>AgCASPL2 --------------------------------MNNKDRFLITHNVEKLVNYTNYKQLSFE CIQQKMLSPTMVSRIEGIAQDEVTRHKKLFEKITKRG-------------PKAFDTLLAI CQQAFPTAYLILKP---------------------------------------------- -------NSNDNQMHSTHNPQRVRSVSCNVAPKVYSLRSPGDVDDGKNNNFASNALVEES KC----------------------ILQVYPDILPTTFSVKLSTRPAETHPK--------- ---------------------------VPAYPMKGR-------------NRGVAFIVNVI TFLKKV------------HPTRNGADIDGRNLISVFQQLGF---VVFYYEDITMGDLKEL LAQLKESEHL-SCD--CFAFYILS--HGDHRKGSDYIFLHDNSLLRVEDLLTEFNSVNCK RLVHKPKLFFIS--ICR----GVQSDLGAYR-----------LSTNTERDGMIDPGKPLP -----SNIATYCDMLVCYATVPGFAA--HRDT--NTGSW-FVESMCKIWSEHA------- HDTDVEILMKLVGEYASS----------YRTEHSALQTICTEQR-GFFKQLFLNPGYYEN PVEL--------------------- >AaCASPL2 --------------------------------MDQRDRHQIQHNMDQLIQHTNYGVLMAE CVGRQMMSEVMKAIIEDRYPDEASRHKKLFEKITKRG-------------PHAFDILVSI CQRNFPTAYKLLKN---------------------------------------GNVSTVG SSSR---NSSQFEFNSTYHPNRVRSISA--GDYSGSELLRQRLANLSIGSPSYSEEDDAK NNNDTVEETTDKGGKRR-------LQEFGEKV-RSLYKVELSARPQSHRI---------- ---------------------------LEAYEMRRR-------------NRGVVFIVNVI TYINET------------HPTRNGAEADKYNLVSLFQQLGF---TVFYYEDLTSDEFNNL IKELKQSSYL-STE--CFVFYILA--HGNHTKGRDKIYLNDNSVLYVEDVLALFNNANCP KLIRRPKLFFFS--ICR----GDNPDYGTLR-----------LAEHTERDGMINLKKDPP -----TNMPTYADMLICFSTVPGYAA--HRDK--QYGSW-FVESMCKVWAQHA------- HDTDVEQLMKLVGKDSST---------YRTEHHNALQTLGSEQR-GFFNVLYLNPGYYED ------------------------- >CpCASPL2 --------------------------------MNQLERHRILRNMDQLIQNTNYEVLKKE CYLRRMLSEVMIAVIEDRYRDEASKHKKLFEKITKRG-------------PTAFQTLLEI CQGNFPAAYKLLKG---------------------------------------GPVVGFN QNQNLNVGGQHETFNSTFHPNRRRAVSANFGESSQLAVQQQRLERLSIGSRSISAEDEDA KNNNQEIETTD--GKMR-------LVEYLEPV-QDLLKVKLTTRPQRPRL---------- ---------------------------LEVYPMTST-------------RRGVIFIVNII KYKNNT------------HPTRNGAEADRDNLLSLFRQLGF---TVFYYEDLTNGDFQLL VKELKNSPHL-SAE--CFAFYILA--HGNHNKGWDKIYLNDNSILFVHDILKLFNNENCP KLIGRPKLFFFS--ICR----GDRADFGQYR-----------SDANTERDGMINRNKEPP -----TNMPTYADMYICFSTVPGFSA--HRDT--SLGSW-LVESMCKVWAEHA------- HDTDVEQLMKLVGKEMAR----------YRTENLGMQTLACEQY-GFYDLLYLNPGYSVE ------------------------- >DmDronc -----------------------MQPPELEIGMPKRHREHIRKNLNILVEWTNYERLAME CVQQGILTVQMLRNTQDLNGKPFNMDEKDVRVEQHRR-----------LLLKITQRGPTA YNLLINALRNINCL---------------------------------------DAAVLLE SVDESDSRPPFISLNERRTSRKSADIVDTPSPEASEGPCVSKLRNEPLGA---------- ------------------------LTPYVGVVDGPEVKKSKKIHGGDSAI---------- ---------------------------LGTYKMQSR-----------F-NRGVLLMVNIM DYPDQ-------------NRRRIGAEKDSKSLIHLFQELNF---TIFPYGNVNQDQFFKL LTMVTSSSYVQNTE--CFVMVLMT--HGNSVEGKEKVEFCDGSVVDMQKIKDHFQTAKCP YLVNKPKVLMFP--FCR----GDEYDLGHPKNQGNLMEPVYTAQEEKWPDTQTEGIPSPS -----TNVPSLADTLVCYANTPGYVT--HRDL--DTGSW-YIQKFCQVMADHA------- HDTDLEDILKKTSEAVGN-----------KRTKKGSMQTGAYDNLGFNKKLYFNPGFFNE ------------------------- >DmDredd -------------------------------------------MSASAIYRPFPKVKHFC IFPIAMAGSNLLIHLDTIDQNDLIYVERDMNFAQKVGLCFLLYGDDHSDATYILQKLLAM TRSDFPQSDLLIKFAKSRPETWRRHLVEALCIIGARKVLRRLGFCWQELRMHYLPHIAGI TLHVHPLLKSLYRMCEELSLVQSGRLLLDVREKVESQQAGDPLRFYDPAYLEIFLLDWLT RRSIKLGDINAAGSDVQLLVGH--LKSNGLQAQANLLKDTIISNAPEPDAAGTAAMAVKQ EIESDNQQSYCSTQ-------------IDALKLTRE-------------NAGIALIINQQ KFHRNKFLSPDP------LRRRDGTDVDKERLIEVFSSMGY---NVEAYDNVDHMGIIER IRSACDRSLV--RD--SLVVFILS--HGFE----EAVYASNSIAMKITDIEDLLCSYD-- TLYYKPKLLIIQ--ACQ----EKLVH--------------------KKKPNELFRIDVTT -----VSPDQHIDMLRAMSTVNGYAA--LRHT--QTGSW-FIGSLCDAIDRRS------- ASEHIADILTIVTNEVSK-----------KRGSNDESMVPNVKS-TFRQHVYFPPRL--- ------------------------- >AgCASPS13 ----------------------------------------------------MLINVLKF QQSMPFSVVVVQIVIHTKRWATFLQYLSIIGWQHIKM-------------TENANILYSK PLKTHKEVYFRIKQ---------------------------------------IIGMKQS NTRNNTYNNHNTSITYEKVTINQQFVAPPLSKHNRTPLFRALTMKMGISASSNQANKEEE TSEDEDN-----------------MFRSNESLDSNRYQSNSRIASDNAE----------- ----------------------------HSYTVTDKLPKMKPLQPTLLPKDAYVIVFHND EFDNS-------------ACNRPGSAKDMERIQQVLQHYRC--DKLDINENKPEEYVQQK MTEISQKDFT-PYS--CLIVFIMS--HGSVN---DTILASDGKWFYFQEDIVDKCTSNR- TLDGKPKLFVLQ--ACR----GNDRI-----------------------------VADAR -----PPRSDKVDVIIFQSTYQGYVS--LRDI--EEGSF-FMQSFLRLLHEKN------- -QQSIININTLLNREFKE---------------KKIAQVPTMTV-TLRRDLIFGELLR-- ------------------------- >AgCASPS9 ------------------------------------------------------------ ---------------------------------------------------MHVDAITKN CRQNDTS----------------------------------------------------- ------------------------------------------------------------ ------------------------VGYYTQPV-KS------------------------- ----------------------------GTYDLS---------------KNAYVLVFHHD QFKNP-------------KNNREGSANDMKQIKEFCQHYRC--DRLDINENKTKAEVTRK MGEISRKDFT-KNS--CLIVFIMS--HGSAN---DTIMAKDGQFYSFQDDVVEYCTSNR- TLNDKPKLFVLQ--ACR----GDATM-----------------------------VADAT -----PSMSYKGDIIIFQSSYQGAVS--FRDT--ESGSF-FMQAFLRLAHEHN------- -SESIVKINPLLNQEFTN--KNMPDGSTWFDLDNGRTQISGRNT-SLRMTF--------- ------------------------- >AgCASPS12 ------------------------------------------------------------ --------------------------------------------------MHVARTQPVK S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GTYDLS---------------KNAYVLVFHHD QFKNP-------------KNNREGSANDMKQIKEFCQHYRC--DRLDINENKTKAEVTRK MGEISRKDFT-KNS--CLIVFIMS--HGSAN---DTIMAKDGQFYSFQDDVVEYCTSNR- TLNDKPKLFVLQ--ACR----GDATM-----------------------------VADAT -----FSMSYKGDIIIFQSSYQGAVS--FRDT--ESGSF-FMQAFLRLAHEHN------- -SESIVKINPLLNQEFTN--KNMPGGSTWFDLDNGRMQISGRNT-SLRMTF--------- ------------------------- >DmDamm ------------------------------------------------------------ ------------------------------------M-------------YLPERTEHQK IERLYDS----------------------------------------------------- ------------------------------------------------------------ ------------------------NRVNAEPG---------------------------- ----------------------------QGLDLNEK-----------L-KPPAVYILNHE QFPQDS------------QLNRKGSSNDVNALRKTFESLKC---RVEVISNPALPDVKNK VKEWSAKRFT-QDA--GFVLFILS--HGDRK---EKILACDHREYHLDDDV-LFPLFRNP TLSGKPKILIVQ--ACK----GPLRADAKKM----------------------------- -----NNEP----YIKCYSCSEGYLS--YRNE--NHGSV-FIQTLCEAMDQYG------- LTRDFQSIFKHVKAEVER-----------RSTMTGSKQVPSEESHNFDKPFYFGNYAKNT ------------------------- >DmDream MGWWSKKSETDRSQPSQELVAQDPRTRVQTTSAATETTNTAVQNSTITDNNKQTVTFLTT RQTVTHTQRALITETTTRRTPSQAELEALFAKIKMGGEGPIGSTTTTTTTTSSRSRPPSL NGVSFRSTQPFKATASNAGKRSSTLVKTEQTTVTQKNGRTVTQHLETHRVDLKGSRPKAT WASFASTANSSTSSYVSPYRQKPSMAITCTSPNIKTPKTTSSTSSSSASSITSPPKPSSS VSSISSIFKSAPKQVDKPLSSTATPKPFISLGSSGGTKPKVTAVAQSQDAQGTISTSLG- ---------------------------ISKSSLTKN-----------KLKPARVYIFNHE RFDNK-------------NEFRKGSAQDVKVLRATFEQLKC---KVEVITDATLVTIKKT VRMLQTKDFE-DKS--ALVLVILS--HGTRH---DQIAAKDD-DYSLDDDVVFPILRNR- TLKDKPKLIFVQ--ACK----GDCQLGGFMT------------------------DAAQP -----NGSPN--EILKCYSTYEGFVS--FRT---EDGTP-FIQTLCEALNRSG------- KTSDIDTIMMNVRQVVKM--------------QSKDRQIPSVTS-TLTSKYVFGDYI--- ------------------------- >AaCASPS15 ----------------------------------------------------MSNKSSKT VTTLSHKQSTRSVTTSMTVSKSQTTSSGFVNSYGSPA-------------VADRAFVPGS SSKTYEPVYEKTRQ---------------------------------------LSRNTNT GSHTPKYQVPTQSATQSKDSNTAGGMFYSFQLTVDKKRSTSLENDVPALTVPNLGLTIAA AA----------------------PKIVTQDA-QPSNARSNTPVSPGPVTLS-------- ---------------------------LEKYDLR---------------KPAYVLIFHNI -FKNDK------------KFHRKGSEHDLKLIKEFVKGYNM--KIADICEDFSVTKVKKK MNKVSLKNFG-SYS--SLMIVIMS--HGGLN---DQIQASNG-FYHLDTTIVEPTLMNE- TLKGKPKLFFVQ--ACK----GDAVM-----------------------------EADAT -----QTATNKFDILKCFSTYEGTLS--FRDT--TEGTT-FIQTLFKLIEQNS------- -DKEIIDIMRLMRNIFCI---------------NKIAQAPTETS-TLTKKFYFNDLKK-- ------------------------- >AaCASPS16 ----------------------------------------------------MSNKSSKT VTTLSHKQSTRSVITTMTVSKLQTTSSGFVNSYGSPA-------------VADRAFVPGS SSKTYEPVYEKTRQ---------------------------------------LSTITNT RSNTPKYQEPTKSASPSMVSKTAGNLFNSFGTADDKKRYTSLEINIPPKYVPSSSWKSVT TTPTR-------------------SPNIVARDAQSSNARSNTPASPGPATVS-------- ---------------------------LEKYDLR---------------KPAYVLIFHNI -FKNNK------------QLHRKGSELDLKLIKEFVKGYNM--KIADICEDFSVTKVKKK MNEVTLKNFG-SYS--SLMIVIMS--HGGLN---DHIQTSNG-FYHLDTTIVEPTLMNE- TLKGKPKLFFVQ--ACK----GDAVM-----------------------------EADAT -----RTATNKFDILKCFSTYEGTLS--FRYT--TEGTT-FIQTLFKLIEQNS------- -DKEIIDIMRLMRNIFCV---------------NKIAQAPTETS-TLTKKFYFNDLKK-- ------------------------- >AaCASPS17 ------------------------------------------------------------ --------------------------------------------------MLYERLKPKS SATQSTSSDEL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KYDLT---------------KPAAVVIIHNL -FKNNP------------KRIRTGSQHDYKLLKDFFNELNA--EVIHDCQDLKVIEVKTT MEKVKKMDFG-AYS--CLIIVIMS--HGDIQ---NQICALDG-NYNLDDDIVQPATANK- SLKRKPKIFIVQ--ACK----GPNLI-----------------------------EADCN -----NTVPSPSDILICFSTYEGTPA--FRNV--DEGTY-FIQILIKMLKEKP------- -EKSIMDIMPLMRREFES---------------KRIHQVPAETT-TLTKLFFFHDLKKKP KKIPRRRNSIFYAVLRILFPRSMRL >AaCASPS21 ----------------------------------------------------MVRWSSVG SCTENKEESCSACQTQTTSSELVISQTPKLAEELAIA-------------GRISDLAPPS TTKTYEPVYDQTWR---------------------------------------------- LSASSSRNAPKYQISPTSLALGKAALRTTDDKKRSTTLNNYVPAKDVPSSSWKSAFAALT RSPKKVTQD---------------AQPTYPRTSTPAYLWIRPTSSTTQTTSSD------- ---------------------------ELKYDLT---------------KPAGVVIFHHL -FENDP------------ERIRRGSQHDHKLVIDFFNELNA--KVIYSHQDPKVRKVKTT MENVRKMDFG-AYS--CLIIVIMS--HGDIK---NQICALDG-KYNLDDDIVDPTRANK- SLRGRPKIFIVQ--ACK----GQNLI-----------------------------EADCN -----KTVPSPSDILICFSTYEGTPA--FRIV--DEGTY-FIQTLIKMLREMP------- -EMSIVEIMPLIRSEFRS---------------KGIRQVPTDMS-TLTKSFFFRDLKKRP HVSPTLVK----------------- >CpCASPS27 ------------------------------------------------------------ ----------------------------------MQM-------------LTDLSKLKEA HEAANVA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------YNLRD--------------GPCYVLVIHNR SFKSP-------------MSYRAGSEKDLNFVKDFCKTYRT--NSLDICENYSLLRLEDK MKKISIKDFN-RYS--SLLVIIMS--HGDTD---DRIYAYDG-LFDLEPDIVDPIVKNC- TLKEKPILFFIQ--ACR----GNNIM----------------------------DSDAAR -----IVQKNKANIIKCYSTYEGTIS--FRDS--ERGTY-FIQILLSLIKENE------- -DKDLSEIMDLIRRCFYR---------------ANIQQVPTSVS-TLTKKFFFRDLKY-- ------------------------- >CpCASPS28 -------------------------------MYNKGTKSTFSSSSQQYSSFRSATATSSS TTSRTVTSGGVLSSTVNSNSSSSTQHQSAFRRSSATA-------------ICNSPTAITQ NERPYNSVRGPLGQ---------------------------------------SYSGSVT GAAIGALGGYGSNRLERSTSSINRPLALPSSTSVTT------------------------ ------------------------GRPPLSPL-PQKTTWDAKPYPGSSFSSS-------- ---------------------------VERYNLRD--------------QKGYVLIFHHK HFKNA-------------KAIREGSEKDLQLLKHVFTRYRV--KKPDICENYTVLRIKDK MRK--KKDFS-KYS--CLLVIVMS--HGETK---DRIQAYDN-LYNFEQEVVERVLTNT- TLKDKPKLFFIQ--ACK----GSATM-----------------------------QHDAT -----SVATNKNDMLKCYSTYEGTVS--LRDP--RLGTY-FIQTLFTLIDEQG------- -DKDVADLMILTRRRFKD---------------DKVPQAPTDTS-TLTKKFYFRDLK--- ------------------------- >AgCASPL1 --------------------------------MQSIFLNSNYNFSNQIIGVASVIFLLYG QRNPQYALQILTVAGRAPEGEETNFLVDWMNHVPQAE----SWENELLEALTIMEQNLLL LQAGFDDAELRAKY---------------------------------------FPQTAEI ALHVHPMLKGLYHFCERLSDENAQKLVIQLQQSTTFAPLRHECMEIILLQLLINGNIELG LKQSGVESNVLLLTAACKAAELYDESDFLKSI-ASHYNRNVSQPNREQSDAT----AKHI PKVDDSPNSHARSNIPLPSVVQPVTSSLESYTFDPA-------------RAGTVLLINQF TFYRETNPELVELVPSRPLKDRKGTEVDKSALERLFNDFGY---DLLVEENITHHQILQA VQHAVQRTQP-IHC--SLVVCLLS--HGQEG----KVFGANSIPVEVRAIQQLMASE--- RLTGKPKLLIVQ--ACQ----GADLQSAVPV-----------------PIYEHDGLEGSE -----KTASVFMDFLVAWSTVPGFAS--IRHI--EKGSW-FIQELCAKLRQLY------- RSEHIMDILTAVINDVAS-----------KRGYGNECMVPIVQS-TLSKKLYFHRLE--- ------------------------- >CpCASPL1 -------------------------MSTTLSVEDLDFIECELSFDDKV----SLLFILYG QRNPRYLSQIITIACRSPE-EETHYLFDWKNHAAGPE-----WSSELLEALLIIQANLCL VKCGLDDDELRERF---------------------------------------LPHVIEL TSFVHPVLKGLYLLCEKMDDGLAGKVIDYLKKTHSVGVLNSRFFELVLLELISEDFVKLG SKSAGEECDLLLLVACFKSLDLYDLAEFCKRI-SDSFNKELTNKQNQSDNVQGSSNFKQI PKIEDQQQLD-----------------PDRYYILKQ-------------HAGIILIINQF KFHRDQNPELQDLLPLRPLNDRRGTEVDKLAILNIFTAFGY---XPLVVENIPHAEIPNA GRSPPPSKRRKVNPLFPLVVCLLSPWSGRAK---STASLNSI-PVNVKSIERAMAAEKXP ---GKPKLLFVQ--ACQ----GPEILPSRPG-------------------LEHDGPFIGK -----DGVPVFVEPFW-WALVHGKPGFAIRCDTFEKGGRGFIQELCVKLREKL------- ---HQRTFLTAVINXVSG-----------KRGLRQXCMVPIIYS-TLRKKLFFEPLK--- ------------------------- >AaCASPL1 -------------------------MSISIQLEDLDFIEEELHFDDKV----AVLFLLYG HRNPKYVLQLLTVAIRAPD-ARTQFLSEWANLVAKGEVSASRWQSELLEALAIVQANLCL LKCGFDDEELRAQF---------------------------------------LPHVPEL ATHVHPVLKGLWMLCEKMDKATCGRLENYLMQNYALTVTDSEFLEMVMLDMIGQGVIKLG SKEDGQVSDLSNLIAAFKALELEGLKDFCKNI-ESNFNRDLQSGENQSDNAK-STLVAEV KRQSVDNSDH-----------------LEKYVISWK-------------NAGLILIVNQF QFFRDSNPELADLIPSEPLKNRRGTEVDKMAILNLFTNLGY---EPIVVENIPHLEIMNQ VEQAVDRVEP-HHC--SLVICLLS--HGQEG----KVYGSNSIPVSVKAIERKMAAR--- KLTGKPKLLFVQ--ACQ----GSGLQTAVDV-----------------APRLEHDGPSSE -----TTASVFVDFLVAWSTVPGFAS--IRHI--EKGSW-FIQELCSKIRQLY------- ERDHLMDILTAVINDVSA-----------KRGYENECMVPIIYT-TLRKKLYFEALKVK- ------------------------- >CpCASPS22 ------------------------------------------------------------ --------------------------------MRSVT-------------LTQSKPIGAA TVTMFSS----------------------------------------------------- ------------------------------------------------------------ ------------------------IYTPVEPQ-SS------------------------- ----------------------------GSYSMESR-------------LRGKVLIFNQR EFSNG-------------YSTRIGTDRDVERLLKVLPRLGYAREHIEVFENLKASGIEKV ALKLQQDAQLHLCD--SLVVFFLT--HGEKN---DKLVAKDE-TFHLYEFIEKFKPAVMP AMAGKPKLFFVQ--ACR----GHKLKRGKQL--------------QNWVSETASYEESPP -----DSFPEFSDFLIAMSAQHGHLS--FRN---EQGSW-FIQELCNAFETFN------P HYDSILDILTTTNCAVSK------RTRNVDGRPDNRKQIANFYS-TLTKKLYFKPFQY-- ------------------------- >CpCASPS23 ------------------------------------------------------------ ----------------------MIAIRTLSTRSSPQN-------------ARFVNSVVKL YGTVMFST---------------------------------------------------- ------------------------------------------------------------ ------------------------IRTSVDPS---------------------------- ---------------------------SKRYSMESR-------------LRGKVLIFNQR EFTNG-------------YSPRVGTEKDVERLLQTLPLLGYAREHIKVFENQDASDIEAV AGKLKTDAELNQCD--SLVVFFLT--HGEQN---DRLVARDE-TFHLYEFIEHFTPAALP AMAGKPKLFVVQ--ACR----GGRLDRGVQL--------------QSLVSGLASTLDNRI -----FSYPEFADFLIAMSSHHGHVS--FRN---AQGSW-YIQELCNVIESFD------P DDESILDILTATNSAVSR------RVSNVDGRRNNKKQISSFYS-TLTKKLYFMPRPLQD ------------------------- >AaCASPS20 ------------------------------------------------------------ ----------MDVAGSVGSGKKFDRVDAKGTSNQSDS-------------ESEDAKPVKK TTDGIPKRKGSIY----------------------------------------------- ------------------------------------------------------------ ------------------------LDTPNGPN---------------------------- ---------------------------TKVYSMNGV-------------KRGKVLIFNQV TFEDTS------------YDERCGTHKDVERLFHVLPRLGFLKEDIHVYEDYSYGEIQRA AMKLELDEELHQAD--CLMVFILT--HGEAN---DKLMAQND-SYNLYEFLEHFTPTALK SMAGKPKLFIVQ--ACR----GRKLDRGVQLRA---------KLIQADCAKDVVDSQSVV -----YTYPEFADLLLVMSSHHGHYS--FRN---ETGSW-LIQEFCNVIEECD-----EL ATTSIYDLLTETNRAVSM------RISNADGDKDKKKQIPSFYS-TLTKKLYFSPRK--- ------------------------- >CpCASPS20 ------------------------------------------------------------ -MNPGEPPADNPGHGKPLYSDFFKFDFVDAKPSASRR-------------NSDVQDASGF AVRNNSTIAAAASS---------------------------------------------- ------------------------------------------------------------ ------------------------RSLPVEPVPLPVPTRKGSTYLDTPTSPM-------- ---------------------------SRVYAMNGA-------------KRGKVLIFNQV EFDVVD------------YPERFGTHSDVERLYMTLPRLGFQREDISVFQDFSVGEIRRE AMRLQVDKDLEEAD--CLVVILLT--HGEEG---DYLMAQDD-RYHLYEFIENFTPTALN SMAGKPKLFIVQ--ACR----GKKLDRGVNLRAK--------LIQADSVPKDVVDSQSGV -----FSYPEFADLMIVMSSHHGHYS--FRN---ETGSW-LIQELCNVIDSCD------L EQDSIYDILTETNKRVAG------RSSNADGEFHNKKQIPSFYS-TLTRQLYFRPAQ--- ------------------------- >CpCASPS24 ------------------------------------------------------------ --------------------------------RETTD-------------AARFTDSATS PSGSKEA----------------------------------------------------- ------------------------------------------------------------ ------------------------LPTPNGPD-CA------------------------- -----------------------------VYAMNGS-------------RRGKVLIFNHF KFDEREKDEKS-------LEPRHGTDEDVKTLRETLPKLGFLKDDIKEFKDRTKKEIWEA TEELRNDADLKNSD--CLMVVILT--HGEQN---DILWAKDT-TYCLYDLIEQFKPSLLQ SMAGKPKIFVVE--APR----GDKIDYGVNLTAI--------NNGSSGTQEDSFCPKIET -----FKYPEHADLMILMSSHHGHTSNLYANP--KQGSW-FIQQLCNVIEQCD------P KTDSIIDMIIATNSAVSK-----------EKGEDNVKQISSFYS-TFTKQMFFGMEH--- ------------------------- >CpCASPS25 ------------------------------------------------------------ -----------------------------MDPSQIPD-------------IESVVSGLNR KRNDDKTL---------------------------------------------------- ------------------------------------------------------------ ------------------------LPTPNEAL---------------------------- ---------------------------STKYTMNGT-------------RRGKVIIFNHF TFYDKNGKTR--------FKPRDGSDNDVKKLQDTLPKLGFCLEDIKVFPDCNEEQMFEV FTKLDSDNDLESSD--CLIVVILT--HGGAN---DKLAACDR-DYRLYDLIDKCNPVNLP SMAGKPKIFIVQ--ACR----GENKDSGVKLHAA--------SNGSSSTQVDFISSQADN -----FTHPEHADLLVLMSSHYGCKA--YR----KHGSW-LIQELGNVIERLE------A KPCSIFDILIQTNNAVAK-----------RETREGLKQIPSFYS-TFIKQLYFDIKN--- ------------------------- >CpCASPS26 ------------------------------------------------------------ -----------------------------MNPTQHPE-------------IVTADLKRKR SDDILP------------------------------------------------------ ------------------------------------------------------------ ------------------------TSNGLTSI---------------------------- -----------------------------AYAMNRT-------------NRGKVLIFNQV ECAG--------------ESPRRGSDEDVKKLLETLPKLGFLPSDIKVCTNYTKDQIYEK VSKLDDENELNDAD--CLMVVILT--HGTHG---DALMASDQ-LYHLYDLIDQFTPLALP SMAGKPKIFIVQ--ACR----GGREDAGANLYVEN-------NNGSNYTQVDDLGSQAHT -----FTYPEYADLLIMMASHYDHVS--YRST--VRGSW-FIQHLCSVIEKCD------R KLNSIFDIVIKTNNAVSK------------QGQYGPQQISSFYS-TLTKQLFFDPRKK-- ------------------------- >DmDecay ------------------------------------------------------------ ------------------------MDDTDFSLFGQKN-------------KHKKDKADAT KIAHTPTSELDL------------------------------------------------ ------------------------------------------------------------ ------------------------KRIIISRPTNE------------------------- ----------------------------DTYENCA--------------RAGIALILNHK DVKG--------------QKQRVGTERDRDDMEATLQGFGF---DVRTFDDLTFSEINDT LKEVAREDHS-QND--CFVLAVMS--HGTEG----KVYAKDM-SYPVERLWNPFLGDNCK TLKNKPKLFFIQ--ACR----GANLEKAVEFSSFAV------MTRELVPEPAA-AVQPIT -----YAIPSTADILVFYSTFDKFFS--FRNV--DDGSW-FIQSLCRVLDQAAANEAATP EGVELLRLLTAVNRKVAY---EYQSNT-KNEALNQMKEMPNFMS-TLTKTFQLRVKPKT- ------------------------- >DmDcp1 ------------------------------------------------------------ -MTDECVTRNYGVGIRSPNGSENRGSFIMADNTDAKG-----------CTPESLVVGGAT AASPLPANKFV------------------------------------------------- ------------------------------------------------------------ ------------------------ARMPVERY---------------------------- ---------------------------ASEYNMSHK-------------HRGVALIFNHE FFDIPS------------LKSRTGTNVDAQELKKAFENLGF---AVSVHKDCKLRDILKH VGKAAELDHT-DND--CLAVAILS--HGEHG----YLYAKDT-QYKLDNIWHYFTATFCP SLAGKPKLFFIQ--ACQ----GDRLDGGITL---------------EKGVTETDGESSTS -----YKIPIHADFLFSYSTIPGYFS--WRNI--NNGSW-YMQSLIRELNANG------- KKYDLLTLLTFVNQRVAL---DFESNVPATPMMDRQKQIPCLTS-MLTRILRFGDKPNGN KAG---------------------- >DmIce ------------------------------------------------------------ MDATNNGESADQVGIRVGNPEQPNDHTDALGSVGSGG-------------AGSSGLVAGS SHPYGSGAIGQLAN---------------------------------------------- ------------------------------------------------------------ -----------------------GYSSPSSSYRKNVAKMVTDRH---------------- ---------------------------AAEYNMRHK-------------NRGMALIFNHE HFEVPT------------LKSRAGTNVDCENLTRVLKQLDF---EVTVYKDCRYKDILRT IEYAASQNHS-DSD--CILVAILS--HGEMG----YIYAKDT-QYKLDNIWSFFTANHCP SLAGKPKLFFIQ--ACQ----GDRLDGGVTM---------------QRSQTETDGDSSMS -----YKIPVHADFLIAYSTVPGFYS--WRNT--TRGSW-FMQSLCAELAANG------- KRLDILTLLTFVCQRVAV---DFESCTPDTPEMHQQKQIPCITT-MLTRILRFSDKQLAP AGRV--------------------- >AgCASPS7 ------------------------------------------------------------ --------MSMPDVVDIRNEINKEHVRESLDRNGDEQ-----------QLVQDVNDALGT RKGHDPTNHLVR------------------------------------------------ ------------------------------------------------------------ ------------------------ARMPVERYACD------------------------- ------------------------------YNMNHK-------------RRGLALIFNHE NFDVPQ------------LRSRAGTNVDCENLTASLKGLDF---EVHVFKDLKLRDLQKE VERVSQMDHS-DAD--CLLVTILS--HGELG----YLYAKDC-QYKLDTIWTYFTANHCP SLAGKPKLFFIQ--ACQ----GDQLDGGVVL-------------EAKDRTETDSSSSMLT -----FKIPMYADFMIAYSTIPGFYS--WRNT--QKGSW-FIQSLCHELNQNG------- RKYDLMVLLTFVTQRVAY---DFESNTPDIPMMHQQKQIPCTTS-MLTRLVYFNQKK--- ------------------------- >AaCASPS7 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MPVDRY---------------------------- ---------------------------ASEYNMNHP-------------KRGFALIFNHE HFEIPQ------------LKARTGTNVDCENLAATLKYLDF---DVRVYKDLKLREVQKE VEKVAMMDHS-EHD--CVSITILS--HGELG----YLYAKDC-QYKLDIIWSYFTANRCP TLAGKPKVFFIQ--ACQ----GDQLDAGVTL----------------AERTETDSAGSMS -----YKIPAHADFLIAYSTIPGFYS--WRNT--QKGSW-FMQSLCQELTQHG------- KKYDLLTLLTFVAQRVAY---DFESNTPDIPMMHQQKQIPCVTT-MLTRLLRFTEK---- ------------------------- >CpCASPS7 ------------------------------------------------------------ ------------MSDTGLIEDQQPIQADVQDSNKTST-------------TKFTDVADAL GHGNGLDHYGNRLK---------------------------------------------- ------------------------------------------------------------ ------------------------ARMPVDRY-AS------------------------- -----------------------------DYNMNHP-------------KRGLALIFNHE HFEIPQ------------LKSRAGTNVDCENLASTLKHLDF---DVRVYKDMKLRDMQKE VEKVAKMDHS-DND--CILITILS--HGELG----YLYAKDC-QYKLDIIWSYFTANHCP TLAGKPKLFFIQ--ACQ----GDQLDAGVTL----------------SDRTETDSAGSMS -----YKIPAHADFLIAYSTIPGFYS--WRNT--QKGSW-FMQSLCQELNQHG------- KKYDILTLLTFVAQRVAY---DFESNTPDIPMMHQQKQIPCVTT-MLTRLLRFTDK---- ------------------------- >AgCASPS8 ------------------------------------------------------------ -------------------QPLTKAFSAMFSRKQEDS-------------SDTRGMPHGS PIASGSQTANGIIR---------------------------------------------- ------------------------------------------------------------ ------------------------PAYVIERY-AA------------------------- -----------------------------YYPMNHK-------------RRGMALIFSHN KYNVRNVS----------LPVREGSAIDCKRLKETLELFRF---DVKVYPDFKLEEIKSV IGKVSSMDHS-DSD--CFLVAILT--HGEDG---GIVYAYDQ-PYELSLIWSFFTADNCP SLAGRPKIFVVQ--ACR----GNQLDHGVKV----------------------QKDGVAR -----YSIPTHADFLFAYATIPGFMA--FRNT--TEGSW-FINELCKELQENG------- HRYDINTLLTFVTQKVAY---DHESVS-NMPEYNMRKQTPCVVS-MLTRLLLFNVV---- ------------------------- >CpCASPS29 ------------------------------------------------------------ ----------------------MSTLSLTMERAKKAQ-------------FWRRGSSFSP SRLPVN------------------------------------------------------ ------------------------------------------------------------ ------------------------PAYVIDRT---------------------------- ---------------------------GAYYPMNHK-------------RRGKALIFTHE TFAKSTK-----------LASRKGAKVDSKALGKSLKRLGF---DVDIYSDKGKEEINKI TEKASRQDHS-NAD--CLLVAILT--HGDDG---DSLCAQDG-SYQFTSVWSQFTEERCP SLAGKPKIFIVQ--ACR----GQELDPGVAT---------------------VEQDGIAR -----YIGSAEANFLFAFATAPGFMS--FRNV--ESGSW-FIQELCVELNENG------- ERYDLLTLFTFVTQRVAH---LHESNAPDTLEYHQKKQIPCIVS-KLTRLLLISGRG--- ------------------------- >AaCASPS8 ------------------------------------------------------------ ----------------------------------MKK-------------IMFGRKEVNS PQQMIPTVA--------------------------------------------------- ------------------------------------------------------------ ------------------------PAYTIERY---------------------------- ---------------------------SAYYPMNHK-------------HRGKAIIFAHS VFAVKNVN----------LPNRDGSDVDCEMLVESLKRLHF---DVTLYKDYRLKDILLV IEKVSLMDHS-NSD--CLLVAVLS--HGDEG---EVIYAHDC-PYQISSIWTQFTGDRCR TLVGKPKIFIIQ--ACR----GNDLDSGVKV----------------------EKDGVAR -----YSIPTNADFLFAFATIPGYMS--FRNT--KNGSW-FIRELCNELNENG------- QRYDMLTLLTFVVQKVAY---GYESYAPVHPDHHMKKQTPCVVS-MLTRLLLFNNV---- ------------------------- >CpCASPS8 ------------------------------------------------------------ --------------------------------MKKIM-------------FGRKESGPSL NSPAVPP----------------------------------------------------- ------------------------------------------------------------ ------------------------PAYTIDRY---------------------------- ---------------------------SSYYPMNHK-------------NRGKAIIFTHA VFAVPNVK----------LPAREGSEVDCKALTESLERLGF---DVDLYRDKRLKDILHI TEKVSLMDHS-SSD--CLLVAVLT--HGDEG---EIIYAHDC-PYQISSVWTQFTGDRCP TLIGKPKIFIIQ--ACR----GNELDQGVKV----------------------EKDGVAR -----YSIPTHADFLFAFATIPGFMS--FRNT--RNGSW-FIREFCNELNENG------- QRYDLLTLLTFVVQKVAY---GYESIAPNTPEYHLKKQTPCIVS-MLTRLLLFNYV---- ------------------------- >AgCASPS14 ------------------------------------------------------------ ----------------------------------------------------MDATIINN NHSSLEA----------------------------------------------------- ------------------------------------------------------------ ------------------------MDSTLQLT---------------------------- ---------------------------LHSYNMAHP-------------KRGIAVVINN- ------------------NRDRKGSEKDVKALQAVLSHLQF---DVRLLSDKTTVEIRHA LKEVSKEDHT-NND--CLAIIAMA--HGYN----DRIKFDDD-YLHIDELWTNFVGNKCP SLIGKPKLVFIQ--SCR----GGKLDYGASI---------------ATADARPGLEEPVD -----VKIPMYADLLVMYSSFEHHSS--IRCR--NEGSW-FIQSFCQVLGANI------- AKTELQALLCHVSYLVSI-----RSDQTIDPEGKVVKQIPMVTS-MLTKAFYFVPK---- ------------------------- >AgCASPS1 ------------------------------------------------------------ -----------------------------------------------------MDSILEF E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LKSYDTTHP-------------NRGIAVVIND- ------------------SERREGSEKDVQDVVATLEGLKF---NVRTFQDNTKKEIKKA LYKVAREDHN-END--CLVIVAMA--HGKK----DHITLKKE-KLRIDKLWASFVGNKCP SLIGKPKLVFIQ--TCR----GDNVDFGVAS---------------HETDSTPCSVDPAP -----GIIPMYADLLVMYSSYDRHIS--VRCK--DKGSW-FIQSLCQVLRANI------- AGKELISLLTQVSYIVSC-------QTSITSDGETVKQIPSINS-MLTKAFYFVPKQTQQ IS----------------------- >AgCASPS2 ------------------------------------------------------------ -----------------------------------------------------MDSLLEL E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LQSYKTNHP-------------NRGIAVVIND- ------------------SENRDGWEKDLEAVETVLQRLKC---DVRTFCDKTKHEIRDA LRNVSKEDHT-KSD--CLVIVAMA--HGNN----DKITLRRG-EMHIDELWTDFVGNGCP SLIGKPKLVFIQ--SCR----GNKHDYLVGG---------------AAVDAVPSPEKPIC -----VEIPMYADLLVMYSSYDQYVS--YRDK--EEGSW-FIQSLCQVLGANI------- AGKDLLTLLTHVSYLVSVRSFLMESEVNMVKRTGVLKQIPSINS-MLTKAFYFVDK---- ------------------------- >CpCASPS31 ------------------------------------------------------------ -----------------------------MDKGSTNE-------------VDVLGLMEYI PNSSMPSA---------------------------------------------------- ------------------------------------------------------------ ------------------------NITPKSRPTVE------------------------- ----------------------------ENYNTNHK-------------YRGLALIFCNM EFQKELK-----------MPKRVATEKDRDDICDALENLSF---NVKVNNDLNKEEVQKT LKEWSQEKHHIDND--CLVVVIMT--YGGNG----FVYAKDG-KYEVDTLWKNFVGNACP SLIGKPKIFFIQGWVLE----GKQYNDVKDS-------------SLKLKDCMASEHQKPP -----FFIPTWADLLIM---DNGPNT--WEDD--LTGSC-LIQSLCKELKEYD------- ASCELLTLLTKVIRRTIY-------GYTLSGSNNKPVQMPCMIS-MLTKSFYFIKKDNIL DD----------------------- >AgCASPS5 ------------------------------------------------------------ -------------------------MDDLPPEPTPDN-------------EFYDGNIPSI TQTDQIASR--------------------------------------------------- ------------------------------------------------------------ ------------------------QRSQNARALQE------------------------- ----------------------------EEYDTNHR-------------RRGMAIILNHE NFEL--------------MSKREGTNRDRDAATAVLTSMQF---DVRVYNDLGRDELFCV LLALASEDHS-DCD--CLLVMLMT--HGDD----DVLYAYDG-PYSVDKLWESFMGNACT TLLGKPKLFFVQ--ACR----GSTFDKGVKL---------------GCRDLDSDHFSSHK -----YVIPTTADLLVMYSSYKGHVS--WRSP--RGGSW-FIQALCVELETNW------- KHMELLQLLTGVSRRVAY---DYQSNEPSKGRMDAMKQMPSIVS-MLTKLVYFPLKLGS- ------------------------- >AgCASPS3 ------------------------------------------------------------ ----------------------MDTAPDEIDVKPFSS-------------PSPTEPPARA HRGSVVS----------------------------------------------------- ------------------------------------------------------------ ------------------------SPHALAAV-QE------------------------- ----------------------------ENYDTSHR-------------NRGTALIFNHV NFES--------------NAKREGSNKDRDEIKKELLQLGF---DARVFNDLKKQELLAK LDEVAKEDHT-ESD--CFVLVMMT--HGQDG----SLYAADK-QYQIAELWEPFVGDACK TLIGKPKLFFVQ--ACR----GTKFDKGVKL-----------TKIATDTVDALSSSSQRT -----CVIPTMADVLVMYSAFDGHYS--WRNP--THGSW-FIQSLSIELNQHA------- HRKELLQLLTSVSRRVAY---LYESNVPGNEQMDGKKQMPCVVS-MLTKALYFPRK---- ------------------------- >AgCASPS4 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MFNRI---------------------------- ---------------------------DECYDTSNA-------------RRGIALIINQV IFSS--------------MAVRVGSSKDRTDISTVLQRIGF---EVRVMDDPNRKQLLSA LKQLAGEDHS-HSD--CLVVVVMT--HGKEN---NLLYASDK-SYEANQLWEPFIGDACP SLIGKPKLFFVQ--ACR----GKKLDEGVIQ-----------ATISIDSVDTQSSPGSMR -----YVIPAMADLLVMYSTYDGHYS--WRNP--SKGSW-FIQSLCAELGASA------- HCKELLHILTAVSRRVAC------------------KEADALYGVHVNQAALFEAKKIGE TP----------------------- >AgCASPS6 ------------------------------------------------------------ --------------------MNTSTLSTAFDEVDNNT--------------RVLSLVASV PEIISSS----------------------------------------------------- ------------------------------------------------------------ ------------------------VIHELEPVDDA------------------------- -----------------------------HYNMSHN-------------RRGVAAVFNHR KFLH--------------ASERKGTDADCDNIRQVLIYLQF---EVRVYDDLTRKEIKQV LDDLAEEDHK-NSD--CLLVVIMT--HGDD----DVLHAKDG-TFNVDRLWENFIGDSCP SLLGKPKLFFIQ--ACR----GSSFDTGVHFSQCMTQVAKTVVPYAMRELPQPSIVPGCP KSSIQYAIPSMADLLVMYSTYKGHYS--WRNP--STGSW-FIRALCDELREHG------- NSKELLQLLTSVSRRVAY---EFQSNVPNNSQIDCQKQMPCIVS-MLTRRIYFSKK---- ------------------------- >CpCASPS30 ------------------------------------------------------------ ---------------------------------------------------MSKQVVTEN PEYSSSA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------NLYDTTND-------------YRGLALVFNHE NFET--------------EKKRDGTNEDRDNLKDLLSSLKF---DVHIYDDLNKKEVLKT LKIWSEEKYS-DCD--CLVVVVMT--HGDPH----NLYAKDS-CYPVESLWVNFIGNRCP SLIGKPKMFFIQ--ACR----GKALDQGVVF------------DPERQNDKKDCKTYEGS -----NSSPPMADLLVMYSTYEGHCS--WRNP--KDGGV-FIQTLCSELKANG------- NKRELLTLLTGVSRRTAY---EFQSYVPDDEKYNAKKQMPCLVS-TLTKSFYFTDKTTSK KFELK-------------------- >AaCASPS18 ------------------------------------------------------------ -------------------------------MDTADE-------------LDVLGFGNKT NESSTSN----------------------------------------------------- ------------------------------------------------------------ ------------------------ENRPLSRPTCD------------------------- ----------------------------EYYDMSNK-------------RRGIALVFCHM NFAV--------------MAKRNGTDKDRDDICSTLSGLDF---DVRVFNDLRRKELLRT LKNVSREDHS-END--CLVVVVMS--HGDQG----VLYASDK-KYYVDSLWEKFTGNACP SLIGKPKLFFVQ--ASRERQPGKKGEGGREE-----------ESQASVDVVDSPNDSSAL -----YFIPTMADFLVMYSTYDGYYS--GKDP--LQRSC-LIQSLCMELDENG------- RERDLLALLTGVSRRALY---TCESSVPHNEKDNALKPIPCVVS-MLTKTFFFTKKT--- ------------------------- >AaCASPS19 ------------------------------------------------------------ -------------------------------MDTTDE-------------LDVLGFGSRT NESSKSI----------------------------------------------------- ------------------------------------------------------------ ------------------------KEALVSRAALD------------------------- ----------------------------EYYDTTNK-------------RRGIALVFCHM NFSV--------------MAKRNGADKDRDDICNTLYGLDF---DVRVFDDLSRKEVLDR LKDVSREDHS-DND--CLVVVMMS--HGEQG----VLYARDN-KYNVDSLWKNFVGNACP SLIGKPKMFFIQ--ACR----GEQFDEGVAY------------AAKSPKDMVDSRQEQVL -----YSIPAMADLLVMYSTYDGYYS--WRNP--RQGSW-FIQSLCTELDENG------- RVRDLLTLLTGVSRRTAY---EFQSFVPHNAKMDAMKQIPCIVS-MLTKTFYFTKKTRSR VVTDID------------------- >CpCASPS19 ------------------------------------------------------------ --------------------------MDTDGSKSADE-------------LDVLGFGSKS NSSRPAA----------------------------------------------------- ------------------------------------------------------------ ------------------------KEKPVSRPTLE------------------------- ----------------------------EYYDTTNG-------------RRGQALVFSHM NFTA--------------MAKRNGTDKDRDDICTALYELDF---NVHVYEDLSRKEVLET LKKWSLEDHS-DSD--CLVVVVMS--HGEEG----VLYARDS-KYNVDALWKNFVGNACP SLIGKPKMFFIQ--ACR----GEEFDEGVTL------------KMDGPKDMVDSKKEQVA -----YSIPAMADLLVMYSTYDGHYS--WRNP--KQGSW-FIQSMCREFKENG------- RVRDLLTLLTGVARRTAY---EYQSFVPNNEKMDAMKQMPCLVS-MLTKTFYFTKKTKSK VVTAIE-------------------