FSPTDKLRA LEAKERRLKAEANEHLDL-------------------------------- >DmAcp76A Dm:30 Dm:N8738 CG3801 Acp76A Dm_Acp76A --------------------------------------------------MGNHQVIFLV LCTS-----------------------------------------------LLFQNTIQ- ------------------------------------------------QNVSFQLIREI- -----DRYT---------PENFVLSVLNI----------------EMILF------EIHA AK--AVE-------SNNDLERSLIINFGYSEARQE--VLDWGLRYK-------------- -----------------------------------------KASSAKFQMANKVAVSQKL P--LSQKLRLV--NEVLMTSA--------KKYDVTK----DVR-PSKLM----------- ------------------------------------------------------------ -----------------------------------DEWLSS------------------- ------------------------------------------------------------ ----------HLDGVLAN------------------------------------------ FVQEKK---LNA----G------------------ENIVAISGMTVTPLWASHFQSEI-- ---NRYFVNNPGTGYASKDPT--CVPMMHSLSS-FETM-STD-------E---AKGIYIP FS--------------------SANLGMLILLPR--KG-VTCKDILDNL--NNQINVEYN D-----------HKDVHLLL--PIFKEKFDYNIAKFFNG------------------INI EDTFKDSAFK-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SKAKIKINNFRVNHGIRFQPILRLEVVDDIDTGKTET--------- ------------------FEVNRPFVFVIKDKINVY-------AVGRI---ENLDGLTDK VNCSKKYADLKS-------------------------------------- >DmSpn75F Dm:19 Dm:N7459 CG32203 Dm_Spn75F ------------------------------------------MARTTELKLAMLDPAKCQ LLAVVEDQRFKTP--------------------------------------LKCNERSNV LCHELS------------------------------------------SDIKVHLVSSAD CKGYGSGRRCHQLSKGRLARNFVYSPIAI----------------RQALG------LLYL SK--DNV-------TDQQLESALQLT---GLNQEE--IISLFKEAR----EKV------- -------------------------------------------AQEQFTMGNRIYLSPDY N--ASPNITQL--SENLGVEV--------KNMTFSG----DQS-AASEI----------- ------------------------------------------------------------ -----------------------------------KKWLNK------------------- ------------------------------------------------------------ ----------WIGKAGGN------------------------------------------ LFGKND---ISQ----T------------------TQIVAVQGMSYSCVWKNRETALT-N RT-FTLLRQN-------KKPFVYTTQMMYTEAP-MDFF-NND-------Q---VRGVMVP FK--------------------NSDMGMLVLLPR--PR-YSTQQILYSL--DTILKIKLR R-----------SKKTHLFL--PKFKVSESVDLNMALKA------------------LGI QNLFTN------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------TNAANFKQYNSFDADQNRVLMTIDVGDDFDDRV--------- ------------------VYVNRGFVFVVKDKSTIY-------MIGRMDATGAPETVADF PPTQRYHKDIDGSPLNVGCSAGLEMHGIKDVKSGRRCRSPELQYTALISG >CqSRPN23 Cp:SRPN21 CPIJ007025 FXa-directed anticoagulant supercont3.133 764214 765633 Cp_SRPN23 'SRPN-nonINHIB' ----------------------------------------------------MLRCLLIL VASFTPGI-------------------------------------------VSDSPKQLP KDYQ--------------------------------------------SEFAWKFYKQI- -----SQSF---------ETNIISSPYHI----------------REAFA------CLSN VSLPSNT-------LSKEFQKAILLP---RTNLIH--TRYDLQRER-------------- -----------------------------------------FQCRDELRVATLAAGLGTK H-VLDGMFRSTM-DHCRMFQT---------RVATDH----AIK-MTQKL----------- ------------------------------------------------------------ -----------------------------------NGVFWN------------------- ------------------------------------------------------------ ----------ASNNEMRK------------------------------------------ FLSPND---IDV----D------------------WDFLIMNSVVLSAQWKYQFKPSD-T TV-CPFYASK-------SKQI--YTEFMQVEGY-FRYG-YFS-------Q-WNLAAVEVP FK-------------------DGSPYSCLLMHS---ID-GSLSNMMKNY--DHNRFREIY QKLN--------EGKTTIIM--PKSIIRVSLKSSNILKS------------------LGL KTPFTEKIWKVFN----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SPNGVSLGEFMQKVTIQFESGVGQIVKNIPGRDLGNQ--------- ------------------FIAHEPFVFTVFDRQELT-----PIIVGHL---IEPTKTEKP KSNHLMCQNPPSWTFKG--------------------------------- >AaSRPN23 Aa:24 Aa:N36631 AAEL002704 --------------------------------------------------MNLWIIGFCS IYFACS---------------------------------------------VRSQFTSVP VSYDAQNDH---------------------------------------NEFSWNAFKKV- -----FTDY---------KENFVMSPYSL----------------RRLFSCFQGVKLLTS AS--GTN-------LQQELSNVLKIA----PNQQP--SGQDHRPYV----EQWVR----- -----------------------------------------YSSAKYLNRTAMAVAIGSE K--VSTVYESII-NNCVIYTG---------HLQPSN----AQR-MGQVI----------- ------------------------------------------------------------ -----------------------------------NDALKN------------------- ------------------------------------------------------------ ----------ITNNAVQS------------------------------------------ YLTDTD---INP----N------------------WKFFAIDSWQFEGLWKYKFQEEF-S AT-CYFYASK-------EKKG--LTKFLYLEEM-LKYG-NFP-------E-WNVQAVDLP YH-------------------DQSPLSCLLVMP---LD-GNYESLINSM--NQSRFKDVL SKLK--------ETKTTVRI--PQFGLQTTVPGRQLLES------------------MGM KVPFNQGVFKVFE----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------QGQDVALGEIVQKMEMSIAADGEKQAQSFVDKRQDKQ--------- ------------------FTAHQPFLFVVYDRNELV-----PILVGFY--LKTPPEAAMG LEDKQKCDDPPVGYQ----------------------------------- >AaSRPN25 Aa:27 AAEL007420 -----------------------------------------------MYLKVVILFSLQL VCYT-----------------------------------------------QGGTPPSKP MAIDYQ------------------------------------------AEFAWDLYKKL- -----QLGF---------TQNLAIAPYSL----------------RKIFV------CLQQ LT--DSE-NPASAALSEQLKNVFKFN---PKGKLPDLVRSRYSAQW----TALER----- -----------------------------------------EKGINTTTLAAVIGREKKT K--LFRDLPNSC--AIFAASL-------------------TPG-SPKQM----------- ------------------------------------------------------------ -----------------------------------SRWFNAAMRN--------------- ------------------------------------------------------------ ----------ISKSGVQN------------------------------------------ FLSTSD---IDR----D------------------WDFLVADSWIFKGLWRYQFEEEH-K TT-CNFYTNS-------TSKG--LMRFMYLQEY-LKHGYFLE---------WNVQAVELP LH-------------------HGSSFSCMLMMP---VK-ADIGVLIKSL--NHRRFKDIY SKMS--------VSKTDVRL--PQFTLRIKLSAKSILQQ------------------FGF NAAFNESVFHVFD----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------NKNAVPLGDVIQKVKLVMDHDGEQSAKMYVDRRMGNL--------- ------------------FIAHQQFIFVIFEKTQLV-----PIIVGHMVTASTPKDIGPE SDEISCDKPPRY-------------------------------------- >AgSRPN14 Ag:19 14 ENSANGG00000019032 ENSANGP00000021521 ENSANGT00000021521 2L28D TCLAG012312 agCP3574 Ag_14 ----------------------------------------------MWYGTVVLFLLWVL AESGSGV--------------------------------------------GGLTQLRFP YST---------------------------------------------TNFSLSLYKAA- -----FKPE----------QNVVVAPFTL----------------QNSVA------MLYS IA--TGT-------TRDRLREVFGLP----ANFTE--FIINQKLLH----YTLSD----- -----------------------------------------AGGSEGFRMKNRIIVNGFR E--VDARMRDIM-HEDLDTVL--------MYFDFAQ----REG-VVRRA----------- ------------------------------------------------------------ -----------------------------------NHFLSM------------------- ------------------------------------------------------------ ----------RTNGLIRD------------------------------------------ TLFLGD---VPK----Q------------------LQMIQLSAGSFRPPFASGFDARD-T IA-RDFRTGW-------IDKLY-QTTTMFKEGD-FRFA-RIP-------E-LEIEVLELP FH-------------------SRSDSALWIMLPD--RD-AELDRIVKAL--EPEHFDAIQ AHFS--------MKRAGIVV--PVFSIKTEFNATDFLRDT-----------------IGL DALFRLRELRFF------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DDHDSALDGVMHRAAISVHERSAEAGGVATVHSFSKR--------- -----------SAPAAYQFYVGRSFLFALVKRSSKQ-----LLFIGHL---YRPHDLVEV -------------------------------------------------- >AaSRPN14 Aa:23 Aa:N36625 AAEL002731 14 ----------------------------------------------------MNFLGWIT TILVAFASTC-----------------------------------------YGGGQLRFP YGD---------------------------------------------TNFSLSVYKAA- -----FSPE----------HNIVVAPFVL----------------RNSVA------MLYS IA--TDT-------TQARLREVFGLP----SNFSE--FLTNQKELH----YML------- -----------------------------------------GGGGDGFRMRNRIILNGLR E--VDVHMRDVM-KEDLDTTL--------VYFDFSQ----REG-VVRRV----------- ------------------------------------------------------------ -----------------------------------NHFVNF------------------- ------------------------------------------------------------ ----------NTNRVISS------------------------------------------ MINLDD---VPK----H------------------LQVVQVCSASFKPQFASMFDTKD-T MP-RDFRSGM-------IEKLY-TTMTMFKRGD-FRFS-RIP-------E-LEIEVLELP FV-------------------KSSDAVMWVMLPD--RE-ASLETIMKAL--EPGHFDAIQ AHFQ--------MKRAEITV--PIFHIESEFNATEFLRQS-----------------MGL EVLFKQRDLRIF------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EDVDSSLDSVMHKAGMRFYERTADAGGATVVRSFNKR--------- -----S----AKLIAPYQFIVARSYLFVIVKKTNKQ-----ILFMGHL---YKPDDLMEV -------------------------------------------------- >CqSRPN14 Cp:SRPN22 CPIJ007026 serine protease inhibitor supercont3.133 767953 769248 Cp_SRPN14 'SRPN-nonINHIB' ----------------------------------------------------MRLLGWVT AACGIVA--------------------------------------------CCGSQLRFP YGD---------------------------------------------TSFSLAVYKAA- -----FDPD----------RNIVVAPFVL----------------RNSVV------MLYS IA--TDA-------VRDKLREVFGLP----TNFTE--FLTNQKELH----YTL------- -----------------------------------------GGGGDGFRMKNRIIVNGFR E--VDVHMRDVM-KEDLDTTI--------AYFDFIQ----REG-VVRRV----------- ------------------------------------------------------------ -----------------------------------NHFVNF------------------- ------------------------------------------------------------ ----------NTNRAVGG------------------------------------------ IVKIDD---VPK----H------------------LQLVQVCAASFRPPFASSFDPKD-T NP-RDFWSGL-------IEKLY-STMTMFKRGD-FRFS-RIP-------E-LEIEVLELP FI-------------------KSSDAVMWIMLPD--RD-ASLEAIMKAL--EPGHFDAIQ AHFS--------LKRAEITV--PLFSIESEFNATEFLQG------------------MGL DVLFKNRDLRVF------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EDVDSSLDSVMHRAGIRLHEKTADAGGASVVRSFNKR--------- -------------SSIYQYVVARSYLFVIVKKTSKQ-----ILFMGHL---HKPDDLVEV -------------------------------------------------- >DmSpn100A Dm:17 Dm:N2475 CG1342 OG:12 Dm_Spn100A -------------------------------------------------MKAVLCAIFVT LLAA-----------------------------------------------IGQGLPTQL EDENH-------------------------------------------GSFAGQVSQLIA LQLLKFNKD--------IDANQVHSPLGV----------------ASILA------MLAE AS--EGD-------TYSEFEQVFGYP----KDRTK--LRDAYKRIL----GSYQNR---- -----------------------------------------DAAVALPSFQTWLYIYRNN S--AREEFKDLL-EKHYYVDV---KDISRQEYDWNE----PNT-SLQLSEEKDNTDSTEG STEQSNSKDVIGFETLKRIKLDDEDIPAIPSDGYGQEIIDKEASKFDRDVDD-------- -----------------------------------KQYVEKPVAQAEAELLQKEQKQQAT TESELESQPEETTTLSVEKQEKPDMAAEENPAEKQQNKRSDQEESQIKNLEENETVQEEE KLAKIMAAPALTAGEPEKVRLPLQKLENAVKTAAKDGADEIMLALESHLPSVSRVNGARS LFQQDD---ITSALSANSITGRSAGSK--------SKMLLFNGLYYRGSWANPFYQLR-D GSDEFFFMTN-------EDAV--KAPMMHARGK-FQVA-DLP-------Q-VKARVLSLP YE--------------------TSRYALCIVLPD--ET-EGLSDVISQL--QTSDFLLAK KQFQ--------MKELHISM--PKFQVEETSRSEAMLKQ------------------MGL KKVFSRTEAQLSLLS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EDPDVHVDEIVQFVNVRVDEGGSSANSLSAATMQART-PSVESTVL PVPEPE----PELPGVERFEVNRPFAYFIVDCQEQF-----VLASGKI---YTPEFKEDL PSVSIEVELEQS-------------------------------------- >AgSRPN12 Ag:18 Ag:N25805 12 ENSANGG00000014436 ENSANGP00000016925 ENSANGT00000016925 2R8A agCP12184 Ag_12 -------------------------------------------------VVCALLAVVTP ACNALPKQRYS----------------------------------------RDGGEPRSL VGVST-------------------------------------------NIITSSLLKGA- -----AETS----------GNHVFSPIGF----------------SSILA------MISE GA--EGQ-------TLKELYDVFKFP----TDRDL--VRKAFDVSL----KRLSG----- -----------------------------------------QNPTDEPQFKTWFYIYKNN S--VLQAYKDVL-EQNYAVEV---RDIERNDYNFDE----PKT-SLDPVVVEEEIIEESN GPDGDNLVLEQGSNNSNSKDIVDFEVLKIKSALPVEDELRTDTGISTKYDEIDDENPKFD KNIDDKEYVDPTKIKEELAKKKMEAMNEVAADADLDDAKMK------------------- ------------------------------------------------------------ ----------KTPDSIDRVDHEQPEKMSLSLKKLGLDDEQEVMQAVESQGSRRKFNVRRS FLTGDIASALSG----NSLVGRKANLKDDEEQVNESKMLLFNGLYYRGSWATPFQQLR-T EE-SKFFTNT-------DER---PVMMMRSQGT-FGVG-KDE-------Q-LDAKFLELP YN--------------------NSRYSLLLMVPN--NK-DGLKELIKNF--NPDTLSTVQ KSLV--------QMPVQICI--PKFRIDTTSRAEKPLAK------------------LGL ITMF-TSKADLSGIT--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------TEQKIHVDELVQHVSIRVDEGSSSENALSATNIVEAK--------- ----------TIDDEQEQFTADKPFLFFVRDVVDDI-----VIVAGKI---TDIPYVD-- -------------------------------------------------- >AaSRPN12 Aa:22 Aa:N43770 AAEL003653 12 ----------------------------------------MLQCFVMYSILKCFQLLYTN YVSIPFFPFFTVLLVEL----------------------------------CGCLVSALP KDRHTKDVANEPLVGHST------------------------------NIITASLLKGS- -----VDSP----------ANQVFSPVGF----------------ASILA------MISE GA--EGQ-------TRQELYDVLKFP----ADREQ--VRSAFDESL----KRLSA----- -----------------------------------------QNPANEPQFKSWFYIYKDN T--IKPEYRDVL-QNSYYVDV---RDIERNDYNFDE----PKT-SLGSI------EPSID LTPDEEAIVVGQVVPSNNNSKDIIDFEDLKIKSVPLDNVRSDVGIATKFDEVEEGDNPKF DKNIEDKQYVEPTQIKEEIAKQKDEHTNEVL----DEPVLK------------------- ------------------------------------------------------------ ----------AAEDRVDQ-VVEDAPQKFSLSLKKLDGEEHETMHAVESQASRQRFNVRRS FLSGDVASALSG----NSLVGRKANAKEGEEDQNESKMLLFNGLYYRGSWASPFQVIN-S DV-GTFSVNG-------QQK---PVTMMRSSGT-FSIG-SSQ-------E-LDAKYIQLP YN--------------------NSRYSLMLMMPN--QA-DGLKDLIKNF--NCRSLSSAQ KELS--------EMPVQITM--PKFQIDTTSRAEKALAK------------------LGL INVF-TSKANLSGIT--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DEQKIHVDELVQHVSIRVDEGSSSETALSATNKVEAK--------- ----------TTGVEMEEFVIDRPFLFFVRDIVDDL-----VIVAGKI---NDVPALEE- -------------------------------------------------- >CqSRPN12 Cp:SRPN53 CPIJ016699 serine protease inhibitor, serpin supercont3.864 82392 90863 Cp_SRPN12 'SRPN-nonINHIB' -----------------------------------------------MSGLLLVATCACL VSALPPLQRF-----------------------------------------SRENDGDGP HLVGLST-----------------------------------------NVITASLLKGS- -----MESG----------ANQVFSPIGF----------------SSILA------MISE GA--EGQ-------TLQEFYDVFKFP----NDKVA--VRNAFDKSL----KRLNS----- -----------------------------------------QNPSNEPQFKSWFYIYKNN S--VKPGFRDVL-LNNYYVDV---RDIERNDYNFDE----PKT-SLGPI--EPSIDLTPD PAPTVVNTPAVVVPSNNNSKDIIEFEDLKIKALPVEDNVRAEVAINSKYDEVTEDENPKF DKNIDDKEYVEPNKIKEEIAKQKEEHTNEVLDEPLLKAIGE------------------- ------------------------------------------------------------ ----------VDHFVLDT------PQRMSLSLKRLEDDEHEIMHAVESQVSRRRFNVRRS FLSGDIASALSG----NSLVGRKADTSDGEQSE--SKMLLFNGLYYRGSWATPFQMK--S KP-GSFFVNG-------QES---QVMLMQTTGK-FGVG-SSQ-------E-LDAKFVEMP YN--------------------NTRYTLLVMVPN--RS-EGLKDLIKNF--NSDSLSSAQ KSLV--------QKSVQITL--PKFHIDTTSRAEKALAK------------------LGL ITMF-TSKADLSGIT--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DEQKIHVDELVQHVSIRVDEGASSELSLSAANAVEAKTGDDQDIEE VTTVAA----SADAAAERFVVDRPFVFFVRDTLDGT-----VIVAGKI---TDVPAADE- -------------------------------------------------- >DmSpn53F Dm:21 Dm:N711 CG10956 Dm_Spn53F ---------------------------------------------------MYVLLLILL GISRYRAQKN-------------------------------------------------- ------------------------------------------------SQLPDELYAAI- -----VNSF--------SNRNIMFSTEMI----------------RSSML------FIYV GV--EED-------ESEQIRKAMHYRGTHLSEYKP--KTQKIFAMS-------------- -----------------------------------------VKKAPVAKSLTRFYVRQNM K--MSTEYRVFM-RHTEGRAR---------NIAFAR------E-QLDEV----------- ------------------------------------------------------------ -----------------------------------NTFYSH------------------- ------------------------------------------------------------ ----------EMGEQIGQ------------------------------------------ VVKESW---WKP----N------------------SQGLLVNAIFFNLSWERTFNPEA-T YP-REFRVNA-------TKSV--MIPMMHEDSK-FAFG-ILG-------N-LKATAVLVP FS--------------------HGDLRMLLIKPD--QP-DGLAALQMKL--QAMNILSVA RNLT--------MMDVFVGI--PKFKIHSDLELSPAFEK------------------MGI KDIF-KPSKSFSTLLH-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RNTNFRIDGVIHVVTFEFQEQGIGTPSTDVGKFN------------ ------------------------YLKILKDTVLLF-----FFYFRQW------------ -------------------------------------------------- >CqSRPN18 Cp:SRPN16 CPIJ007020 serpin 18 supercont3.133 746260 747249 Cp_SRPN18 'SRPN-nonINHIB' ------------------------------------------------------------ ---------------------------------------------------C-------- ------------------------------------------------------------ -----FNPT----------ENVLCSPVVV----------------RLGLA------MFYQ VS--GTP-------IEEDLRTVLHLP----SDKST--SNTQQVQLH----DD-------- -----------------------------------------LTSSGALKIHTMICTSETR P--LDACFQDLLANHAPAVVL--------EPVDFTD----DVS-TARAV----------- ------------------------------------------------------------ -----------------------------------NGWI-Q------------------- ------------------------------------------------------------ ----------SERCEIDD------------------------------------------ LVTEGDVWSLET-----------------------LSVMMFNAVSLMTKWRLGFDPRL-T EQ-KEFKFLN-------KVQ---KVSMMHGIFK-ARYCYDLQ---------MRCKVVELP FE-------------------HSSNYNLLIILPD--DG-QCLADVVDAI--PEEYLNTMI DCLT--------EHWVDVQI--PRITVAMKTSVEDVLSK------------------QDC TGIFELKDLKVF------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------ADGKDQLDRFYQHCWFRMDENGAQLNAPLPES-------------- --------------PQVTFTADRPFLYVVRRANDSA-----VVMIGDYSIYVDPDEQY-- -------------------------------------------------- >AgSRPN18 Ag:20 18 ENSANGG00000021787 ENSANGP00000025479 ENSANGT00000029711 2L28D NOVEL Ag_18 ------------------------------------------------------MVLFSV LLTSS----------------------------------------------VAIDVAPDP TTDDAIVAAN--------------------------------------NKFTLEYFKAC- -----YDEK----------CNCAVSPYHV----------------RLALS------MFYP LA--GAA-------VQEDFQVAFGLP----EDVHA--AIEQQQRLA----QQL------- ------------------------------------------HDGQHLKALSFVLVEETL R--LDSEFERLF-HRTFQTTV--------EPVDLTD----DIP-SALAV----------- ------------------------------------------------------------ -----------------------------------NSFY-Q------------------- ------------------------------------------------------------ ----------RANTEIED------------------------------------------ FIGEGDVFSLPP----C------------------HKLMLFSGVSVLTPLAIRFNPAD-T AL-ELFQFIN-------APTQ--RVSTMHTTAF-VRRC-LHN-------E-LRCKVVDMP FD-------------------AASGLSMLVLLPY--DG-TELRQIVNSI--TPAHLAQID ERLQ--------SCWTDLKL--PKFFVREKTDPKQTLGK------------------LGY GGVFEIDDLHVFH----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DSGRTRLNGFIQHCYLAVSESGSGIPAPPDTP-------------- --------------SEFEFHANRPFMFLIRRTMDGN-----VLQVGNFSKYIDPDEQF-- -------------------------------------------------- >AaSRPN24 Aa:26 Aa:N3754 --------------------------------------------MEAHWKSLILLLVFRL IVGTDQG----------------------------------------------------- ------------------------------------------------NNFTLNLFKEV- -----YNLE--------SDRNFVLSPPII----------------RATLL------FLYL TA--NWN-------AALEIQQALQLP----PDKSE--AIVELKNYL----VKS------- -----------------------------------------IDDRAQLPVSSQIYRDPSE ---LSDILLELL-DGYIKPEV--------SLLSYND----DPS-AVISV----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LLKSTY---MPN-----------------------YNLLISTAFNFSATWRNPFNPQS-V RS-GMFKFSN-------GYH---QVSFMKKTAR-FGIL-KLE----------QLTALEML YN---------------------SDLSMILVLPN--DEDVPLSSLVKDF--NLKTYRTID SRLR--------QRFVEVAI--PRFVVDSSVPLGMSLAR------------------MGM VSSFLANAFDFY------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RYRGSGLGPMDHVGSIRVLEGGTVEVEEALEDTVPPA--------- --------------LLPSFRADRPFLFLVRNTTSKD-----ILVIGHH---SNFN----- -------------------------------------------------- >CqSRPN24 Cp:SRPN12 CPIJ006815 serine protease inhibitor supercont3.135 482533 488443 Cp_TBC 'SRPN-INHIB' ---------------------------------------MRRTAVISRQFNSTMAPGWLY LIVL-----------------------------------------------IACTSSSDP D-----------------------------------------------NTFSIELFRQT- -----YLRE---------QRNFVIAPPVL----------------RASLG------LLYQ VA--NRP-------VTSELQRVMHLA----PDKFQ--AAVDMKDSL----TSM------- -----------------------------------------AKGREHFETRCKMFRDQVE ---LSEKFSALF-LGYFKPEV--------EFSSLND--------QHAVI----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ TVTPKDYR-MRY-----------------------YDLKLSSDFHLNALFRNQFDPQK-T EN-KVFKALN-------GYW---MTSFMRQSAH-FGIA-RLD----------RLIALEIH YS-------------------WRSELTMMVIMPA--EEEGVLSELVQRF--DLATYRAID RALK--------QRYMEVSI--PKITLEGNVALGVPLAK------------------MGV VSAFLHNGFDLY------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RYRGSGLGVIEQRGSVVVAEGGSGAPNGTSRPSYLAV--------- -------------PHSPGFYADRPFMVLIRNRVTKQ-----ILAIGHY---SYFQL---- -------------------------------------------------- >CqSRPN38 Cp:SRPN55 supercont3.1079.pep ---------------------------------------------------MLILVVFTQ IMGTC----------------------------------------------YGNILGNY- ------------------------------------------------NQFELSLFRTI- -----YGSS--------KESNIILSAFSI----------------RATLS------ILYL LA--NKN-------TSEDMQKLFKTN--------------HFDRQP-------------- -----------------------------------------FEDGINLQIYSKAFIDQTL ---FNENFSTTF-QKHSGITL--------ETIDFEP----PRH-ENNSI----------- ------------------------------------------------------------ -----------------------------------DTWIDD------------------- ------------------------------------------------------------ ----------LTECTEPP------------------------------------------ LLSTTE---VTL----N------------------SSFLLWSAIWVRARWREPFDW---T TQ-QIFHYAN-------GDH---LVDMMFVENR-FEHA-EVD----------GLSAVNLP L---------------------DADLSMLVIVPT--RKSDQLSTVIARF--DHTMCLKIV RALK--------EKHVVLRM--PKFAVSSTVDVRKVLAA------------------IGL GALLGDYAFEVA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PGVNSPLSSMKQTTVIEVTENGLIAESSP----------------- --------------SPVFLTIDRPFIFFIRHVSTKS-----ILFIGQY---SQF------ -------------------------------------------------- >CqSRPN35 Cp:SRPN5 CPIJ003614 endopin-1 supercont3.50 1047495 1049032 Cp_TBC 'SRPN-INHIB' ------------------------------------------------------------ ---------------------------------------------------MKCPGFEAS VNSNHDVNLYSSS-----------------------------------NQFTFEFFKTV- -----YSPQ----------QNVVVSPLAM----------------FLILS------MVYH VA--NEK-------ASAELQQLLHLP----EDKQE--VMLHLSHFF----DQS------- -----------------------------------------RSNADGYRVSNVIFSKLT- ---LNPAFYLPL-EKRCGTE----------RVNLTN-----VD-VVALA----------- ------------------------------------------------------------ -----------------------------------NKWSLN------------------- ------------------------------------------------------------ ----------KTADMFS------------------------------------------- IVSPATINLMTM-----------------------MDIVMLNVISLNASWNTMFTP---S DQ-HTFYFLD-------GEQ---DVEFMEVDFE-GNYT-----------SQINYWTVEIP YE-------------------QSSNLSMIVIIPK--DN-ANIAQLVNSF--TLNDYQTID MKQE--------RKQISLEM--PKFSAKNELNLLEILMQ------------------SGV KEIFEDGRFAFG------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LTGKLRVVQFVQSAVIDVDETGTFAAAITIFGAIPFS--------- ----AD----GGGDNIMRVRVNRPFMYLIRNVISKE-----IVFIGHY---SMLGGEKCN EETV---------------------------------------------- >CqSRPN36 Cp:SRPN6 CPIJ003618 serine protease inhibitor supercont3.50 1267306 1273951 Cp_TBC 'SRPN' ------------------------------------------------------------ ---------------------------------------------------MDLYSSS-- ------------------------------------------------NQFTFEFFKTA- -----YSPQ----------QNVVVSPLAM----------------FLILS------MVYH VA--NEK-------ASAELQQLLHLP----EDKQE--VMLHLSHFL-------------- ---------------------------------------------------------RSV P--VQSGWKRCG-TE---------------RINFDQ------------L----------- ------------------------------------------------------------ -----------------------------------LTWV--------------------- ------------------------------------------------------------ ----------ATCKQMGP------------------------------------------ ---------LNK----------------------------------TADLFQIFTP---S DQ-HPFYFLD-------GEQ---DVEFMEVDFE-GNYTSQTK---------FK------P FN-------------------DNHQ-------SK--TE-RKSSSIGKQF--SLNDYQTID IKQE--------RKKIKLEM--PKFSAKNELNLLDILMQ------------------NGV KEIFEHGRFAFG------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LTGSLRVAQFVQSAVIDVDETGTFAAAFTIFGAVPFS--------- ----AG----GGADNIMIVRVNRPFMYLIRNVISKE-----IVFIGHY---SMLGGEKCN EETV---------------------------------------------- >CqSRPN37 Cp:SRPN9 CPIJ005429 fixed ------------------------------------------------------MLVLAV LLC------------------------------------------------LNQLLTATP LGTVCS------------------------------------------NRFTLDLFRKI- -----NTKN--------VRANYAFSPVAI----------------KSTLT------MLLP VA--NRK-------AAKAMQTVLGLS----EDAVL--VGQDVQRFL----K--------- -----------------------------------------NNNNDALKIASRMY-SRSY S--LDKNLSTTL-KDSYGVDI--------ESIDFDQ----PQM-VVKSA----------- ------------------------------------------------------------ -----------------------------------NRWIQN------------------- ------------------------------------------------------------ ----------ATNGVISR------------------------------------------ VISEKD---IKE----C------------------ANLILLNAIALNATWDGKYKL---T EQ-KLFRYLN-------GDQ---LTDFMTLEGR-FQHG-SVD----------GLRILNLP FQ-------------------KHPDLYMLLMVPE--SEAEPLTSLIDRL--DEKMYSAFD GALN--------FRKVILEI--PFFSVFTTVKGRDLLRS------------------LEL GDLFEDGAFNIS------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SEKSYEISEVIYCLLISGFEQ-----------FWRRT--------- -----------IIAQPVFVQIDRPFIFIVKNTASDE-----MLLLGHY---SYF------ -------------------------------------------------- >CqSRPN29 Cp:SRPN13 CPIJ007016 serine protease inhibitor, serpin supercont3.133 729426 731322 Cp_SRPN7 'SRPN-INHIB' ------------------------------------------------MFEIRVFREYSI F--------------------------------------------------RKVVVIEFN VGN---------------------------------------------LDFTLKFFRKH- -----YNSS----------SNSIVSPISV----------------RLALA------ALYQ AT--GPK-------LDPTFQQAISIP---TKNKKK--IADDIRAFL----E--------- -----------------------------------------TTNSEHLRVLFKAYKLDNA ---LDPTFEKTL-QDVFGTSI--------DTVDFRD----RVK-VTNVV----------- ------------------------------------------------------------ -----------------------------------NRWVSD------------------- ------------------------------------------------------------ ----------ATNQLIEK------------------------------------------ FVEESS---IDP----S------------------TEFMLINAVALEARWANKFTLNQ-T RQ-MTFHFEN-------GDR---EVQMMSQVMS-VSYK-IAE----------DFHAAELL YT-------------------EKSDLSMWIILPR--GR-GSLGDLVGSL--TPELLANIR LGAK--------TVSLNVEL--PRFTIRNEFDVNQVLEK------------------MGH GGLFGNADLQVF------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------AGSKSEIDDIFQSAVIKVDEEGTEASSGTVNVKWRVG--------- ---------------PRPFFANKPFIFFIQKRSTNT-----ILFIGQY---SNHED---- -------------------------------------------------- >AgSRPN7 Ag:8 Ag:N23232 7 ENSANGG00000018236 ENSANGP00000020725 ENSANGT00000020725 R/V 2L 28D agCP3300 Ag_7 ----------------------------------------MKLAAAGFVATAALLLVLCI TVAEGQGTTGTGTI-------------------------------------GTNGGPDLS FGD---------------------------------------------ADFSVQYFKQS- -----FNAS----------GNSVVSPLAV----------------RLAFS------ALYQ VT--DSG-------TREAVQRAFYLP----SAVSD--ARANAEQLV----SD-------- -----------------------------------------LEQSRFLNVSFALLQSEGQ ---LSQELEDAA-RAIFRVKP--------RTVVFAN----RRA-VVEDV----------- ------------------------------------------------------------ -----------------------------------NEWAVQ------------------- ------------------------------------------------------------ ----------VTGGRIRD------------------------------------------ YLAESD---IDV----N------------------AELMLLNALHMRADWAQKFAMEQ-T VG-QTFQFRN-------GPA---SVEMMSVALEVLYYA-----------Q-PKFHAVQLP YS-------------------EESDLTMWILLPH--RD-GTFEELFELL--SAELLDELE TSVA--------PKMVDLWL--PKFTIEDSHDARDVLKR------------------MGH ETLFDREGFAVF------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RDHKSMLGALKQSTFVQVDENGTEAAAVTSVGTKFRV--------- --------------RNTQFRVDRPFIFIIKKLSIDT-----ILFVGHY---SNHN----- -------------------------------------------------- >AaSRPN7 Aa:10 Aa:N36616 AAEL002699 7 Aa_7 -----------------------------------------------MLITRVIPLVWLI VVV------------------------------------------------AGGDGPDFS FGD---------------------------------------------VDFSVEYFKAA- -----YNAS----------SNCVVSPLSV----------------RLILA------AFYQ VA--SAD-------VEETLQRAFYLP----LEKSV--ASDNVAEFL----EG-------- -----------------------------------------VSGSSQLQIAFKALKNQDQ ---LSEVFATTL-QKVFKTTP--------DNVKFED----RTS-VANSI----------- ------------------------------------------------------------ -----------------------------------NRWASE------------------- ------------------------------------------------------------ ----------STNGRIQK------------------------------------------ FISEDD---LDT----N------------------SELMLLNAVALKASWAEKFSASK-T DP-QLFAFVN-------GPR---QVDMMHETLE-VLY--KID---------NTYHTIQIP YS-------------------EDSDLAMWILVPR--GS-GTFEGLLNAL--SSGLLDDIE TTAM--------PKVVDIAL--PRFKIRSNLDAKQVIER------------------MGY GVLFAENEFNVF------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EGRKSSLSDLRQSTFLTVDEEGTEAAAVSSATTKFRS--------- --------------KNIQFNVNQPFVFIIKKISTDT-----TVFIGHY---SIYQ----- -------------------------------------------------- >CqSRPN7 Cp:SRPN14 CPIJ007017 serine protease inhibitor, serpin supercont3.133 732578 733796 Cp_SRPN7 'SRPN-INHIB' -----------------------------------------------MLIKAVVPLVFVT IAVV-----------------------------------------------VGADGPDFS FGD---------------------------------------------ADFSVEYFKAA- -----FNAS----------RNEVVSPLSI----------------RLALA------AFYQ VA--GSV-------VEQTIQRAFYLP----LEKSV--ASENAAGFL----EE-------- -----------------------------------------VSTNQQLQVAFKVLKNQDL ---LSDEFASTL-SKVFKTAP--------ESVEFAD----KRS-VVTSV----------- ------------------------------------------------------------ -----------------------------------NTWANR------------------- ------------------------------------------------------------ ----------ATNGQIRN------------------------------------------ FLKEDE---LDT----N------------------TELILLNAVSLKASWAERFSEAK-T DR-QSFAFRN-------GIR---PVDMMHETVE-VLYK-VAP----------EYHAVQIP YN-------------------EESDLSMWILVPR--GQ-GNFDSLVASL--SSDLLDDIE TTAM--------PRAVDISL--PRFQIRSELPAKKIIEK------------------MGF EQLFAESDFSIF------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KNRKSELSDLRQSTFLQVNEEGTEAAVVSSATTKFRA--------- --------------KNAQFNANQPFVFIIKKISTDT-----IVFIGHY---SNFEQQQ-- -------------------------------------------------- >AaSRPN21 Aa:12 Aa:N36618 AAEL002730 ----------------------------------------------------MKLLSFFV ILSITN---------------------------------------------GFNIGATTP SEAS--------------------------------------------IQFSLSFFRAA- -----YNLN--------PNRNCVLSPIAI----------------QHTLA------MLHH AA--KRK-------ESSQMHRLLRIP----ESSDS--YFERNEPFS----N--------- -----------------------------------------DLNNDALEMITKVFHSQVE ---LNPNLLPVL-QAEYSVDV--------QVSDFSR----PEQ-VVDSV----------- ------------------------------------------------------------ -----------------------------------NRWASR------------------- ------------------------------------------------------------ ----------FTNGLVGD------------------------------------------ VFNGNG---FSD----D------------------ANLMIINTLTFNASWEHPFSPRS-L LK-DDFYFLN-------GVR---KVDTMRSYKG-FRYC-EID----------DIRAVELA YE-------------------RNSDLSMLIIKS---DS-QPLDTVIERF--DMEMYQTIN ERLY--------HDRFKLVI--PKFTISTGIGAKRILKA------------------MGL SDVFGKDTFDVF------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VGFSSRLANIYQAVRIDIDENGTRAAAGTYSEKSMRV--------- -------------GTDFKYAIDGPFMFVIRKDTTKD-----IVFIGHY---SSYVE---- -------------------------------------------------- >CqSRPN34 Cp:SRPN1 CPIJ000214 serpin B10 supercont3.3 1965484 1966706 Cp_TBC 'SRPN-INHIB' -------------------------------------------------MWSNVVVTLVL FCGG-----------------------------------------------IAAVASSSD GGGS--------------------------------------------VRFAVDFFKHA- -----YTAR----------QNAILAPIAI----------------RSGLA------MMHH VA--TPD-------AARILRDGLYLP----ADGLG--VIEQTKWVM----SCV------- -----------------------------------------NERKRMLEMLSRVYLPDAL ---LNPELVAHL-RDNFGTGS--------EIVNFAE----GSE-VAERV----------- ------------------------------------------------------------ -----------------------------------NSWVNE------------------- ------------------------------------------------------------ ----------SSRGMIPE------------------------------------------ FLKADE---LSG----D------------------VISLLINVMVMNASWGF-FDEKK-T KK-QTFHFLN-------GDH---EVDMMKVDGT-LPRM-YLE-------D-LMTDAIKLS YG-------------------WRSDLSMVILLPR--KE-VNLEHVIKHF--TADHYNQLV QLDNE----DKWYGNIRLGV--PRFKIEQKLDAKATLEK------------------MGL GELFDQEAFQVL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------ATRLSKLGQVKQSAFIKVDEKGTQAAAAAAIQSYLIS--------- --------------GSWDVDVDRPFMYIVRKESTKD-----ILFIGHY---SNYEG---- -------------------------------------------------- >AaSRPN20 Aa:11 Aa:N36612 AAEL002720 -------------------------------------------------MKWVLFFAFLV IER------------------------------------------------ISAELSEYT TST---------------------------------------------TSFTCDFFKQV- -----YNPA----------ENVVISPVSI----------------QTSLS------MFYP FA--GSK-------VAPVMQQCLYLP----ADKNH--ATTNLRSFL----QSLNAKT--- -----------------------------------------TAGTSTFKMLSKVYHVDAN ---LKPQVAPLF-KETFGAEI--------DVADFHD----QAK-VAAEV----------- ------------------------------------------------------------ -----------------------------------NSWVNQ------------------- ------------------------------------------------------------ ----------ATNGMIKD------------------------------------------ FMQADD---VRV----D------------------NDLMLLNVVALNASWEVPFNAAD-T ES-MTFHFVN-------GDH---PVDMMFKQEQ-VLYA-NLP-------D-HGCQAVELL YE-------------------EGTDLSMVIVLPM--KK-SSLENVVRDM--GVALYEKIN ERLS--------LERVQLAM--PKFTMQKKIDAQELLKN------------------MGL TALFEELDLDLL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------ERDKSRIGEIRQMTFIKVDERGTEGAAATETQAVGRA--------- --------------GYPNFYVDRPFLYLIRKRSTKN-----IIFIGHY---SAYEQ---- -------------------------------------------------- >CqSRPN20 Cp:SRPN15 CPIJ007019 serine proteinase inhibitor supercont3.133 743708 745897 Cp_SRPN20 'SRPN-INHIB' ------------------------------------------------------------ ---------------------------------------------------MIPILAEFT ASS---------------------------------------------TDFTFRFLQRA- -----YTPT----------ENAILSPVSI----------------QSSLA------MFYP LA--GPA-------VSPDMQRHLNLP----ADKTI--ATDNLRRFF----ASISKQ---- -----------------------------------------QARPDALKVLSKVYHVDAE ---LNPEVLPLF-QGQFGAEV--------ETANFQD----QET-VVRSV----------- ------------------------------------------------------------ -----------------------------------NEWVDR------------------- ------------------------------------------------------------ ----------STGGLIPN------------------------------------------ YMEPGE---LRV----D------------------TDLMLLNVVALNASWQDPFDPEE-T EE-SDFQFLN-------GVR---KVQMMHVAGE-FQFG-VVN-------E-HNCYAVELN YE-------------------EDTDLSMVLILPK--KK-HTLQDIIQGL--SLDLYRALD ESLH--------KVRVAVAI--PKFTMPKKLDAKELLMN------------------MGL KSIFENLDFDLL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------TKYKSKIGEVRQTGFIRVDEKGTEAAAATVQAVGRSS--------- ---------------IPTFYANRPFLYLIRKRSTKD-----IIFIGHY---SVFEEQQ-- -------------------------------------------------- >CqSRPN30 Cp:SRPN29 CPIJ010576 endopin-1 supercont3.268 208664 209945 Cp_SRPN7 'SRPN-INHIB' ----------------------------------------------------MLTFAFIL LLFGTS---------------------------------------------QARGKSDES YGWDFVQRQS--------------------------------------TNFSLNFYRHS- -----FNPD----------ENAIQSPVSV----------------QATLS------LLYH VA--SNS-------TAADMQAILGLP----AAKKK--PIPSLVEFL----NST------- -----------------------------------------GGSDSVLRMVAKVYHSPED ---LNTKFLPLL-QDSYKVEV--------EEADFKQ----KQK-VVDSV----------- ------------------------------------------------------------ -----------------------------------NRWVNS------------------- ------------------------------------------------------------ ----------STNGLIPD------------------------------------------ LITASD---LKD----N------------------DRLILLNAITLDAKWEHPFPKSS-A R--KTFHFVD-------GDH---DVDIMSMDEE-VSCG-NLG----------DLNLLELP YE-------------------SETDLSMLFVMP---KN-GSLQDLVNQL--TLEFYERLN SALK--------LEYGTVEI--PKFSIQSKVKAKDVLQS------------------MGL GSAFEVKAFKVF------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------ARKPAQLSELRQKAVINVFETGTTAAAVTEGQLAFHT--------- -------------IPLELFIGNRPFIYLIRRTSTKE-----IFFIGHY---SHYKQ---- -------------------------------------------------- >CqSRPN31 Cp:SRPN18 CPIJ007023 serine protease inhibitor supercont3.133 758924 759336 Cp_TBC 'SRPN-INHIB' -------------------------------------------MVNLKQSIGRIFLVASL LMPQVFG--------------------------------------------LAIERYDFT EQS---------------------------------------------TKFAIDFYRNV- -----FNTN----------ENAILSPLSI----------------QSTLS------LLYH VA--NAK-------TASKMQRILGLP----ANPEQ--LRLNLQNLL----N--------- -----------------------------------------RTNSDDLRMASKIYHSQLS ---LHPDFLPVL-QKSLGVDV--------EPANFTH----KQE-VADSV----------- ------------------------------------------------------------ -----------------------------------NQWAAR------------------- ------------------------------------------------------------ ----------STKGLINE------------------------------------------ IISPID---IRD----S------------------EHVILLNAIVLDAKWKEPFWPF--T IE-KVFHFTN-------GDH---IVGMMFMDGY-FSYG-EFD----------GLKALELP YE-------------------DHTDLSMVLILP---TT-GSLEDLVKRF--NMELYTKMD SVMD--------VEKGEIEI--PKFKTSSKIKAKDVLQS------------------MGL ESAFEEGAFRVF------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------AEHPAQLTELRQNAVIEVSESGTKAAAITVGGIDLRS--------- -------------GPLYDFIADRPFMYLIRRMSTKE-----IIFIGHF---SHFK----- -------------------------------------------------- >CqSRPN32 Cp:SRPN19 CPIJ007024 serine protease inhibitor supercont3.133 760774 763802 Cp_SRPN22 'SRPN-INHIB' -------------------------------------------MKVSVRSNRVLACVVLF ACAATHIQG------------------------------------------YAIEGQDFA TRS---------------------------------------------TKFTLDFFRKS- -----FNAN----------ENTVMSPISV----------------QSTLA------LLYH VA--SEN-------AATDMQRILELP----PTADQ--LIPDLRRFL----G--------- -----------------------------------------RTNNNVLKMVSKVYHSQEE ---LNPEFLPVL-QEALDVQV--------ESTDFTQ----KQQ-VADSV----------- ------------------------------------------------------------ -----------------------------------NQWVDH------------------- ------------------------------------------------------------ ----------STNGMITD------------------------------------------ LINPDD---IRD----D------------------EQVILLTAITLNARWEIPFMTVPWK ---RTFHFVN-------GDR---EIDMMTEMDD-YSYA-EVD----------NLKVLEIP YE-------------------EHTDLSMVMIMP---TK-ESLEDLMKRF--NMKLYKKLN SAMR--------VTKGNIEI--PKFTINSKIPAKDIMEK------------------MGL GSVFGVDAFDVF------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VKKGAQLSELRQRAVINVFEGGTTAAAVTEGRIVLLS--------- -------------GPSYEFIADRPFVYLIRRQSTEE-----IFFIGHF---SHHE----- -------------------------------------------------- >AaSRPN22 Aa:13 Aa:N36628 AAEL002715 ----------------------------------------------------MIIIYFLA YYT--------------------------------------------------------- ------------------------------------------------DDILIEFQAS-- -----FDER----------RNLATSPFSV----------------QLGMT------MLAN SV-TDGY-------TLKQMTEKLHLP----SSIARASEQNRRKLMV-------------- -----------------------------------------LQKDKHFTYGTKLVVFGTE A--LDPKFLATM--SNFNTPA--------ERHSIAN----IKS-IPTLA----------- ------------------------------------------------------------ -----------------------------------NRWAKN------------------- ------------------------------------------------------------ ----------VTSGMVSA------------------------------------------ VLMNNE---LLP----D------------------TRMILLSATAFACQWENKFSVNS-S KM-EMFNAYT-------TGKLY-MTNFMNLDQTLFPVAMNGE---------LKMQAIELP FE-------------------RGSDYSFMMMMPL--DRDGNVTDMVAKL--DHQTFAKLY DSLV--------PTRISVKM--PRFTVSTSVNGNAVLKK------------------LHL NAPFQWSRFQIF------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KQEKLTLDKVKQSVTVQVDERGVRAAAVDKFTMVTRS--------- --------------APLSFLADRPFVFAILKKSVHF-----PLFVGHY---AYPAQASPV KP------------------------------------------------ >CqSRPN22 Cp:SRPN20 CPIJ007024 serine protease inhibitor supercont3.133 760774 763802 Cp_TBC 'SRPN-INHIB' ---------------------------------------------------MLLFQALFL FAAFA----------------------------------------------SSTTQQDLF T-----------------------------------------------TDFVWDVVKQT- -----SFHE---------RQNMVLSPFVI----------------RAGMT------MMAS SV--NSHF------TMQKLSQKLRLQ---GVSMAA--VLEQFRRRL----QL-------- -----------------------------------------LAMDRDVRIGTKVYVYGTS D--LNPNFAAGV--RYFNAGV-----EKRAQLEVGQ--------LAREA----------- ------------------------------------------------------------ -----------------------------------NDWANW------------------- ------------------------------------------------------------ ----------TTSGMVTR------------------------------------------ VVKSSD---IRD----N------------------TRLVLLNAITFRSEWQHRFELKN-T RK-ELFYSTG------TGQPF--MTDMMNLRSIELPYGYYEP---------LNALSIELP FK-------------------TGSDYSLVVIIPV--DKSGNLTQLVQNL--DHETFKKIQ NSRI--------KQSVHVKL--PRIKLTAEVNVNDVFRK------------------LHL TAPFEWSVFQVF------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KDEKLALDKAMQSVSVEIDERGARAAAVSMSFTSRSA--------- ---------------TPTFYADHPFLYAIVKKSQQY-----PLFVGIF---AFPINKSL- -------------------------------------------------- >DmSpn28D Dm:3 Dm:N11334 CG7219 6-like Dm_Spn28D --------------------------------------------MWRLLLALLLVSSVCC ESELFRDDLRTPETMAYINGLMQRRHQMQQEAQQHIQAIPPAVPLQSPGLVNGLGNQNDP ALNRISGTSVKPSNLPAAYSNGYVD-----------------------LATSDRIANSV- -----LNFANILGQHLANGKTQIYSPLSI----------------VHSLA------LLLL GA--KGR-------SYEELSTVFDIP-----DTSR--LHEQFGLML----QDLQQPTREA ISAGRPLTDWRASSAMRSNRRAQ------------------RPGAHEVHLANGLFTQTGY T--LNPDYRRVI-VEVYASDL--------QIQDFEG---SPAT-ARYNI----------- ------------------------------------------------------------ -----------------------------------NAYVAQ------------------- ------------------------------------------------------------ ----------HTKNHIEN------------------------------------------ IIASDI---PQT-----------------------TRMILANALYFKAFWETDFIESA-T RP-DNFYPNG------EGTEPVMRVQMMATGGA-YPYH-EDH-------E-LGCKIIGLP YR--------------------GNLSTMYIIQPFKSSV-RELMALQKRL--TADKIESMI SRMY--------RRAALVAF--PKMHLTESVNLKTVMQR------------------MGL GGIFSAVQNDLSLIATNEATRTNALGGNSLQNLEAQRRAGTGG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------ARSDLVVDDIVHKVDFTVNEQGTEAAASSVTYLKKSG--------- --------------PDVLFRGDTPFMVLVRHDPTKL-----VLFYGLI---NEPPAAA-- -------------------------------------------------- >AgSRPN6 Ag:7 Ag:N17014 6 ENSANGG00000008056 ENSANGP00000010545 ENSANGT00000010545 I/G 3R33C agCP4562 Ag_6 ----------------------------------------------MKHLQMLPIALCVL LVPIVHGQWNRYYTQAPQTRYTPMVRTAQRVALRHSFETDGTPAPSTVRPRPPAPPTNAP SQLPALTPDNDAKISQLV------------------------------VDFMMRISRTL- -----PQQQ---------SRTELFSPLSI----------------ITVAN------LLFL GS--GGS-------THEEFGKVLTPS---SMNWKR--MHQRYGNVL----ANLMSPEPID SRRDQWRRQTCPRDDDYEDGEGGP-----------------AAKSQVIRVANGIFYQKDL P--MRQQYVMLA-RSLYGALI--------QPIDPQA----SAA-STALI----------- ------------------------------------------------------------ -----------------------------------NRWVSD------------------- ------------------------------------------------------------ ----------VTAGKIRN------------------------------------------ MLEGP----LSP----S------------------SSVVIANALYFKAKWKTQFEPLV-T RD-APFFPDG-----LDGPSY--RVKMMSMSGC-LPFY-RVR-------DTLDTTIVGLP YR--------------------DDTSTMYLIQPANSSR-TAIRRLQATL--TGKMLDSWI SQMK--------LQSTMVRL--PKMHLRNSVDLLQSFQK------------------LGF NSILSPAKSDLSNMIDSSSS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------AGPKPYVNQILHKLDLTIDEEGTEGAAATSALVDRIG--------- --------------SQRQFNGNAPFLIYLRHDATGL-----PLFYGPI---FDPR----- -------------------------------------------------- >AaSRPN6 Aa:9 Aa:N32194 AAEL010769 6 Aa_6 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MQRFSQFAL----------------NKSIV------VAFY IH--NTQ------------------------------HTRYIRKIH-------------- ----------------------------------------------ILRLANAIFAQDNL V--LSPKFVQAA-GDIYGASS--------QQVNFRN----GAA-AASTI----------- ------------------------------------------------------------ -----------------------------------NNWVNK------------------- ------------------------------------------------------------ ----------ATSGKIRE------------------------------------------ IVSGSF---SSE-----------------------TSVVIASSLYFKASWQNEFIPKI-T KP-KDFFPDG-------KGRPSVKVDMMSLIEC-LPYHFEQS---------MGFKMIGLP YS--------------------DNSSTMYVMMPQDSTR-AKVRDLQSRL--TAAKIDSMI PMMK--------RRTATVSF--PRMQLESSTNLQKAFRQ------------------LGI KSIFSAQNSNLRNMVVPKAQ---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GQQNLFVSQINHKVNLSVDEKGTEGAAVTMTLIDRSA--------- --------------SAVYFNVNQPFLIYVRHDPTRL-----PLFYGAV---FDPRG---- -------------------------------------------------- >CqSRPN6 Cp:SRPN34 CPIJ012013 serine protease inhibitor, serpin supercont3.346 385437 397533 Cp_SRPN6 'SRPN' ---------------------------------------MAWFILPAQSQNPQATFTYLL RRSTTPSPRRLAKTSTGRLSSRSSA--------------------------LTNPTALTP ASNDAQLSAAV-------------------------------------ADLAFAIGQHS- -----NDLD---------VAADIFSPVSI----------------MAVLN------LLLL GA--EGT-------TYRELLGALRLGNVPMKEYHR--RAAGMTRNL-VAEKSLELDQLAW KGKNCVVYEYEDDEEEEEVQPV-------------------KSKTKELRIANAIFTQKQL P--INAKFVSLA-NQLYGAST--------QAVNFLD----SLS-TTSLI----------- ------------------------------------------------------------ -----------------------------------NKWVSQ------------------- ------------------------------------------------------------ ----------ATNGRIRE------------------------------------------ -VTNGQ---FSP----E------------------TNMVIASSLYFKATWMTEFTAYA-T RP-RDFFPDG---SSRGGAAF--KVDMMSLTEC-LPFYSDKA---------SGIKMVGLP YS--------------------DNATTMYVLMPKDSSR-AKIRNLQKQL--SAKQLDSMI SGMT--------RRTTTVNF--PRMQLASSTNLEKSFRR------------------LGI KTLFNAQQSNLNGMLDQSAR---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------NKIPLFVSQINHKVNLSVDEHGTEGAAVTVTLVDRSA--------- --------------SQAYLNANEPFLIYVRHDPTRL-----PLFYGAV---FDPRG---- -------------------------------------------------- >AaSRPN4a Aa:5 Aa:N44314 AAEL013936 4-like -------------------------------------------------MRFLAPLGIVL LAIVSHC--------------------------------------------QGQGFDPTV GATPENLAAVSQSV----------------------------------TNLAQKISLAI- -----ANPK---------SKTEIFSPVSI----------------AGALS------LLLL GS--GGN-------TRDELMNVMGFQ-HSRLTFTD--IHKSFGRLF----QDL------- -------------------------------------------GSHFISVANGVFVDNSL P--LNPRYAKLT-KELYGGEI--------APMALYS-D--PVR-SSNFI----------- ------------------------------------------------------------ -----------------------------------NSWVQE------------------- ------------------------------------------------------------ ----------ATRNKIQR------------------------------------------ IVSPEQ---VSN-----------------------APMVLVSALYFKAKWETMFIEQD-T RL-RQFYPYG-------PNAAPVDVESMATNGC-FPFY-EDK-------Q-LDAKIAGLP YQ--------------------EGKSTMYIILPNESNP-QKLRDLQTRT--TLQYWDDII DQMV--------VKTGTIIL--PKMKIENSLGLRDVLAS------------------LGL RDVFIPERSNLNAITKDDPILNDMNRRPAASQPARPQNPVRQPSTTPPNTNTSPGWTPPI RNEQKVPMPLNSSECEMCNNCLYEADQCICNPNQQIDEQSGCYRKPMTVKYSCVAEKILY SVRFSSILHVCLVEGYDKTQQCTRSCRKFRDECFCCRGAAQTVSNQRPSTGSQTTQQPEI QSGYQPVQQQGTSNQPTESPLTSGDDIGTRFNSYEPPNTTPLVGRCQTIRECNSWGRCRY STYCALVNSPKRSKRQAVNS---------------------------------------- --------------QPAKLFVGDVLHKVSLDVNEQGTEGGAVTAVVVDRIS--------- --------------SSFNLRVNGPFLIYLRNEVTKV-----PLFYGAI---FDPRP---- -------------------------------------------------- >CqSRPN4a Cp:SRPN24 CPIJ009132 serine protease inhibitor, serpin supercont3.220 82627 99139 Cp_SRPN4A 'SRPN-INHIB' -------------------------------------------------MRLKFVLGAVL VLVLHEATS------------------------------------------QGQFEPSNT DNLDVVANSV--------------------------------------TNLAQKISRAI- -----ASQK---------SKTEIFSPVSI----------------AGALS------LLLL GS--SGV-------TRDELTKLMGFD-NQQISFAD--IHKSFGKLF-------------- -----------------------------------------GELSHQISVANGVFVDRNF L--LGARYEQLT-RCLYQGKA--------QRLPFST----DPRSTAQQI----------- ------------------------------------------------------------ -----------------------------------NSWARE------------------- ------------------------------------------------------------ ----------STNGKIRE------------------------------------------ IVTPEQ---VQN-----------------------SPMVLASALYFKGKWETMFVEPD-T RP-RPFYVNG-------RNQPPVNVTAMATSGC-FPYI-DVK-------D-WDAKIVGLP YQ--------------------QGLSTMYLVVPNSSDR-QKLSFLLGNTI-NIEQLNNMI DRME--------VKTGAVVM--PKMQLENNLGLKQVLSS------------------LGI STLFDPYRSNLSVITNTAFDQDGDIAKSCNVNRRPEEPTRRRIPTTTSRPDFVFRLGTNS SDNQEPVQSAQQNQPPRNVFQQSNEVIVPVAESRDCFFIRNCVYENNLCKCILDPESAQD QEICPQRPFYAVQNCDDKVMSSDGWTVCHSKQYRNTKTTNMKVCLSSACSYFNGACYCCD APKRTTLPPNQQHFPQSQITQQQQQSFDVASRFGAGPSVQQPQQSTINDNDRRQGSFNNQ NNFQQLAPPPAPQVPAPPSYDQNLPPQAIVSCFEQQECFYLQGCRIIRKCYQNTNKVAQS LMNLSGRNRSKRQTNQRPLFVGDIVHKVSLDIDESGTEGGAVTAVVIDRIS--------- --------------SSFTLRLDGPFLIYLRHDATKL-----PLFYGPV---YDPRD---- -------------------------------------------------- >AgSRPN16 Ag:15 Ag:N16933 16 ENSANGG00000024665 ENSANGP00000029229 ENSANGT00000025969 A/L 3R33C TCLAG039304 NOT NAMED IN ENSEMBL Ag_16 -----------------------------------------MGIRRDESVARLLLLLGCV ALHTSAALAQSQQTFRSQPQ-------------------------------YGNRGSSFA APALTQAAPAPVVSQPPATRDTFRYNPA--------------------SAAVTELARLI- -----GSIL------GQQSKAAVFSPVSI----------------ACALS------LMLL GA--EAK-------TKDELIQVLGFE-QYRNHLHN--IHQLYSDML----KDLARTEFDR RPPHWRTSNPCYDDDDEEDAAAAAAEF--------------PLQKDVIRVTNAVFVQEGF P--LNGGFTYYS-NRYYSSNA--------TNVPFAA-N--PAK-AVALI----------- ------------------------------------------------------------ -----------------------------------NAWAAR------------------- ------------------------------------------------------------ ----------STEGRIRD------------------------------------------ IVSESV---AAD-----------------------AEMIVASALYFKGLWSEPFEPQA-T EL-KPFYPDG-------YGRELKLIPSMSTVGC-YPYY-DSP-------E-LDAKIVGLS YQ--------------------GNKSALYIIQPNNSTR-QRMQEFQRRL--TPAMIGELV SKMT--------QRKMYLQL--PKMQITNTINLRDVLQR------------------LGL HTIFNRGQSDLSGMVAVPPLSVEQFATRFGLADTERPADPTAVIFPHEDHYSQPQLQQPS TDTRRGTSNSNNINAATGQQQEPARG---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------TGPQLHVSEFIHRVELEINEKGTEGGAITSSTIFRAL--------- --------------PSINLRIDAPFLLLVGHDETRL-----PLFYGTI---YDPTP---- -------------------------------------------------- >AaSRPN16 Aa:20 Aa:N14740 AAEL014138 16 Aa_16 --------------------------------------------MITRYSHVVTVVVIAL ASHLVNAQNRAGWVQNPPENAVYLQQQSQQPTV------------------SQSRPIYFP QGQTINPARVSTAPPPPAPSFSQGQTK---------------------FQYDAASFAVT- -----ELARQVGAVLGQQSNAGVFSPVSI----------------ACALS------LLLL GA--RDE-------TRRELMQVLNFN---PNDQDPNGIHRQYGRLL----QEIASTAPDA IPVAWRRNDRCSDEDDDDY----------------------KQESQITHLANAVFVQKDL K--IDNSFIHWS-RAFYNSSI--------KNLDFAN----NPQKSAFQI----------- ------------------------------------------------------------ -----------------------------------NRWAHE------------------- ------------------------------------------------------------ ----------NTFGKISQ------------------------------------------ -IVPNS---VNP----D------------------TQMIVANALYFKGLWKEVFEKQA-T GY-KKFYPDG-----HANPSTAKDVLTMAAIGC-FPYF-DSP-------Q-YDARIVGLP YQ--------------------GDKTALYIIIPNNSSR-QRMQQFQQRL--TAKDIGAMV SQMT--------VRKALVQI--PKMKISNTINLRDVLQK------------------LRL RTIFSPSTSNLSAMLDNSS----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GHERLYASEIIHKVELDVNEVGTEGGAITASTIFRSL--------- --------------PSVQIRVDTPFLMLVGHDATRL-----PLFYGSI---YDPTG---- -------------------------------------------------- >CqSRPN16 Cp:SRPN35 CPIJ012016 serine protease inhibitor, serpin supercont3.346 430056 432828 Cp_SRPN16 'SRPN' -----------------------------------MSSRSAGRVEQRARLRAGFPQQWIR QNPPPQVVV------------------------------------------AATNWFKLP YDTFWTCF----------------------------------------PKYPKIILTPIL HLENEGFPSISPKVPQFQNVGQRQYPQQF----------------RPGQP------LVQS NN--RATPPPQQQQSGQGQAPQFQYD---TASFAVTELARRMEPYW----AS-------- -----------------------------------------RARRGLIHLANALFVKDGL Q--VNPTFVDAS-KGFYNTSI--------NLMDFSG----NPQQSANYI----------- ------------------------------------------------------------ -----------------------------------NQWASD------------------- ------------------------------------------------------------ ----------NTYGKINQ------------------------------------------ IVSNY----ISP----E------------------TQMIVANALYFKGLWKEMFEKQA-T TF-RKFYPDG-----HANPSTAKEIPTMAVIGC-YPYY-DSV-------E-HDAKIVGLP YQ--------------------GDKTALYIMIPNNSSR-SRLQHFQRNL--NAQKIGQMV AQMT--------VRKALVQI--PKMKISNTINLRDVLQK------------------LNL HSLFNPATSDLSKMLKPFGPNPDTYYPDRVVFSDSQKQFQQQ------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SQQRLYASEIIHKVELEINEKGTEGGAVTASTIFRSL--------- --------------PSVQMRIDTPFLMMIGHDNTRL-----PLFYGSI---YDPSG---- -------------------------------------------------- >AgSRPN4b Ag:4 Ag:N16614 ENSANGG00000003652 ENSANGP00000004662 ENSANGT00000004662 I/S 3R35B EBI4662 Ag_4 ----------------------------------------MRSHYSAGWTLALVLLVSSL LAVSAANNRGQPAKPEAAD--------------------------------QQANRLHAP TANTKKVSDSV-------------------------------------TNLAAKIANAL- -----SNQK---------SKTEIFSPVSI----------------AGALS------LLLL GS--GGQ-------TQQELLAVMGLN-TVQLSFQD--IHLSFGRLF----QDLVSNDPSL EPLVTWRLNDKCNRYNEDEEDEEDDFINSQSPSNDQQPTKRDRKAHEITLANGIFVQRNI P--LSDTYRNQS-MTYYSSEV--------QSLDFEL---DTSG-STRLI----------- ------------------------------------------------------------ -----------------------------------NQWVSD------------------- ------------------------------------------------------------ ----------KTHGKIPN------------------------------------------ -ILPSA---LPA----S------------------TTMVLASALYFKALWAESFIDGA-T KP-REFYPDG-------KGQPPVMVDMMAHGGC-FPYY-ESV-------E-LDARIIGIP YK--------------------HNVSTMYVIMPNNSNR-AKLQQLIPKL--TSAVVKDLI ENMA--------IKTSIILF--PKMHISNTMDLKRVLQQ------------------LGV SSLFQAERSNLSPMLNEESQPDTFINRVQAPTTPAKWRPTVNIADYENRPTSTRPGDNLN DVLIFSRFQNETMDQTTDVPEAADTTEPLTIETTSQSFVPL------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------TNRPSGRVGRTKRDVSYKVPSSKQAAQAVGPLSSKDFILHKRIVKENGPVGKK GLRRRSKR------AAQQLYVSNAVHQVDLDVNETGTEGGAATIVTLNRSG--------- --------------TSVVFRAEAPFLLLIRNDQTNL-----PLFYGPV---YHPSS---- -------------------------------------------------- >AgSRPN5 Ag:6 Ag:N16937 5 ENSANGG00000008018 ENSANGP00000010507 ENSANGT00000010507 S/L 3R33C TCLAG045142 agCP4923 Ag_5 --------------------------------------MPYRALASVRKVPFRLLLPLGL LLCVCGGA-------------------------------------------LAEPAAQNT SGLSKAVSEQL-------------------------------------VGAINDLARTL- -----GVMAGRGGSSSNSSKTELFSPVSI----------------GSMML------LLLR AA--NRD-------TRHELLGVLRLEQYRKPGSGN--IPKNYARLLKEFTRDIGGKGILK QLPGWHAGGNCYPPSEGLEDEEYDDDQYLEE----------PIEPNVVQLANGMFLQQGL I--NSSNFVRLA-RDLYQAQI--------EQVNFKE-R--PDL-ARNTI----------- ------------------------------------------------------------ -----------------------------------NRWVNE------------------- ------------------------------------------------------------ ----------STRGRIGE------------------------------------------ ILLDDP---DPG-----------------------TQMIVANALYFRGTWETFFNEPQFT RP-QPFFPDG-------EDQPSILVPTMFASGC-FPYY-SSP-------E-LQARIMAFP YR--------------------NRTTSMYIVLPNDSNR-ARLRQLQASL--SSAELDRLI GQMK--------MHKAIVQF--PRMHASNTYDLKAALQQ------------------LGV RKLFDRTSNNLKIVSGKSSANGAEAR---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------AKVKLYVSEMVHKIDLEINERGTEGGAVTITAMERSL--------- --------------PPVNFRVRGPFLIAIRHDPTKM-----LLFYGAV---FDPS----- -------------------------------------------------- >AaSRPN5 Aa:8 Aa:N47629 AAEL014141 5 Aa_5 -----------------------------------------------MHITMNHPLGWLM IATVALLIIHQSSA-------------------------------------YTSKYVTKE IAQDLSKGF---------------------------------------NDLARDLAVQI- -----QSDT---------SKAEITSPLSI----------------ASSLL------LLMR TA--RGE-------SRADLLRLFGLESKYPENDPK--IPRTFGKLI----NELLIDDRNR TSIMENSAAWINESKCEIPTDYHYDDDYDQFNPLDDIPED-PLQQNQIKLANAIFVQDKF Y--NNTRLQKLV-NYYYRSSV--------EGLDFFN-Q--PEA-SKDHI----------- ------------------------------------------------------------ -----------------------------------NNWAKK------------------- ------------------------------------------------------------ ----------NTNGRIQE------------------------------------------ IITDE----LNP----E------------------TTMIVANALYFKAFWEDVFLAGA-T KM-RKFFPNG-------ENEESVEAEIMAHGGC-FPYY-RSQ-------E-LDARIMGFP YK--------------------NRTSTMYIILPNNSSR-AKVQQLLQDL--DASTLDNLI SNMR--------MTTASVLF--PKMHLTGTFDLKIALLK------------------LGM KSIFDSERSNFSLLNPSH------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PKESATVSGVLHKVDLAIDESGTEGAAVTATLLDRSM--------- --------------PTVNFRVIVPFILAIRHDATKL-----LLFYGPV---YDPSV---- -------------------------------------------------- >CqSRPN5 Cp:SRPN23 CPIJ009131 serpin B4 supercont3.220 65890 67345 Cp_SRPN5 'SRPN-INHIB' ----------------------------------------------MLFLRKLVIVTIVV AVALTEAQHKGR---------------------------------------PYETRSKFV TKDAARDVSDAL------------------------------------VNLARNISVQI- -----RSKE---------SKSEIISPLSI----------------GSSML------LLLR AS--RGS-------TRQELLRLLGLE---KYKRNDPKVPRNFGQLIEELLDDVRSKNVLE SEPQWKEESKCISPEYADDDDEYEEYDDIDGAS--------EQDVNIIRLANAIFVQNGT Y--DNEKLEVRV-RRIYRSKI--------DNVDFFN----SPDESKAVI----------- ------------------------------------------------------------ -----------------------------------NQWVDQ------------------- ------------------------------------------------------------ ----------NTNGRIKE------------------------------------------ IITDQL---SRD-----------------------TTMVVANAMYFKAFWEDVFTAGA-T KP-RKFFPNG-------ESEESVEVDMMSHGGC-FPYY-ASK-------E-LDARILGFP YK--------------------NKTTAMYIILPNKSNR-KILQDLVGKL--DANTLDELI SNTT--------MRTASVLF--PKMHITNSFELKSALRM------------------LGL SSMFIQGRSNFSLLNTNMT----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SANSPTVGGVLHKVDLEVNEEGTEGGAVTATLMDRSL--------- --------------PSINFRVITPFVLAIRHDATKL-----LLFYGSV---YDPSSE--- -------------------------------------------------- >DmSpn43Ad Dm:22 Dm:N5472 CG1859 Spn43Ad Dm_Spn43Ad --------------------------------------------MIHWRLLSALLVGLAI ALTLPV---------------------------------------------DGELLARSP ASVSS-------------------------------------------NRFGLRLTTKL- -----GLTQ--------PDANVVVSPLLI----------------QAALS------LLYA ES--SSE-------YGSQLRQALELT----HASHPKLAVQDFETLL----TDLKQS---- -----------------------------------------AAIGCRLRLLSDLYAQQRF TFNFRNEFETLA--ARMGVGC--------HRLSWES----ASN-AAQDI----------- ------------------------------------------------------------ -----------------------------------NYAFLS------------------- ------------------------------------------------------------ ----------RSNFSLGE------------------------------------------ LVSAPQ---LESLAEHN------------------TPFLHVSGVTFRAPWAWAFDPTE-T QS-INFFAGG-------NRPR--LVDAMFGQHR-YRYA-EVP-------A-LDAQLIEVP FA--------------------TADLRMLIVFPN--RP-DGLAQLERKL--AQSDLHQLR SQLE--------ERKVALTL--PKLRVLVHSDLKHVLEE------------------LGL AKLF-TSEVHLSEVFSSIL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SSSAPPLGAVVQSGLLELQEDGGNADDSFSFGDLFRR--------- ---------------ALPLVINHPFFYAIGNGKTLL-------LSGHI---VDI------ -------------------------------------------------- >DmSpn31A Dm:24 Dm:N9471 CG4804 Dm_Spn31A ------------------------------------------------------------ ---------------------------------------------------MSEAANPTP YD----------------------------------------------CHIGAGIYHSI- -----ATSF--------AEQNVVVSPLLL----------------EATLS------LLFL GS--DGA-------TAEELQKQLRLKQRFASNAK---MANFYAAEL----GNIT------ -----------------------------------------TDADTFLQLQNRLMLSSES G--VADDFQKIA-QTYFHATA--------ECVDLEQ----TEK-LRRHI----------- ------------------------------------------------------------ ----------------------------------SEQILAS------------------- ------------------------------------------------------------ ----------VGGGSWKD------------------------------------------ IHVAGG---SSA-----------------------NTLLLLLAANLQSKWFLPFSAYR-T GL-YEFHSGS-------QVK---SVPMLFDDDMFVKFA-ELR-------D-LDARAIELP YE-------------------HAEELSMLLILPN--QR-GGLQELEKQL--HDLDLGALQ QRMQ--------MEGVQVLL--PKFSIDFECSLRQPLKQ------------------LGF EEIF-AASANFKHLH--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------ASANLPIADVLQKLRINLNESGSGSGPELPKNATEYK--------- --PIVI----SNSSRQKFFRADHPFFFAIRSENVTY-------LMGHV---VEF------ -------------------------------------------------- >AgSRPN11 Ag:17 11 ENSANGG00000014319 ENSANGP00000016808 ENSANGT00000016808 2R8A TCLAG019800 agCP12201 Ag_11 MIWILLVVALATHGSCQRFKGSTFTTKDDYCFLNGIRQSECDYQFATFLDANPHFVKCIA SLPIYSDRCATINSALQPSKEPAPCNGNRCTYDTRLSGAGSVASTSMDRQPAGDAGLEVP KPSVRYDKKV--------------------------------------MDFAVKLFQKA- -----FPSD--------DTSNYIISPIMV----------------QSLLS------YLFD GA--SNA-------TRLEMESVLQLN---MNDLHD--IERALTPQA----DQE------- -----------------------------------------PITKNKLDSASQIFKSTTF E--LLPAFRDSL-KSNHVPLS---------EMDFSN----PRL-ASETI----------- ------------------------------------------------------------ -----------------------------------NNWARE------------------- ------------------------------------------------------------ ----------KTRQRIQE------------------------------------------ VVDEKS---IDP----Q------------------TKLFLMNALYFNGTWLNKFPK---T ER-GAFYVSG-------QPPVRSSVNMMFLTKE-LRNG-NTR----TDDSAHGMTWIELP YD--------------------GDRMSMILFLPN--EQ-FQLDRELRRF--TAQDLLTIL TEIE-----QDEPSKVKLQL--PEFKAETTVSLVEPLKK------------------LGV ASIF-GDNKPFDQL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SNDNVKVSDVKQKSFLTVNPHGTVAASVTTATVIPLS--------- ------------ITHTLDFKADQPFALIIMDKQNKL-----PLFFAKI---SKPSKPKDP FRRG---------------------------------------------- >AaSRPN11 Aa:21 Aa:N43798 AAEL003686 17 Aa_17 -----------------------------------------------MKMKLLIVLSACL AITIAQKNRRFNQKTTTTPPPSNDNEFFDDRRCDEMNLAAGSEVDPWACLCHQFQFQRET CESDIEKYLPSQPGSKVCKDHRHYYIGLDNRCNYDRALDSSNDPAGKAMQFALDLFRVA- -----DNKN--------PEENFIISPLSP----------------QVLLA------QLTE GC--SEK-------ARMEMVNGVKLN---GNEAAS--LVDALTAAS----NK-------- -----------------------------------------DSTANKVDIASVFFKSKDI K--LQTEFRDDA--KQNNIKM--------KDIDFSN----PQQ-AANAV----------- ------------------------------------------------------------ -----------------------------------NEWAST------------------- ------------------------------------------------------------ ----------QTRGNIPQ------------------------------------------ VITEQG---IAP----D------------------MMMLLMNAVYFKGTWLYKFNETL-T NRRALFESSK-------NKKM--PVHMMAQSNK-LRFG-EISYGVYSDFR-QGLRWVELP YD--------------------GDELSMIVLLPK--VR-LQLDEMLRHI--NGSHFQEIF DVIRR----NHNPIKIHLKM--PRFAIKSSVSLVEPLKK------------------LGI KEIF-EDDNPLPKL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------FKTPAKVGDVKQDAFLKVDEDGTTATAVSRVTIIPLS--------- ----------LNMYEDMDFVCDEPFMVMVVDKTRQI-----PLFMAKI---RKPEKS--- -------------------------------------------------- >CqSRPN11 Cp:SRPN51 CPIJ016697 leukocyte elastase inhibitor supercont3.864 (fixed) -------------------------------------------------MKILIILSVYI SFALAQGNRDRKQTIQRQQASDFHDPRSCNFDSDDKWACV-----------CEQLNLERQ TCESEIDRTLQLNPKYKICREVLPYYVAKGQCRIEATWSQSNNPSGKAMQFALDLFKAA- -----DPKN--------PDKNYVISPLSP----------------QILLA------QLTE GC--SDE-------ARNEMIKGIMLN---SGEAAS--LIRSLHETA----NK-------- -----------------------------------------DDAMNKLDIASIFYFSDTA N-------------------------------------------AVQEI----------- ------------------------------------------------------------ -----------------------------------NNWVSQ------------------- ------------------------------------------------------------ ----------KTRGNIQE------------------------------------------ IVSEQN---LSP----D------------------MSMLLLNAIYFKGTWRYKFNE---T NKRASFQIAQ-------NNKM--SVHMMKQTNR-LRFG-EINFGEYWDPD-TGLRWVELP YE--------------------GDQLSMVLLLPK--TR-FELDKNLEQV--TGAHLQDIF KVIKR----DYNPNKIHLQL--PKFTIKDSISLVEPLKK------------------LGV KQIF-ESDTALNKL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SKSPVKVGDVKQDSFLSVDEKGTTATAVSKITIIPLS--------- ----------LNAYEDIHFVCDEPFMVMIVDKTSEI-----PLFMGKI---KQPLKATPE NKKQG--------------------------------------------- >AgSRPN17 Ag:16 Ag:N11372 17 ENSANGG00000027363 ENSANGP00000031477 ENSANGT00000031945 L/S 2R8A TCLAG019799 NOVEL Ag_17 -----------------------------------------MVNFCSGQVTGHAGFFSFL VSSLYLTTAQTVQQFAYNTDFFFRNPSEIYPQPVYVPKSQQETIKTYEKIQFEDSSLRFP APKQNEQQQPQPQPPKTPGA----------------------------MQFAWNMMKMM- -----VLPR---------QDNTVICPILP----------------QTLLA------TLHD GA--DRA-------AQAELSSSLLAT----SQELGQIVRSQELAIR-------------- -----------------------------------------GSSVNRLDQAMAVFLGTDT K--ISKPIQDKA-LQNGVEFV---------PVNFLN----RNT-AAATA----------- ------------------------------------------------------------ -----------------------------------NDWVAR------------------- ------------------------------------------------------------ ----------KSQGLIRE------------------------------------------ IVAPTA---LDA----S------------------TRLLMASVIYFKGKWKFQFTK---T EP-GLFETAP---SADSRSPVAQLGPMMYQFNR-FRYG-EID-----FTNGHGMRWVELP YE--------------------SSSLSMVLMLPK--MR-HQLQQSAQQL--SVADVTEII TSLNQ----NRGTNKMHLTV--PKFNVFSSLSLVPALKH------------------LGL RSIF-DRASALQNL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------ANEPLVVRDVSQRTFISVDEQGTTAVSAASLAFVALS--------- -----A----APPPPIINFTVNEPFLMMIVDKIHEY-----PLFVGKI---VNPTLN--- -------------------------------------------------- >AaSRPN17 Aa:28 AAEL003697 17-like ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MLLS------NLID YA--TPL-------AKSELKQSVLLH---PDQLAS--IVAKLEKIS-------------- -----------------------------------------KSTVNTIEIASANFVAEDV K--LNNTYSTDV--RQRNVEV--------RRVDFSQ----PYL-AARNA----------- ------------------------------------------------------------ -----------------------------------NNWVSG------------------- ------------------------------------------------------------ ----------KTHNLINE------------------------------------------ ILNPSS---VSP----Y------------------TRLLLANTIYFKGMWKYTFIE---T NP-GKFEASP-------NNPR--QINKMFQLNK-LRYG-TLS-----FPDGNGLRWVELP YE--------------------GNRLAMLVFLPT--VR-HQLEASLRQL--KPYDLAKVM AAMRT----NYINTKVHLHM--PKFTLTDSVSLIPALQR------------------MGI HSIF-QDQDALQYI---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------ANESTMVSDVTQRSYMSVDEFGTKATSVASLSIVTLS--------- -----I----TPQFKDVQFDVDQPFLTMIVDKQERY-----PIFIGVI---NNPRE---- -------------------------------------------------- >CqSRPN17 Cp:SRPN52 CPIJ016698 serine protease inhibitor, serpin supercont3.864 75133 78195 Cp_SRPN17 'SRPN-INHIB' ----------------------------------------------MKPAYSVWQAFQTI CTATHHRDPVGCCNYVNQVARERPNMFLCPSDNGYFFSPNDCGQTIAISSRFGPDAIMFP TEDSELQTRSTQRQVA--------------------------------QQLGQVTSRPVV QKPLQMQGPVRRPQPLEDNDYEDVPPAVLVDTVGYQAMEFALNLFKQLLS------NLIE VA--SPA-------ARAELFRAIRLY---PEQLAK--LIQSLDRIS-------------- -----------------------------------------KSTVNTIETAAANFFARDS K--VNQTYHQAL--KLRDVDV--------IPVDFSH----PAQ-AARQA----------- ------------------------------------------------------------ -----------------------------------NNWVSE------------------- ------------------------------------------------------------ ----------KTHRLINE------------------------------------------ ILNPGS---VNA----Y------------------TRMVLANSIFFKGKWKYTFIK---T EP-STFQATP-------NRKI--SINSMFQLNK-LRYG-EKQ-----FADGNGLRWVELP YE--------------------GDNLAMLVFLPL--QP-HRLQEALRQL--QPYDLASIM AELHV----PYINTKVNLRL--PRFTLTDSVSLIPALQS------------------LGV NAIF-NDKDSLPYL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------NRDATLVSDVTQRSYLSVDEFGTKATSVASLSIVTLS--------- -----I----TPQFRDVKFDVDQPFALMIVDKQERY-----PVFIGQV---YEPQE---- -------------------------------------------------- >AgSRPN3 Ag:3 Ag:N8384 3 ENSANGG00000005827 ENSANGP00000007723 ENSANGT00000007723 T/I 2L26A EBI7723 Ag_3 -----------------------------------------MGIFHGRRWAAVLCCVFAL TIAATPRRFLQ----------------------------------------NRFTVDYEP FAGTWN------------------------------------------DDFDWSVIKEV- -----LHKA---------PGNAVISPLSV----------------KALLA------LLYE GSASRSE-------TERELQQALSGG----NSQAVPKLQDDLLQYK-------------- -----------------------------------------QQQQQNLLITDRIFYDTTV T--LLQKYHSII-AARYNATT--------QSVDFQD----TQS-AAAEI----------- ------------------------------------------------------------ -----------------------------------NAWIAQ------------------- ------------------------------------------------------------ ----------NTRGKIQS------------------------------------------ IIKPDL---LQD-----------------------ALMMLINTIYFKGSWSIPFPTNA-T VE-RPFFTGRMHTAGRYGGPR--SVPFMKQRERIFYYK-HAE-------Q-LGAQFLRLP YD--------------------SNQLSMIVVLPD--EQ-VSLGQLLSRL--TADAVHETL ADMS--------EEEVEIEL--PRFTITYSSSLRECLQQ------------------LGV SRVF-TDQAELPLISRG------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RTTPLKVSTILQKSCILVDEQGTEASAATEGTLVFTI--------- ------------LDQPVKFIANRPFLFLIYDEGKGN-----WLFAGKV---EDPQT---- -------------------------------------------------- >AaSRPN3 Aa:3 OG:3 AAEL005665 Aa_3 ---------------------------------------------MTPRVDRFLFLLLLI SISVNPNECRKSQ--------------------------------------RPRPASRFS EPTEPQPTQD--------------------------------------AQFDWQLIKDM- -----LRQD---------SRNVAFSTFSA----------------KFLLN------MLYE GTSIYSA-------TQQELNEPLKRS----PDIHETPKCVTIMNTL-------------- -----------------------------------------TKNAEQFLVSSRVFADSMV A--VSQKYATIL-DMQYNASI--------DNVSFQE----PEI-AANTI----------- ------------------------------------------------------------ -----------------------------------NSWVSN------------------- ------------------------------------------------------------ ----------STRGMIPK------------------------------------------ MVRAQN---IRD-----------------------SVLLLLNAIYFKGLWVNVFLPSA-T SI-QPFRTAS-------GQTV--QVPFMKQIQD-HYYA-DSK-------E-LNAQLVRLP YA--------------------DGRFSMIVVLPN--VN-SNLNELLNAL--TSESINEAI RSMD--------ETEVNLQL--PRFQIDYDCSLKSGLQQ------------------LGI NRIF-QDNAELGLIFRG------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GPVPAKVSDVLQKTVIVVDEKGSTASSASGSSLVFTI--------- ------------ASEPELFIVNRPFMFFIEEESTGA-----VVFAGKV---ENPAQ---- -------------------------------------------------- >CqSRPN3 Cp:SRPN45 CPIJ016298 plasminogen activator inhibitor 1 supercont3.775 93667 95213 Cp_SRPN3 'SRPN' -----------------------------------------MTQKKNRFFWCAVLLISLA FSGESLAARRRPV--------------------------------------GSRNAEIEP MPEPTQD-----------------------------------------DEFDWKLIKTI- -----FSRS---------PGNAAVSTFSA----------------KYLLN------MLYE GTSARTQ-------TQQELSGHLGRDAGVNPASPS--IVNTMGAI--------------- -----------------------------------------QTNPDQLISASRIFADEQV S--VTQKFTSTV-SMIYNSSV--------ENVNFQQ----GPQ-AAQTI----------- ------------------------------------------------------------ -----------------------------------NRWVSE------------------- ------------------------------------------------------------ ----------GTRGLIPE------------------------------------------ LVTPQS---ITG-----------------------SILLLANTIYFKGLWTHIFPEAA-T AT-QPFNTGD-------GRTV--QVPFMKQIVD-HYYS-EPP-------Q-LNAKVLRLP YV--------------------NGRFSMILILPN--EG-SNLNQLLTAL--SADSIHQAI KSME--------ETEVKLEL--PRFKIDHSTSLKEDLQQ------------------LGI NRIF-QDNAELGGISRG------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GQLPVKVSDVFQKTVIVVDETGSTASSASGSSLVFTI--------- ------------ATEPERFVADRPFLFFIEEESTGT-----VLFAGKV---EDPSQ---- -------------------------------------------------- >DmSpn27A Dm:12 Dm:N1007 CG11331 spn27A Dm_spn27A ------------------------------------------MTKMGGNLAVMLLSLFLS ALATGNGNSIPTTTTPQGVFETRTDK-------------------------LPGGAASVP SGAGIYDDIDTFVPFRSDSH----------------------------DPFSWHLLKTV- -----LQNE-------TADKNVIISPFSV----------------KLVLA------LLAE AAGAGTQ-------TQVELANTQTDI----RSQNN--VREFYRKTL----NSFKKE---- -----------------------------------------NQLHETLSVRTKLFTDSFI E--TQQKFTATL-KHFYDSEV--------EALDFTN----PEA-AADAI----------- ------------------------------------------------------------ -----------------------------------NAWAAN------------------- ------------------------------------------------------------ ----------ITQGRLQQ------------------------------------------ LVAPDN---VRS-----------------------SVMLLTNLIYFNGLWRRQFAT---T FQ-GSFFRSK-------DDQS--RAEFMEQTDY-FYYTTSEK---------LKAQILRLP YK--------------------GKN-SLFVLLPY--AL-NGIHDLVKNL--ENDELKSAQ WAME--------EVKVKVTL--PKFHFDYQQNLKETLRS------------------LGV REIF-EDSASLPGLTRGAD----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VAGKVKVSNILQKAGINVNEKGTEAYAATVVEIENKF--------- ----------GGSTAIEEFNVNRPFVFFIEEESTGN-----ILFAGKV---HSPTTQN-- -------------------------------------------------- >AgSRPN2 Ag:2 Ag:N8575 2 ENSANGG00000019323 ENSANGP00000021812 ENSANGT00000021812 K/F 2L26A agCP3768 Ag_2 -------------------------------------------------MNKLNFVILCL AALLVFDA-------------------------------------------TAQQDVHGP FQGQRQ------------------------------------------NEFDLMFVKEI- -----FKNH---------NSNVVLSPFSV----------------KILLT------LIYE AS--DTSFGNAVSNTKRELSSVIQND-----NIDH--TRSYYKQLL----ESAQQ----- -----------------------------------------DNKDYDLNIATNFFVDDFI E--VINKYQQIA-NTHYHAML--------EKVSYSN----PTQ-TAATI----------- ------------------------------------------------------------ -----------------------------------NNWVSE------------------- ------------------------------------------------------------ ----------HTNGRLRE------------------------------------------ IVTPDS---LEG-----------------------AVITLVNVIYFKGLWTYPFPEVA-N NV-KPFYGTR-------GKPT--NAQYMEQNGQ-FYYDNSAD---------LGAQILRLP YR--------------------GNKLAMYFILPN--PD-NTVNQVLDRI--NSASLHQAL WYME--------ENEVNVTL--PKFKFDFSEQLNEPLQQ------------------VGI REIF-SQNASLPLLARGRG----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------ARDEVRVSRIFQKAGITINELGSEAYAATEIQLVNKF--------- -----------GGDGVQIFNANRPFIFFIEDETLGT-----MLFAGKI---ENPVF---- -------------------------------------------------- >AaSRPN2 Aa:2 OG:2 AAEL014078 Aa_2 ------------------------------------------MIAGDNRLRTDWYLYLQS EFHSKLEFCVKALRSSLGNGFRLNRCKEICIVAS-----------------CTCTDDNFI NNDDQPFRGQRN------------------------------------VEFDWKLTKQV- -----FQSQ---------KANAVISPLSV----------------KILLV------LLYE AT--GDAAELSETQTKRELRTVLEPN----GDLNA--TRSKYRQWL----DSALS----- -----------------------------------------SHKDYDLEIATKFFVEEYI D--VISKYQIIS-DHYYSATV--------DKAPFSK----PKI-AAEQI----------- ------------------------------------------------------------ -----------------------------------NSWVNK------------------- ------------------------------------------------------------ ----------TTHGRIAE------------------------------------------ LVTADG---LDG-----------------------AVITLINAIYFKGLWTYPFPE---Y TPTLTFYGNQ-------KQV---QAPFMEQNGQ-FYYDDSAA---------LDSQLLRLS YR--------------------GGKFAMYFILPH--QG-KTVDDVLDKM--TLSTLHQAL WYMD--------ETEVNVTI--PKFKFDFSEELNQPLKD------------------IGI REIF-SQNASLPLLARGKG----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------ARNEVRVSRVFQKAGININHLGSEAYAATEIQLVNKF--------- -----------GGDGTQIFNANRPFLFFIEDEDFGT-----LLFAGRV---EDPTQ---- -------------------------------------------------- >CqSRPN2 Cp:SRPN47 CPIJ016301 serine protease inhibitor A3G supercont3.775 132208 134693 Cp_SRPN2 'SRPN' --------------------------------------------------MSAIFVIFCC VLAAFS---------------------------------------------VKATDVEIP DEGPFRDTRN--------------------------------------VEFDWKLTQSI- -----FSTQ---------RANTVISPFSV----------------KILLA------LLYE AS--NDAANIGETLTKRELRLVLEPN----GNLND--TRSKYRMFL----DSALK----- -----------------------------------------PNSLYDFQIGTKFFVDEFI D--VISKYQIIS-YEYYNATV--------DKVPFSK----PQV-AAKQI----------- ------------------------------------------------------------ -----------------------------------NDWVSK------------------- ------------------------------------------------------------ ----------TTNGRINE------------------------------------------ LVNAEG---VEG-----------------------AVITLVNALYFKGLWKYPFPE---N GPKRTFNAAG-------RKV---QANYMEQNAQ-LYYD-DSA-------T-LGAQLLRMP YQ--------------------GGKFAMYFMLPH--QG-QTVDDVVSRI--TPQSLHQAL WYMD--------ESDVNVTI--PKFRFDFSEEMNKPLQD------------------IGI REIF-STNASLPLLARGKG----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------TRDQVRVSKVFQKAGVTVNEVGSEAYAATEIQLVNKF--------- -----------GGDGTQIFNANRPFVFFIEDEHTGS-----LLVVGKV---EDPTK---- -------------------------------------------------- >AgSRPN1 Ag:1 Ag:N8384 1 ENSANGG00000019162 ENSANGP00000021651 ENSANGT00000021651 K/F 2L26A agCP3418 Ag_1 -----------------------------------------MRSAVPNSVRCYAVLMLLI SIGTVQPFRRH----------------------------------------HPRHQPSFV SR----------------------------------------------SDFDWNLAREV- -----FRHE---------DSNVVFSPFSI----------------KLLLT------LLYE AAEPGSG-------TRSQLEAALVDP-----DLNQ--TRAFYTQFL----DASQQ----- -----------------------------------------TNGDYEFDIGTKMFLDKAR A-KLPQAYTDLL-EQMYRTSV--------ERVSFNG----TKA-TAERI----------- ------------------------------------------------------------ -----------------------------------NTWCEK------------------- ------------------------------------------------------------ ----------VTRGRITE------------------------------------------ LVTEDT---LQD-----------------------AQLVLANVLFLKASWKNSFPDDQ-T HN-RTFHVAD-------GDTV--TTEFMRQMDL-YDYT-VHE-------Q-LGAEVLRLP YK--------------------GRQFSMNMVLPH--RN-VSLAALADAL--TPTMLDSIA EQFV--------REEVTVLI--PKFRFNYGTLLNEAIQR------------------LGI RDVF-TKNAALPLLASADDAKQST------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IKNEVQVSKMLQKAGIEINEKGTLAFAATEIQLVNKF--------- ----------GYDGEPIVFEANRPFLFYILDEETNA-----ILFVGKV---TDPSRSTP- -------------------------------------------------- >AaSRPN1 Aa:1 OG:1 Aa:N50024 AAEL014079 (same as AAEL005670) Aa_1 -------------------------------------MPAQCPRFGQSAVHMGVALLFLL NTSATLRNVGNH---------------------------------------RSNQLQNQP DAVLLN------------------------------------------NDLDWKLVKEV- -----FHHE---------QKNVIFSPFSI----------------KLLLS------LLYE ASKEHSK-------TRQELSLVLAGS-----DLEK--NRLLYQEFL----ESSTK----- -----------------------------------------ENSNYQFNVGTRIFTDQRA A-NVSDAYSDLV-QNCYKTSI--------ESVEFDS----PKE-TSSKI----------- ------------------------------------------------------------ -----------------------------------NEWCFN------------------- ------------------------------------------------------------ ----------ITNGHLKD------------------------------------------ LVDEEL---IKD-----------------------SVMVIVNALFLKASWRNSFKEEL-N RK-RNFYVSE-------NTTV--EAEFMEQTDI-YQYL-DDP-------D-MQLEMVRLP YK--------------------GRHFSMTIVLPY--AN-RSLGKMVESL--TDQNLLKLE SNLQ--------RDEIVVII--PKYKFDYSTTLNDVLIR------------------LGI TEVF-TDKAELPELSGG------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KNSTLAVSKMLQKAGIEVNEKGTLAFAATEIQLVNKF--------- ----------GIDDMPIQFKANRPFMFYIKDEDSDA-----VLFVGKV---ENPVATEKL P------------------------------------------------- >CqSRPN1 Cp:SRPN44 CPIJ016297 serine protease inhibitor A3K supercont3.775 85599 88377 Cp_SRPN1 'SRPN' --------------------------------------------------MTLLVLLASL VSSETVSQHQSNQIQTNLP--------------------------------LSLPPPPPP SLDPEVVSLN--------------------------------------NDFDWKLVKEV- -----FQRE---------QQNTIFSPFSV----------------KLLLT------LLYE AAGENST-------TKRELSKALVGV-----NLDK--SRELYREFL----ESSTK----- -----------------------------------------ENGNYEFNIGTRVYVDDDV A-NVTANYTELV-EWCYKTNI--------ERVDFGK----TTE-TVARV----------- ------------------------------------------------------------ -----------------------------------NDWCSN------------------- ------------------------------------------------------------ ----------ITHGHLNE------------------------------------------ LVTEDH---IKN-----------------------SVMIIANVLFLKASWRNSFDENN-T RK-REFHVSP-------NHST--KPEFMEQTDI-YAYL-DDP-------E-LQLEMVRLP YK--------------------GRLFSMYIVLPY--AN-RTLDQMVSTL--TADNLIKLE GKLL--------REEVVVVI--PKFKFDYGATLNDALTT------------------LGI SEVF-TNRASLPQLSGG------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LNETLQVSKILQKAGIEVNEKGTLAFAATEIQLVNKF--------- ----------GIDDNPIEFIAERPFMFYIKDEESDA-----LLFVGKV---QDPMVAPGT HGTTRNAI------------------------------------------ >DmSpn77Bb Dm:27 Dm:N10888 CG6663 Dm_Spn77Bb ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MKLG-------------FLGLFGM----------------VLMI-------MFYE GA--EGY-------TVNELRDVLGIY----VDYPT--LRRWYEDVR----AYHYL----- -----------------------------------------NSENTKLFSLRYAYYDDVG DLELVKGYNSVV-LEGVGEGNVVLREGRPRGVDFDQ------G-ASIII----------- ------------------------------------------------------------ -----------------------------------NDDIDK------------------- ------------------------------------------------------------ ----------ASHAKIFS------------------------------------------ SYSRRS---FNS----T------------------VTVLGITVSYFKAKWKYPFDKSQ-T KV-EQFYNDG-------GSPAG-KVEMMVQTGK-YAYVNNVK-------G-LQADVLELP FG--------------------EHELVMIVLLPK--SS-QGVNLVLYQL--KNLGLHRLL EKLEA----SKNETDVEVKL--PKFDTRSVLSLEDTVYD------------------AGL TDLR-NDFADLDKLLIAI------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GHRGACLTLYHQFARIVVDEEGLPNAVPQKSSGKNNI--------- -----------------KFHVNRPFAYLVLQKKHKL-----LIHSGVF---REGEIQ--- -------------------------------------------------- >DmSpn77Bc Dm:28 Dm:N10598 CG6289 8-like Dm_Spn77Bc -----------------------------------------------MKLGFLGLFGMVL SLRAHI---------------------------------------------CANTVDTKS LLQKMTDAR---------------------------------------LQFALNLLQME- -----STHL--------NLENFAMTPFST----------------WSLMI------MFYE GA--EGT-------TLKQIRDVLAIY----VDYPT--LRRWYEDVR----AYHYL----- -----------------------------------------NSENTKLFSLRYAYYDDVG DLELVKGYNSVV-LEGVGEGNVVLREGRPRGVDFDQ------G-ASIII----------- ------------------------------------------------------------ -----------------------------------NDDIDK------------------- ------------------------------------------------------------ ----------ASHAKIFS------------------------------------------ SYSRRS---FNS----T------------------VTVLGITVSYFKAKWKYPFDKSQ-T KV-EQFYNAG-------GSPAG-KVEMMVQTGK-YAYVNNVK-------G-LQADVLELP FG--------------------EHELVMIVILPK--PS-QRVSLVLKQL--KNLGLHRLL EELEA----SKNESDVEVKL--PKFDTRSVLSLEDTVYE------------------AGL TDLR-NEFADLGRMLIPT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GDRGAYLSLYHQFARIVVDEEGLPNAVPQKSSGTNNI--------- -----------------KFHINRPFAYLVLQRTHKL-----LIHSGVF---REGEIQ--- -------------------------------------------------- >DmSpn77Ba Dm:2 Dm:N10903 CG6680 OG:8 Dm_Spn77Ba ----------------------------------------MGKIADCLMLWIPLLLGAIF LCSADPQNNQAPLQLS-----------------------------------VGNPLTAFT APTAFQSGVSHIQSMRSNFDTDVLVSISQGV-----------------QDFALDLLQRI- -----SVEV------EKANKDFMISPFSV----------------WSLLV------LLYE GS--EGE-------TRNQLKKSLRIN----VEDEK--LRGAYKVWS----SFLNI----- -----------------------------------------TTSTIEVATLQAIYTGKGY P--IKNNYRDAI--QNYNVQP--------MEVDFYS----PD--SVIQI----------- ------------------------------------------------------------ -----------------------------------NEDTNR------------------- ------------------------------------------------------------ ----------TTRGLIPY------------------------------------------ TILPQD---VYG-----------------------AKMFLLSSLYFKGQWKFPFNKTL-T RE-EPFFSES-------GEVIG-KIPMMVQEAN-FAYVSNVE-------G-LDGYVLELP YG-------------------TQDRLAMIVVLPK--RG-FKLNDVANNL--KALGLRPIL QRLAAFRNRASEDNEVEVMM--PKFVTATDFTLKGVLIQ------------------MGI RDLFDENTANLDR----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MSSGLFAKLVVHSTKIIVDEQGTTAGAVTEAALANKA--------- --------------TPPKFLLNRPFQYMIVEKATGL-----LLFAGQV---RNPKAA--- -------------------------------------------------- >AgSRPN8 Ag:9 Ag:N26453 8 ENSANGG00000012210 ENSANGP00000014699 ENSANGT00000014699 K/A 3R14D TCLAG015624,NCLAG015623 agCP3027 Ag_8 --------------------------------------------MGRFVLECLAVCLLIT LVCCQQNGTFTFATSGDGG--------------------------------GGGGATDTP PGVDRLQRSS--------------------------------------QKFALQFYQYVT ELVDYNPNV--------TTTNIIVSPFSA----------------WNLLT------LITE GA--SGR-------TLDELLVALDVQ-----QQEQ--IRNYYKPFA----QSFSL----- -----------------------------------------LDRDVQLAAAQYVITDENR P--VSKDFESAL-DTFYSPSV-------LQPMNFAN----RSL-TYERV----------- ------------------------------------------------------------ -----------------------------------NRLVSD------------------- ------------------------------------------------------------ ----------ATQGQIPK------------------------------------------ AIEMSD---LED-----------------------ARLIMLSVLFFQGQWTIPFNRSF-T TN-VPFYDEN-------EQPIG-MVEMMFQRGI-FPFA-GYK-------E-LDAQILELP YG-------------------ANRRLSMLLIMPR--KG-VPLVEVIRKL--AAYGIDRVF DELDRSLV-DFDDDEVEVHL--PKFEFNSDYNLIPILNQ------------------MGI REAFDSGVANFDKIS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DLNAIYISSVIQQTKIVVNEEGTMTAAVTTGVFANKA--------- --------------TPPRFLANRPFGFMIVNRQQRT-----ILFAGQV---KRPNLV--- -------------------------------------------------- >AaSRPN8 Aa:14 Aa:N35763 AAEL011777 8 Aa_8 ------------------------------------------------------------ ------------------------------------------------------MIDRIP FQQ---------------------------------------------VSLTVDNDRNV- -----------------TTTNIFVSPLSV----------------WTLLA------LLSE GA--EGE-------TLREILEVMSVQ-----DQNL--IKHHFKSFQ----ETINV----- -----------------------------------------KANGVEISSAQFMFTDKNH P--VRHDFEHIV-DTYYGENL-------FEALDFSSSNESLRD-SYNYI----------- ------------------------------------------------------------ -----------------------------------NKVVSD------------------- ------------------------------------------------------------ ----------ATKGQIKR------------------------------------------ AIHPTN---LDQ-----------------------ARLLLLSVLFFQGEWTFPFNRSH-T NESTPFYDEN--------ERIVASVPMMFQKAI-LPFA-AFR-------E-LEAQIVELP YG-------------------SDRFMSMLVILPR--KG-VPLHEVVQRL--ANFNMEMIY KELRQVAE-EYEDDEVEVFL--PRFQISSDYVLKSVLFN------------------MGM REAFHTGLAQFNK----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IASDIVVNDIFQKNKIVVNEEGTTASSVSGAVFVNKA--------- --------------TPPRFIANRPFAFLIVDKRNDL-----ILFMGQV---KDPRTL--- -------------------------------------------------- >CqSRPN8 Cp:SRPN37 CPIJ013205 serine protease inhibitor supercont3.438 121550 125544 Cp_SRPN8 'SRPN' -----------------------------------------MARKGDGLLRWTIVLGLIC AVIS-----------------------------------------------QQSTVSQKL YEGS--------------------------------------------QKFALNFFKKIS EFVDSDPSV--------TTTNIIISPLSV----------------WTLLA------LLTE GA--DGK-------TLRELLDVLNVD-----NQND--IKYNFKNLI----DTINV----- -----------------------------------------NTSEVEISSLQLIFTDITQ Q--RQQAFDDSI-VQFYGQDL-------LRSLDFNSSPQARKN-SYETI----------- ------------------------------------------------------------ -----------------------------------NGIVSN------------------- ------------------------------------------------------------ ----------ATKGQIEK------------------------------------------ AIHPSD---LKD-----------------------AKMLILSVLFFKGDWTLPFNRSQ-T VD-TPFLNEN-------DVTVG-PVPMMYSKAV-FPFA-AFR-------E-LEAQIVELP YG-------------------SDRHLSMMVILPR--KG-VPLKDVIGRL--ANFSMQTIY QELRTAAE-EYEDDEVEVYL--PRFEITADYKLKAPLFD------------------MGV KAAMSKETAQFDR----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MANGIFLGDIVQKARIVVNEEGTTASASTAAIFANKA--------- --------------TPPRFFANRPFAFLIVDKRFDV-----ILFMGQV---KNPLAV--- -------------------------------------------------- >AgSRPN9 Ag:10 Ag:N25878 9 ENSANGG00000014191 ENSANGP00000016680 ENSANGT00000016680 S/S 2R14B TCLAG015554 agCP2980 Ag_9 ------------------------------------------MKLSTHLGTVAPLLLLTL LIVPHHGTNGQCSPGDEK---------------------------------KAEKATDLE QSRSRLYKGE--------------------------------------SIFTLRLLDAI- -----NTAT--------PNENLFFSPYSL----------------YNVLL------MMYF GA--RDT-------TEKLLRTSLNLQ--WADSKTT--VYEAYDTAR----KSLRGRFS-- -----------------------------------------ESNAVGFSSADKLFFGR-- ----QIPVSTCV-QQKFADTI--------ELLDYQT-Q--PDE-QRAYI----------- ------------------------------------------------------------ -----------------------------------NRWVEN------------------- ------------------------------------------------------------ ----------ATRGQIKD------------------------------------------ LLEPGA---ITR----N------------------TKLAVANAAYFKGTWQTKFKAAE-T NK-EIFYVSA-------DQQK--FVDMMHVEGT-FSHA-ANE-------K-LGCHILELP YSAGPGADNADDGPYQQGAANPDNQVSMFVFLPP-AEP-NALSKLLSRLAAETDILHEVV NEGI--------SRKVDVKL--PKFSIEKTVGMKPVLER------------------MGL GQLF-DQGANFDAFTDG------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------REPRSCFDEVLQKSKIEVNEEGSVAASATVAFSFRSS--------- -----------RPADPAMFHCNHPFVFLIYDYGTRS-----VLFNGVY---RQPE----- -------------------------------------------------- >AaSRPN9 Aa:15 Aa:N24010 AAEL008364-RA 9 Aa_9 ----------------------------------------------MRSLPTVVLLVVAL SARTISAQCLAQDDN------------------------------------IQHTKADNP LSRNRLYKGE--------------------------------------SIFTLKLLEAI- -----NTAT--------PTENVFFSPYSL----------------YHVLL------LAYF GA--RAE-------TEKMLRNGLELH--WTEDKPV--VWQAYNIGK----KSLAARFS-- -----------------------------------------QSGDIQFTSVDKLFFGK-- ----QVAIRDCM-EDKFFEEI--------EKLDFEK-D--ADG-QRLYI----------- ------------------------------------------------------------ -----------------------------------NNWVEN------------------- ------------------------------------------------------------ ----------VTYGEIKD------------------------------------------ LLIPGS---ITK----Q------------------TKLAIANAAYFKGTWQTEFKPEQ-T KK-EIFYVSS-------ERQE--FVDMMHVLGT-FSHA-ANE-------K-LGCHVLEMP YK----------------GQDESTRISMFVFLPP--AVPNSLEQLLARLTSDTGILSEIV NEGI--------PRMVDVKF--PKFNIEKTVELKPVLER------------------LGL GKMF-ENGADFTAFS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EKEQIGFDEILQKSKIEVNEKGSTAASSTVLFSFRSS--------- -----------RPVEPAMFHCNHPFVFLIYDYGTQA-----VLFNGVY---RQPE----- -------------------------------------------------- >CqSRPN9 Cp:SRPN32 CPIJ011775 serpin B6 supercont3.384 112746 114929 Cp_SRPN9 'SRPN' -----------------------------------------------MKFFASIVALLLT AAVAANAQCLAEDDN------------------------------------VQHTKTDNP LARTRLYKGE--------------------------------------SIFTLKLLEAI- -----NAAT--------PSENVFFSPYSL----------------YHVLL------LMYF GA--KSD-------TEQTLRKGLELH--WTEDKPV--VWQAYNVGK----KALAMRFGQN -----------------------------------------KADEIQFVSVDKLFFGKQI P------VEECM-EDKFFDEI--------EKLDFEK----DPESQRLYI----------- ------------------------------------------------------------ -----------------------------------NNWVEN------------------- ------------------------------------------------------------ ----------TTHGEITD------------------------------------------ LLIPGS---ITK----N------------------TKLAIANAAYFKGTWQSKFKPEE-T KK-EIFYVSN-------ERQE--FVDMMHVEGT-FNHAANEK---------LGCHILELP YT----------------GQDEASRVSMFVFLPP--TESNALDKLLARLTSSPDILSEVV NEGI--------SRRVDVKL--PKFSIEKTVDMKTVLGR------------------LGM GKLF-ENSANFSGFS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KKAQIGFDEVLQKSKITVNEEGATAASATVAFSFRSS--------- -----------RPADPAMFHCNHPFIFVIYDYATQA-----VLFNGVY---RQPE----- -------------------------------------------------- >DmSpn5 Dm:1 Dm:N5436 CG18525 OG:9-like spn5 Dm_spn5 -----------------------------------------------MHILSISLMAVLP AIALAGL--------------------------------------------CGVEPDAGL LDQRLNLYKGQ-------------------------------------QNFAVSMLNVI- -----RQST--------PNENVFFSPYST----------------YHALL------LAYF GS--SGD-------TEKELAKVLHLDWADSKEVVR--SAYILEKMN----RKERQ----- -----------------------------------------SKMPLEFSSADRIFFAN-- ----DLHVTECA-RNRLAEEV--------QQIDFKS-Q--TEE-SRKQI----------- ------------------------------------------------------------ -----------------------------------NDWIAK------------------- ------------------------------------------------------------ ----------QTHDQIRN------------------------------------------ MLSADE---ITP----R------------------TRLVLANAAYLKGQWLSQFKTEK-T VP-MPFYTSP-------SNYS--LVSMMQQKGT-FLLN-VDE-------Q-LRAHVLQLP YR-----TVFESQEKEDSSPDENSDISMVLILPP--FNSNSLEDVLSRL--NADSLDDSL KQAM--------PREIEVSL--PKFEFEQRLELNPILAK------------------MGV SKMFDESVATFDDL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------TSETISIGDSKHVAKIKVDEEGSTAAAATVLFTYRSA--------- -----------RPVEPAKFECNHPFLFVIYDRTSRS-----ILFTGIY---RDPKTIKQ- -------------------------------------------------- >DmSpn88Eb Dm:16 Dm:N10908 CG6687 9-like Dm_Spn88Eb -----------------------------------------------MHTFSLVLLALLP VVTIAA---------------------------------------------LDKPELSFL NEFSQIFKGE--------------------------------------RDFSLALMKQI- -----REIY--------PSGNLFFSPFST----------------YNALL------LAYF SS--SEQ-------TERELAQALNLG--WALNKQQVLVSYTLAQRQ----DEFRW----- -----------------------------------------RQSPMELSSANRIFVDRTI N--VSNKFNTLL----YGATK---------ELDFKN----DPETGLKEI----------- ------------------------------------------------------------ -----------------------------------NDWIAD------------------- ------------------------------------------------------------ ----------KTHNQIRD------------------------------------------ MLSSEE---ITP----H------------------TMLVLANAAYMKGQWLSQFKVEE-T AL-KPFFINE-------REQE--MVYMMHKTGA-FKMTIDEG---------LQSQIIKLP YR-----TIYKSKETHISTPESKSDISMIIILPN--SNKISLNRVISRL--NADSVKKWF ERAL--------PQKIELSL--PKFQFEQRLELTPILSL------------------MGV NTMF-TRNATFGDLTA-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DPISLVIDDAQHLAKIKVDEVGSTAAAATILLVSRSS--------- -----------RQPDPTKFNCNHPFVFLIYDEKVDT-----ILFAGVY---SDPRQMQH- -------------------------------------------------- >DmSpn43Ab Dm:25 Dm:N5507 CG1865 Spn43Ab Dm_Spn43Ab -------------------------------------------------MAVIISCLLLL LATVSQ---------------------------------------------SKTVGYDAA ADR---------------------------------------------NLLAADLYNAV- -----AADH--------LNENVVISPATI----------------QSSMA------LAFV GA--KGQ-------TASELQQGLRLGPGDADAVSQ--RSGSYQQAL-------------- ------------------------------------------TRDNNFRLANNIYINENL E--FKGSFRDVA-QRQFDSNI--------DKLDFHP--PYNKR-TADGI----------- ------------------------------------------------------------ -----------------------------------NRAVAT------------------- ------------------------------------------------------------ ----------KTNGKITD------------------------------------------ ILRAEL---LND----R------------------TEGVIVNGVSYSAAWQKAFRLDK-T EK-RSFRTGS-------GQSV--KVDTMWTLQN-FNYA-EVN-------S-LDAKVVELP YQ--------------------NPDFSMLLLLPN--RK-DGLRSLQQSL--SGKNLLAEI GAMS--------QQKVEVLL--PKFSVTFGLGLEGPFKK------------------LGV HTMF-SRDGDFGNMYR-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MFVSHFINAVEHKANVEVTEAGVDQPLETGLLKGLFS--------- --------------RSKKFEADHPFVFAIKYKDSIA-------FIGHI---ANYAYV--- -------------------------------------------------- >DmNec Dm:11 Dm:N5463 CG1857 nec Dm_nec ---------------------------------------------MASKVSILLLLTVHL LAAQTFAQELIAWQRQQQQQQQQQLQLQQQLLLQQQQHQRNPRPELGLRSLPGNPWTQNN QEAISDVVAVDLTKREPVTPPPNRPPPVFSYM----------------DRFSSELFKEI- -----IKSQ--------SQQNVVFSPFSV----------------HALLA------LIYG AS--DGK-------TFRELQKAGEFS----KNAMA--VAQDFESVI----KYKK------ -----------------------------------------HLEGADLTLATKVYYNREL G-GVNHSYDEYA-KFYFSAGT--------EAVDMQN----AKD-TAAKI----------- ------------------------------------------------------------ -----------------------------------NAWVMD------------------- ------------------------------------------------------------ ----------TTRNKIRD------------------------------------------ LVTPTD---VDP----Q------------------TQALLVNAVYFQGRWEHEFATMD-T SP-YDFQHTN-------GRIS--KVAMMFNDDV-YGLA-ELP-------E-LGATALELA YK--------------------DSATSMLILLPN--ET-TGLGKMLQQLSRPEFDLNRVA HRLR--------RQSVAVRL--PKFQFEFEQDMTEPLKN------------------LGV HQMF-TPNSQVTKL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MDQPVRVSKILQKAYINVGEAGTEASAASYAKFVPLS--------- -----------LPPKPTEFVANRPFVFAVRTPASVL-------FIGHV---EYPTPMSV- -------------------------------------------------- >DmSpn28B Dm:7 Dm:N10936 CG6717 Dm_Spn28B ---------------------------------------------------------MKY LCKRSTKSYF-----------------------------------------TLQQFSLIP LDLLLLATSVE-------------------------------------SGFWEDFYRIL- -----ASQN--------AKRNLIYSPISA----------------EIIMS------MVYM AS--GGK-------TFEELRNVLKFS----ENKTL--VANNYRSLL----SDLKR----- -----------------------------------------RETFIILHMANRIYVNKKY C--LVPEFNQLA-RKAFKAKA--------KSIRLDD----PVS-ASAIV----------- ------------------------------------------------------------ -----------------------------------NSWILN------------------- ------------------------------------------------------------ ----------RTRGMIRN------------------------------------------ IVLPKD---FNS----D------------------TSAFLVNAIYFKGQWLYNFKADQ-T HI-ADFYVSA-------NEII--PVKMMTLSAS-LLSG-YID-------D-IDAKIIELP YW--------------------NSTLSMRIILPN--SV-DGLRKLKEKV-------GFID YHLE--------KKSVNVKL--PKFKIESKAQLKGIFEN------------------LGI LDVF-KPSADLNGLV--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LESGAKIDKIVQKAFLKIDEKGGEASAATGVLTRRKK--------- ---SID----NLIQPPMEFIADHPFFYVIHDNKVIY-------FQGHI---VEPRW---- -------------------------------------------------- >DmSpn1 Dm:10 Dm:N13053 CG9456 spn1 Dm_spn1 -------------------------------------------------MYYLCIFLWVT SVA--------------------------------------------------------- ------------------------------------------------CQTSKEIYQLL- -----SKSH--------TNQNLVVSPVSI----------------ETILS------MVFM GA--EGS-------TAKELQSALGLP---SEDKEA--VAARYGALL----NDLQG----- -----------------------------------------QEEGPILKLANRIYVNDQY S--LNQNYNLAV-REPFKSEA--------ESISLTN----GPV-AAERI----------- ------------------------------------------------------------ -----------------------------------NQWVLD------------------- ------------------------------------------------------------ ----------QTSGKIKG------------------------------------------ MIDPGS---MTS----D------------------VKALLVNAIYFKGQWESKFDPAK-T RA-STFQVTA-------NKSV--PVQMMAQMGT-FRAN-YFR-------D-LDAQVIELP YL--------------------NSNLSMTIFLPR--EV-EGLSALEEKI-------VGFA RPLV--------AKEVYLKL--PKFKIEFRDELKETLEK------------------LGI RELF-TDKSDLSGLFA-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DKSGGKVSQVSHKAFLEVNEEGAEAAGATSVAVTNRA--------- -------------GFSTFLMADHPFAFVIRDANTIY-------FQGRV---VSP------ -------------------------------------------------- >DmSpn2 Dm:4 Dm:N12037 CG8137 spn2 Dm_spn2 ------------------------------------------------------MKHLCL LLLATSVS---------------------------------------------------- ------------------------------------------------CRFADDFYQLL- -----AKEN--------AANNLISSPLSV----------------EIALS------MAYM GA--RAK-------TAQEMRNVLKLP----DDKKE--VAAKYKDLL----SKLEG----- -----------------------------------------REKVATLSLANRIYVNKKF Q--LVPSYNQMV-KDSFMAEA--------EAIDIVD----PNK-ASSIV----------- ------------------------------------------------------------ -----------------------------------NNWVDN------------------- ------------------------------------------------------------ ----------QTRGKIKD------------------------------------------ LVSSND---MSK-----------------------MELIVLNAIYFKGQWEYKFNPKL-T KK-RNFRVSD-------QKSV--PVEMMSLFQS-FRAA--HD-------SELGAKIIELP YR--------------------NSSLSMLIFLPD--QV-DGLSELEKKI-------VGFK PKLS--------KMDVTLRL--PKFKIEFFAQLNKVLVA------------------MGI QDAF-EKSADFKDLV--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------ENSNVHVKKVIHKAFIEVNEEGAEAAAATALLFVRYS--------- -----M----PMPSSQMVFNADHPFAYVIRDRETIY-------FQGHF---VKPNE---- -------------------------------------------------- >DmSpn3 Dm:15 Dm:N12959 CG9334 spn3 Dm_spn3 -------------------------------------------------MKYLCLLLLAT SVS--------------------------------------------------------- ------------------------------------------------CRFTDDLYQLL- -----AKEN--------ADKNLITSPLSV----------------EIALS------LAYM GA--RGK-------TAQEMRDVLKLP----DDKKE--VAAKFKDLL----SKLEG----- -----------------------------------------RESVAILSLANRIYVNNKF K--LVPEYNQMV-KDSFKAEA--------EAISANN----PKI-TASIV----------- ------------------------------------------------------------ -----------------------------------NKWVDT------------------- ------------------------------------------------------------ ----------QTSGKIRD------------------------------------------ LVMPSD---VAN-----------------------LVLVILNAIYFKGQWQKKFNTEQ-T K--SDFHISD-------QKSV--PVQMMSLVRP-FGVS-YDR-------E-LGANVIELP YR--------------------NSNLSMVIFLPD--KV-DGLPELEKKM-------VGFT PKLI--------NINVHLRL--PKFKIEFSARLEQVLIA------------------MGI QDAF-KTSADFNDLV--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------ANSGAHVGGVVHKAFLEVNEEGSEAAAATAVVFRYKS--------- -----------IRSPPMDFNVNHPFAYVIRDAENIY-------FQGHF---VNPEL---- -------------------------------------------------- >DmSpn28Da Dm:8 Dm:N7217 CG31902 Dm_Spn28Da ---------------------------------------------------------WIL VTTSVL------------------------------------------------------ ------------------------------------------------GQFTKQLYRSF- -----LQDN--------KQYNIIASPLCV----------------EIGMS------MILM GA--DGN-------TANELRTALNLP----EDKKN--VATIYDKLL----TKLER----- -----------------------------------------GKKVAILHLANRLFVNETI G--VNKRYNKLV-NKHFRAEA--------EAIKLAD----RLK-AAWAI----------- ------------------------------------------------------------ -----------------------------------NDWVLD------------------- ------------------------------------------------------------ ----------QTLDNVKD------------------------------------------ IIIPSD---LTP----D------------------ESAVMINAAFFKGYWKTRFDKMN-T KP-KVFYVSK-------SYQV--NVNMMSQVGR-FKMR-TST---------ID-QIIELP FA--------------------YSNLSMVIVLPK--DN-GSLTQAEATI----ESYPQI- -VLT--------EMDVHVQL--PKFKIDFRMELVETLKSVSRFCSPYLIYYMFLNLQMGI QDLF-NSSSDISVLL--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------NQSGTRISQVVHKAFIEIDEEGGSAGSASASPIRGLSGKLWHICIM FLLDCLWYFSDYATSVVTFTVNSPFVFMIRDDDNIY-------FRGRV---VDPLKKSNP IDRITI-------------------------------------------- >DmSpn28Db Dm:20 Dm:N8103 CG33121 Dm_Spn28Db ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MDKA---------ESNFIASPLCI----------------EIGIS------MILM GA--KGT-------TAEELRSVLDLP----VDVTE--MAKKYERIM----SNF------- ------------------------------------------QKHNGLRFTNWLYVNETY E--VRQDYNTLM-KSTFMAE---------GKDPLSQ-----RK-ASNSI----------- ------------------------------------------------------------ -----------------------------------SFSIHR------------------- ------------------------------------------------------------ ----------KSHKGMRT------------------------------------------ ISNDHN---LQI----N------------------ESAVLVNTVYYSGAWKTRFSKKD-T KL-KVFHGDH-------NKKV--YVRMMSHVGR-FRIA---D-------H-SYGQIIEMP FD--------------------NSDLSMIIGLPL--HN-TYLSSIEKIL-------RTLS ESLV--------ENNVHVEL--PKFKIKYQTELVESLKK------------------LGI HLIF-SNTSDLSGLLT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------NGTGAKINHVVHKSFIEINERGASTGEASDHAES------------ -------------------------------------------IQSTL------------ -------------------------------------------------- >DmSpn42De Dm:9 Dm:N13056 CG9460 10-like Dm_Spn42De ---------------------------------------------MSVKATCSLLLLQGL NLAMA----------------------------------------------NTLNYSKSP AGE---------------------------------------------AQFASQLFGQL- -----AKSQ--------SGRNIVFSPSSI----------------RTGLA------LAYL GA--EGS-------TADELKLGLGLE---GAGKTE--VAEKLDQLL----AKGQWEKASG -----------------------------------------DEDVPKLKYANRIFVTQRF K--LTQTYQDLV-SKNFAAAA--------ENVNFTQ----KAD-TAKHI----------- ------------------------------------------------------------ -----------------------------------NSWVEE------------------- ------------------------------------------------------------ ----------QTHQQIKD------------------------------------------ LIAPES---LDA----D------------------TSAILVNAIYFKADWQSSFPDYA-T YA-SDFVNHG-------GRKV--SVDTMSQEDY-FRFG-ELT-------E-LKAKVVELP YT--------------------GTDIVFLIILPQ--EE-QGLAIVEEKL--MGIDLNEIS SQLR--------RRKVRVQL--PKFKFEFDVPLQAALEE------------------LGI KKLF-SPGANLSSLYQ-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSEPLRISEVKHKAIIEVNEKGTTASGATFIKVSVES--------- -----L----TIGEEVFEFIADHPFFFAIKDAQNTL-------FLGHV---SQL------ -------------------------------------------------- >DmSpn43Aa Dm:26 Dm:N1574 CG12172 Spn43Aa Dm_Spn43Aa ---------------------------------------------MNHWLSIILLGVWIS ---------------------------------------------------APEGLGNTI KDR---------------------------------------------NLFATELFQTL- -----ATDR--------QDENVIISPVSI----------------QLALG------LAYY GA--EGR-------TAAELQKTLHAS----AKESKDGLAESYHNLL----HSY------- -----------------------------------------IKSKTVLEIANKVYTRQNL T--VSSHFREVA-QKYFDSEV--------EPLDFSR----ETE-AVEQI----------- ------------------------------------------------------------ -----------------------------------NRWVKQ------------------- ------------------------------------------------------------ ----------QTENKIER------------------------------------------ VVES-----LEP----D------------------TNVALVNAIYFKARWARPFNDED-T RD-REFWLSE-------SRSI--QVPTMFADNW-YYYA-DYP-------E-LDAKAIELF FE--------------------NINLTMWFILPN--QR-SGLQALEQKL--KGVDFNLLE DRWQ--------WQSVSVYL--PKFKFEFDTDLRPTLHK------------------MGI SAMF-SDAADFSNIFQD------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SPIGTRITKVQHKTFIDVNEIGCEAAGASYAAGVPMS--------- -----------LPLDPKTFVADHPFAFIIRDKHAVY-------FTGHI---VKF------ -------------------------------------------------- >DmSpn42Db Dm:14 Dm:N13051 CG9454 Dm_Spn42Db ------------------------------------------------------------ -----------------------------------------------------MKDEEFA QGL---------------------------------------------EQFALCLHDHL- -----CRAS--------AGLNIIYSPLSI----------------HISAA------MLRM GTSEGSA-------TAKEMDEGLRFG---GLEAQQ--VAESFGVVL----KS-------- -----------------------------------------YEQCQVLKMANGLYVMKGL Q--VDEQFGHIL-EQKFRSKP--------MEIDFGS-----EQ-AASII----------- ------------------------------------------------------------ -----------------------------------NKWVES------------------- ------------------------------------------------------------ ----------QTNNLIKD------------------------------------------ IIGPRV---LTK----D------------------SRLCLVNGIHFKGEWSISFNEKE-T RE-EDFFGSD-------RPT---RVRMMHVCEN-FFFA-VLP-------M-FEATALRMN YS--------------------ACNLAMIILLPD--EK-SNLTSLEKKL--SDISLEVVS SAMN--------LEKVDVKI--PSFTAEFQQELSQVLML------------------MGM NRIF-SGQAELGGMLQ-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SEESLFVSQIVHKAFIEINEVGTEAAAATAAVATFRS--------- ----MP----ARQGPPKVFHANRPFFYAIKDNTHGL-----L-FAGHF---ITTKVEQSE KCNTCT-------------------------------------------- >DmSpn6 Dm:6 Dm:N676 CG10913 spn6 Dm_spn6 ------------------------------------------------------------ ---------------------------------------------------MFDFNLEFA RGG---------------------------------------------ARFTSELFQLL- -----SAGG--------LKENVVFSPFSI----------------QTCIA------LAFA GS--QGE-------TADEIAKALHFV----SNFPPE-VAQTFQFVL----EK-------- -----------------------------------------YRNSNLLRVANKLYVQEGK Q--LKPAYQSAI-KEQYHSEA--------ESINFAL----NDA-AAQAI----------- ------------------------------------------------------------ -----------------------------------NAWVNA------------------- ------------------------------------------------------------ ----------KTQGKITE------------------------------------------ LVSADS---FSD----N------------------TRLVLLNALHFKGSWAHKFSEER-T EE-DIFWVGE-------EEQV--KINYMNQKAK-FNYG-FFE-------D-LGCTALEMP YQ--------------------DSDLSMFVLLPQ--ER-TGIYALAEKL--KTVNLVDLA DKLT--------VEEVHVKF--PKFKVDYSLELAEKLKQ------------------LGI TKMF-TDQAEFSNLLE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SPEGVFVSKVLHKATIEVNEEGTEAAAATGMIMMTRM--------- ------------MTFPLQFQADRPFLYVIWNKKNIL-------FAGAF---VKAA----- -------------------------------------------------- >DmSpn4 Dm:5 Dm:N13050 CG9453 OG:10 spn4 Dm_spn4 ------------------------------------------------------------ ---------------------------------------------------MADAAHQEF ARRL--------------------------------------------ALFSINVYGKL- -----SGQK--------PGENIVFSPFSI----------------QTCAA------MARL GA--ENE-------TATQLDQGLGLA---SSDPEQ--IAHSFHQVL----AA-------- -----------------------------------------YQDSQILRIANKIFVMDGY Q--LRQEFDQLL-SKQFLSAA--------QSVDFSK----NVQ-AAATI----------- ------------------------------------------------------------ -----------------------------------NNWVEQ------------------- ------------------------------------------------------------ ----------RTNHLIKD------------------------------------------ LVPADV---LNS----E------------------SRLVLVNAIHFKGTWQHQFAKHL-T RP-DTFHLDG-------ERTV--QVPMMSLKER-FRYA-DLP-------A-LDAMALELP YK--------------------DSDLSMLIVLPN--TK-TGLPALEEKL--RLTTLSQIT QSLY--------ETKVALKL--PRFKAEFQVELSEVFQK------------------LGM SRMF-SDQAEFGKMLQ-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SPEPLKVSAIIHKAFIEVNEEGTEAAAATGMAVRRKR--------- ----AI----MSPEEPIEFFADHPFTYVLVHQK-DL-----PLFWGSV---VRLEENTFA SSEHDEL------------------------------------------- >AgSRPN10a Ag:11 Ag:N7866 10 ENSANGG00000013344 ENSANGP00000015833 ENSANGT00000015833 K/R 2L21E agCP14891 Ag_10 ------------------------------------------------------------ ---------------------------------------------------MADNSSSLD AQFVSQS-----------------------------------------NSFATKLYQRI- -----SAKH--------AGENVVISPFSI----------------SACLS------LAAM GA--GGL-------TAEQMYSVLEFG---APDRKQT-VADNYRRLM----ER-------- -----------------------------------------LATDSTVNVANKIYVMQNY A--VKGAFNAIA-TGSFRSEA--------ESVNFAE----SAA-AAKKI----------- ------------------------------------------------------------ -----------------------------------NGWVEE------------------- ------------------------------------------------------------ ----------KTNNKIKD------------------------------------------ LISPDA---LDE----L------------------SRMVLVNAVHFKGTWTYQFDPSL-T RP-FPFWLSE-------TESR--DVPMMNIKKH-FAFN-NFE-------E-LGFSALELT YG--------------------GSDMTMMLLLPN--ER-MGLAALEEKL--PTLNLAELA GKMH--------KQEVEVFL--PKFKIEFTRDLNEDLQA------------------LGM ERMF-SDSAEFPDLLE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------QNEPMKVSKVVHKAFIEVNEEGTEAAAATAAVVRVKR--------- -----------ALINRLKVRLDHPFLYALMMGSSRQ-----TAFVGRL---VKPDQSDVA QANRHEEL------------------------------------------ >AaSRPN10a Aa:16 Aa:N21586 -A AAEL007765 -RA 10 4 transcripts Aa_10 ------------------------------------------------------------ ---------------------------------------------------MAQTVDAQF VRKT--------------------------------------------NDFALDLYKQI- -----IANE---------KKNVVISPFSI----------------STCLS------LAAM GA--GGL-------TAEEMFRGLKYD---PAQKSS--IAESYGNIM----KN-------- -----------------------------------------LDGNKSLKIANKMYIMQKY S--VKSNFHEIA-QKGFRSEA--------ESVNFQD----NTA-TAKKI----------- ------------------------------------------------------------ -----------------------------------NTWVEQ------------------- ------------------------------------------------------------ ----------KTNDKIKD------------------------------------------ LISPDS---LDD----M------------------TRLVLVNAIHFKGTWTHQFNPES-T RP-MPFWISE-------TESV--DVPMMNTKKH-FKHG-VFD-------D-LGLAALELT YS--------------------DSDVSMLILLPH--ER-TGLSKLEENL--HNIDIPDML TKMH--------SQEVEVFL--PKFKIEFDLDLKETLEK------------------LGM GTMF-SDSADFSELLE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------QNDPLKVSKVVHKAFIEVNEEGAEAAAATGTVVRMKR--------- ----------SAPFPPTLFRADHPYLFVLLKDSHHLFVGRKVVASGNM---QTPHDEL-- -------------------------------------------------- >CqSRPN10Aa ------------------------------------------------------------ ---------------------------------------------------MTSALDIQF SSKT--------------------------------------------NEFALELYKQI- -----ISSE---------NKNVIISPFSI----------------STCLS------LAAF GA--AGH-------TANEMFSVLKYT----DAELKAAVALIYGKVL----KD-------- -----------------------------------------FNANPTVKIANKVYVMNKY S--VKAGFDEVA-RKNFHSEA--------ETVNFGE----NVI-AAKKI----------- ------------------------------------------------------------ -----------------------------------NGWVEQ------------------- ------------------------------------------------------------ ----------KTNDKIKD------------------------------------------ LISPDS---LDG----S------------------TRLVLVNAIHFKGTWKQQFDPEV-T KP-MPFWVTA-------TESV--DVPMMMNKKH-FRYG-KFD-------E-LGLSALELT YS--------------------DGDWSMLILLPN--DR-DGLAKLEANL--QNIDVVDLL SRMR--------RQEVEVFL--PRFKAEFELDLTETLKQVCNCLDLKNAN-------LGM GTMF-TDKADFSELLE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------QPEPVKVSQVVHKAFIEVNEEGTEAAAATELMAVNYC--------- ------------YIKPRKFHAKHPFCFVLLDKHTNF-----IMFNGHL---LDPK----- -------------------------------------------------- >CqSRPN10Ba ------------------------------------------------------------ ---------------------------------------------------MATEIDAQF ASKT--------------------------------------------NDFALELYKQI- -----ASSD---------KKNVIISPLSI----------------STCLS------LAAC GA--AGE-------TAEEMFSVLKYD----GAAQKQSVAQQYGRVL----AG-------- -----------------------------------------LNANPTLSIANKVYVMDKY T--VKAGFSEVA-QKSFYSEA--------ETVNFGE----NDA-AAKKI----------- ------------------------------------------------------------ -----------------------------------NGWVEQ------------------- ------------------------------------------------------------ ----------KTNDKIKD------------------------------------------ LISSDC---LGQ----D------------------TRMVLVNAIHFKGTWKHQFDKQQ-T IP-MPFWISA-------TESI--EVPTMNIKKH-FNYG-VFE-------E-LNASALELT YS--------------------DGDLSMLILLPN--ER-DGLPKLEEKL--QSINIADLT SKMY--------SQEVEVAL--PKFKIEFDVDLKETLEK------------------LGM GTMF-TDKADFSELLE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------QPDPLYVSKVVHKAFIEVNEEGTEAAAATAVMFQIEC--------- -----L----VVCTQSIEFIVDRPFYFALYDKKSNM-----FAFNGRL---QIPQ----- -------------------------------------------------- >DmSpn42Dc Dm:13 Dm:N13052 CG9455 Dm_Spn42Dc ------------------------------------------------------------ ---------------------------------------------------MSEPQEGR- ------------------------------------------------NQFARNLIDVIT KDALQQSKD--------PHINTVFSPASV----------------QSALT------LAFM GA--SGS-------TAEELRNGLQLG---PGDRHH--IALNFGEFW----RTSCNY---- -----------------------------------------GDRGPVLKSVNRLYVNDSL E--LLTEFNEIA-VDFFQSKA--------EATRFAD----SEG-ATQLI----------- ------------------------------------------------------------ -----------------------------------NDWVEQ------------------- ------------------------------------------------------------ ----------ETEHKITN------------------------------------------ LLQSDA---VNN----E------------------TSALLINVLYFKGKWQKPFMPET-T SI-DHFHVDR-------DTHV--QVNMMYQEDK-FRFA-ELP-------Q-LKARAVQLP YD--------------------YSNIHMLILLPN--EV-NGLQELEQQL--NTVDLADID AALT--------LQDVEIFL--PRMCIEYDVDLKQVLNQ------------------LGI TEVF-SDKAKLDGLFT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SQSGQKISAARHRGYIDVNEAGSEAAAVSFMKIVPMM--------- -----------LNMNKKLFKADHPFVFYIRNPQAVF-------FAGRF---SNPKSGSGS GEEGLSREGFDANMYNV--------------------------------- >DmSpn47C Dm:23 Dm:N11716 CG7722 Dm_Spn47C ------------------------------------------------------------ ---------------------------------------------------MASGGTTAP SLSASP------------------------------------------IVFARNLFRAL- -----NDEV--------PPVNMMVSPAGA----------------RSAMT------LVFM GA--GGK-------SADELRSKLILG---VSNKSE--VAKQHAESW----TDECSC---- -----------------------------------------AKKGVALRLVTRLYVNEEE K--IRTDFNDMA-LEFFNAEA--------YSLNYLN----PED-SVKKV----------- ------------------------------------------------------------ -----------------------------------NKWLEK------------------- ------------------------------------------------------------ ----------HTFYTVRN------------------------------------------ LFTPEV---FNS----D------------------SSVILVNSLFFRAKWNKIFPQQL-T QI-DDFWINP-------RQRM--EVSMMRQIGQ-FRYG-ESK-------K-LKSQILQLP FE--------------------RSNLTMMIILPT--AI-DGLPELEEKL--GQLDMNEVA AKSL--------MKEVDVTI--PKFRIECTVDLKVPLQK------------------MGI NSVFDAGQADLSDLFE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MKTPQKISEARHKVFLNVTEFGCEVAPEAEVQPEVLK--------- -----------KNPDRKFFKADRPFVFAIRDRKNVY-------FVGHF---VKP------ --------------------------------------------------